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Current Issue of PLoSBiology

Current Issue | PLOS Genetics
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Table of Contents

June 2025

Cover

Gradient of Hpo1, an intracellular pattern regulator in Tetrahymena
Issue Image

A super-resolution microscopy image of the apical region of the ciliate Tetrahymena thermophila stained with the anti-centrin (green) that marks the basal bodies. The cell expresses Hpo1-3xHA (red), a protein that regulates the positions of cortical organelles on the circumferential (left-right) cell axis. Note that Hpo1 forms a bilateral gradient with a high point on the cell’s right (viewer’s left) side. See Lee et al.

Image Credit: Chinkyu Lee

Research Articles

Left-right cortical interactions drive intracellular pattern formation in the ciliate Tetrahymena

Chinkyu Lee, Ewa Joachimiak, Wolfgang Maier, Yu-Yang Jiang, Mireya Parra, Karl F. Lechtreck, Eric S. Cole, Jacek Gaertig

PLOS Genetics: published June 2, 2025 | https://doi.org/10.1371/journal.pgen.1011735

JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium

Nawrah Khader, Anna Dorogin, Oksana Shynlova, Jennifer A. Mitchell

PLOS Genetics: published June 2, 2025 | https://doi.org/10.1371/journal.pgen.1011261

ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas

Thea P. Paasch, Morten T. Jarlstad Olesen, Juan L. García-Rodríguez, Adrienne M. Assmus, Robert A. Fenton, Jørgen Kjems, Henrik Hager, Lasse S. Kristensen

PLOS Genetics: published June 2, 2025 | https://doi.org/10.1371/journal.pgen.1011726

Ubinuclein 2 is essential for mouse development and functions in X chromosome inactivation

Asun Monfort, Giulio Di Minin, Sarah Sting, Charles Etienne Dumeau, Peter Scambler, Anton Wutz

PLOS Genetics: published June 2, 2025 | https://doi.org/10.1371/journal.pgen.1011711

HarmGR13 mediates myo-inositol taste perception in Helicoverpa armigera larvae

Yu-Sheng Tan, Bao-Tong Mo, Guo-Cheng Li, Yu-Ruo Guo, Jian-Zhen Zhang, Chen-Zhu Wang

PLOS Genetics: published June 3, 2025 | https://doi.org/10.1371/journal.pgen.1011744

Fitness consequences of sex chromosome aneuploidy in Drosophila melanogaster

Elizabeth R. Makovec, Caitlin C. Kestell, Kayla K. Janke, Ethan J. Carter, Aaron P. Ragsdale, Nathaniel P. Sharp

PLOS Genetics: published June 3, 2025 | https://doi.org/10.1371/journal.pgen.1011703

Sodium azide mutagenesis induces a unique pattern of mutations

Chaochih Liu, Giulia Frascarelli, Adrian O. Stec, Shane Heinen, Li Lei, Skylar R. Wyant, Erik Legg, Monika Spiller, Gary J. Muehlbauer, Kevin P. Smith, Justin C. Fay, Peter L. Morrell

PLOS Genetics: published June 3, 2025 | https://doi.org/10.1371/journal.pgen.1011634

Environmental data provide marginal benefit for predicting climate adaptation

Forrest Li, Daniel J. Gates, Edward S. Buckler, Matthew B. Hufford, Garrett M. Janzen, Rubén Rellán-Álvarez, Fausto Rodríguez-Zapata, J. Alberto Romero Navarro, Ruairidh J. H. Sawers, Samantha J. Snodgrass, Kai Sonder, Martha C. Willcox, Sarah J. Hearne, Jeffrey Ross-Ibarra, Daniel E. Runcie

PLOS Genetics: published June 9, 2025 | https://doi.org/10.1371/journal.pgen.1011714

Methylobacterium extorquens PA1 utilizes multiple strategies to maintain formaldehyde homeostasis during methylotrophic growth

Zachary T. Hying, Anya M. Rushmer, Chin Yi Loh, Eric L. Bruger, Jannell V. Bazurto

PLOS Genetics: published June 9, 2025 | https://doi.org/10.1371/journal.pgen.1011736

Role of the SAF-A/HNRNPU SAP domain in X chromosome inactivation, nuclear dynamics, transcription, splicing, and cell proliferation

Judith A. Sharp, Emily Sparago, Rachael Thomas, Kaitlyn Alimenti, Wei Wang, Michael D. Blower

PLOS Genetics: published June 10, 2025 | https://doi.org/10.1371/journal.pgen.1011719

A mathematical framework for the quantitative analysis of genetic buffering

Jim Karagiannis

PLOS Genetics: published June 10, 2025 | https://doi.org/10.1371/journal.pgen.1011730

Root remodeling mechanisms and salt tolerance trade-offs: The roles of HKT1, TMAC2, and TIP2;2 in Arabidopsis

Nouf O. Alshareef, Vanessa J. Melino, Noha Saber, Annamaria De Rosa, Elodie Rey, Jian You Wang, Salim AlBabili, Caitlin Byrt, Mark A. Tester, Magdalena M. Julkowska

PLOS Genetics: published June 11, 2025 | https://doi.org/10.1371/journal.pgen.1011713

Titin-Truncating variants predispose to dilated cardiomyopathy in populations genetically similar to african and european reference populations

John DePaolo, Marc R. Bornstein, Renae Judy, Sarah Abramowitz, Shefali S. Verma, Michael G. Levin, Penn Medicine Biobank, Zoltan Arany, Scott M. Damrauer

PLOS Genetics: published June 13, 2025 | https://doi.org/10.1371/journal.pgen.1011727

Visualizing androgen signaling and assessing its interaction with canonical Wnt signaling pathways in prostate development, morphogenesis, and regeneration

Yao Mawulikplimi Adzavon, Dong-Hoon Lee, Alex Hiroto, Tae Ju Park, Gaeul Chu, Yunjeong Kim, Kristoffer Nikias, Cheong-Wun Kim, Dexter Hoi Long Leung, Chenmiao Liu, Hong Zeng, Zijie Sun

PLOS Genetics: published June 13, 2025 | https://doi.org/10.1371/journal.pgen.1011756

Loss of FIC-1-mediated AMPylation activates the UPRER and upregulates cytosolic HSP70 chaperones to suppress polyglutamine toxicity

Kate M. Van Pelt, Matthias C. Truttmann

PLOS Genetics: published June 13, 2025 | https://doi.org/10.1371/journal.pgen.1011723

An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan

Marc Tatar, Wenjing Zheng, Shweta Yadav, Rochele Yamamoto, Noelle Curtis-Joseph, Shengxi Li, Lin Wang, Andrey A. Parkhitko

PLOS Genetics: published June 16, 2025 | https://doi.org/10.1371/journal.pgen.1011640

Monkeyflower (Mimulus) uncovers the evolutionary basis of the eukaryote telomere sequence variation

Surbhi Kumawat, Askhan Shametov, Liia R. Valeeva, Yoonha Ju, Irene Martinez, Dhenugen Logeswaran, Hongfei Chen, Jenn M. Coughlan, Julian J.-L. Chen, Yao-Wu Yuan, James M. Sobel, Dal-Hoe Koo, Eugene V. Shakirov, Jae Young Choi

PLOS Genetics: published June 16, 2025 | https://doi.org/10.1371/journal.pgen.1011738

Cell cycle dependent methylation of Dam1 contributes to kinetochore integrity and faithful chromosome segregation

Prashant K. Mishra, Wei-Chun Au, John S. Choy, Pedro G. Castineira, Afsa Khawar, Chloé Tessier, Sudipto Das, Andresson Thorkell, Peter H. Thorpe, Elaine Yeh, Kerry S. Bloom, Munira A. Basrai

PLOS Genetics: published June 16, 2025 | https://doi.org/10.1371/journal.pgen.1011760

Basal association of a transcription factor favors early gene expression

Sandrine Pinheiro, Mariona Nadal-Ribelles, Carme Solé, Vincent Vincenzetti, Yves Dusserre, Francesc Posas, Serge Pelet

PLOS Genetics: published June 16, 2025 | https://doi.org/10.1371/journal.pgen.1011710

The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development

Anja Strohdiek, Anna M. Köhler, Rebekka Harting, Helena Stupperich, Jennifer Gerke, Emmanouil Bastakis, Piotr Neumann, Yasar L. Ahmed, Ralf Ficner, Gerhard H. Braus

PLOS Genetics: published June 16, 2025 | https://doi.org/10.1371/journal.pgen.1011687

The PavMYB.C2-UFGT module contributes to fruit coloration via modulating anthocyanin biosynthesis in sweet cherry

Yangang Pei, Wanjia Tang, Yidi Huang, Hongfen Li, Xiaowei Liu, Hongxu Chen, Runmei He, Wenyi Niu, Quanyan Du, Yizhe Chu, Heng Deng, Mingchun Liu, Ronggao Gong

PLOS Genetics: published June 17, 2025 | https://doi.org/10.1371/journal.pgen.1011761

Distinct domains of ENHANCER OF PINOID hold information for its polarization required for auxin-mediated cotyledon and flower development in Arabidopsis

Michaela S. Matthes, Nicole Yun, Miriam Luichtl, Ulrich Büschges, Birgit S. Fiesselmann, Benjamin Strickland, Marietta S. Lehnardt, Kay Schneitz, Klaus Michel, Ramon A. Torres Ruiz

PLOS Genetics: published June 23, 2025 | https://doi.org/10.1371/journal.pgen.1011217

A genetic modifier links integrin α5 to the phenotypic variation in fibronectin 1a mutant zebrafish

Samuel J. Capon, Anastasia Maroufidou, McKenna Feltes, Yanli Xu, Darpan Kaur Matharoo, Dörthe Jülich, Scott A. Holley, Steven A. Farber, Didier Y. R. Stainier

PLOS Genetics: published June 23, 2025 | https://doi.org/10.1371/journal.pgen.1011747

Inheritance bias of deletion-harbouring mtDNA in yeast: The role of copy number and intracellular selection

Nataliia D. Kashko, Georgii Muravyov, Iuliia Karavaeva, Elena S. Glagoleva, Maria D. Logacheva, Sofya K. Garushyants, Dmitry A. Knorre

PLOS Genetics: published June 24, 2025 | https://doi.org/10.1371/journal.pgen.1011737

Genetic disease risks of under-represented founder populations in New York City

Mariko Isshiki, Anthony J. Griffen, Paul Meissner, Paulette Spencer, Michael D. Cabana, Susan D. Klugman, Mirtha Colón, Zoya Maksumova, Shakira Suglia, Carmen R. Isasi, John M. Greally, Srilakshmi M. Raj

PLOS Genetics: published June 24, 2025 | https://doi.org/10.1371/journal.pgen.1011755

Defining the high-translational readthrough stop codon context

Daniela Smoljanow, Dennis Lebeda, Julia Hofhuis, Sven Thoms

PLOS Genetics: published June 25, 2025 | https://doi.org/10.1371/journal.pgen.1011753

Transposable element expression is associated with sex chromosome number in humans

Jordan Teoli, Miriam Merenciano, Marie Fablet, Anamaria Necsulea, Daniel Siqueira-de-Oliveira, Alessandro Brandulas-Cammarata, Audrey Labalme, Hervé Lejeune, Jean-François Lemaitre, François Gueyffier, Damien Sanlaville, Claire Bardel, Cristina Vieira, Gabriel AB Marais, Ingrid Plotton

PLOS Genetics: published June 26, 2025 | https://doi.org/10.1371/journal.pgen.1011668

Performance of two low-threshold population replacement gene drives in cage populations of the yellow fever mosquito, Aedes aegypti

Zachary J. Speth, David G. Rehard, Patricia J. Norton, Alexander W.E. Franz

PLOS Genetics: published June 26, 2025 | https://doi.org/10.1371/journal.pgen.1011757

The transcription factors Tfeb and Tfe3 are required for survival and embryonic development of pancreas and liver in zebrafish

Alberto Rissone, Martina La Spina, Erica Bresciani, Zulfeqhar A. Syed, Christian A. Combs, Martha Kirby, Abdel Elkahloun, Vicky Chen, Raman Sood, Shawn M. Burgess, Rosa Puertollano

PLOS Genetics: published June 27, 2025 | https://doi.org/10.1371/journal.pgen.1011754

Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans

Abhishek Mishra, Norma V. Solis, Siobhan M. Dietz, Audra L. Crouch, Scott G. Filler, Matthew Z. Anderson

PLOS Genetics: published June 27, 2025 | https://doi.org/10.1371/journal.pgen.1011650

Structural basis for higher-order DNA binding by a bacterial transcriptional regulator

Frederik Oskar Graversgaard Henriksen, Lan Bich Van, Ditlev Egeskov Brodersen, RagnhildBager Skjerning

PLOS Genetics: published June 27, 2025 | https://doi.org/10.1371/journal.pgen.1011749

Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function

Saskia Hüsken, Annika Röder, Johannes Ptok, Anne E. Meyer, Mats Georg, Yannick Schwarz, Christian Roos, Kerstin Mätz-Rensing, Michael C. Hutter, Doreen M. Floss, Allan E. Rettie, Marco Girhard, Helmut Hanenberg, Constanze Wiek

PLOS Genetics: published June 27, 2025 | https://doi.org/10.1371/journal.pgen.1011750

Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis

Saeko Takada, Bonnie J. Bolkan, MaryJane O’Connor, Michael Goldberg, Michael B. O’Connor

PLOS Genetics: published June 27, 2025 | https://doi.org/10.1371/journal.pgen.1011469

STRIPAK complex defects result in pseudosexual reproduction in Cryptococcus neoformans

Patricia P. Peterson, Sarah Croog, Yeseul Choi, Sheng Sun, Joseph Heitman

PLOS Genetics: published June 30, 2025 | https://doi.org/10.1371/journal.pgen.1011774

Flipping the switch on some of the slowest mutating genomes: Direct measurements of plant mitochondrial and plastid mutation rates in msh1 mutants

Amanda K. Broz, Mychaela M. Hodous, Yi Zou, Patricia C. Vail, Zhiqiang Wu, Daniel B. Sloan

PLOS Genetics: published June 30, 2025 | https://doi.org/10.1371/journal.pgen.1011764