Recombination plasticity in response to temperature variation in reptiles

Laura González-Rodelas, Cristina Marín-García, Clara Romero, Gala Pujol, Laia Marín-Gual, Lukáš Kratochvíl, Aurora Ruiz-Herrera

PLOS Genetics: published August 4, 2025 | https://doi.org/10.1371/journal.pgen.1011772

Beyond recombination: Exploring the impact of meiotic frequency on genome-wide genetic diversity

Louis Ollivier, Brian Charlesworth, Fanny Pouyet

PLOS Genetics: published August 4, 2025 | https://doi.org/10.1371/journal.pgen.1011798

The association between parental BMI and offspring adiposity: A genetically informed analysis of trios

Liam Wright, Gemma Shireby, Tim T. Morris, Neil M. Davies, David Bann

PLOS Genetics: published August 5, 2025 | https://doi.org/10.1371/journal.pgen.1011775

Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction

W. James Gauderman, Yubo Fu, Bryan Queme, Eric Kawaguchi, Yinqiao Wang, John Morrison, Hermann Brenner, Andrew Chan, Stephen B. Gruber, Temitope Keku, Li Li, Victor Moreno, Andrew J. Pellatt, Ulrike Peters, N. Jewel Samadder, Stephanie L. Schmit, Cornelia M. Ulrich, Caroline Um, Anna Wu, Juan Pablo Lewinger, David A. Drew, Huaiyu Mi

PLOS Genetics: published August 5, 2025 | https://doi.org/10.1371/journal.pgen.1011543

SRS2 is required for MUS81-dependent CO formation in zmm mutants

Valentine Petiot, Floriane Chéron, Charles I. White, Olivier Da Ines

PLOS Genetics: published August 7, 2025 | https://doi.org/10.1371/journal.pgen.1011637

Natural SEL1L variants rescue a model of NGLY1 deficiency and modify ERAD function and proteasome sensitivity

Travis K. Tu’ifua, Clement Y. Chow

PLOS Genetics: published August 7, 2025 | https://doi.org/10.1371/journal.pgen.1011823

Gene dosage and protein valency impact phase separation and fungal cell fate

Collin Ganser, Peiling He, Corey Frazer, Damian J. Krysan, Richard J. Bennett

PLOS Genetics: published August 8, 2025 | https://doi.org/10.1371/journal.pgen.1011810

An l-fucose-responsive transcription factor cross-regulates the expression of a diverse array of carbohydrate-active enzymes in Trichoderma reesei

Qinqin Zhao, Liwei Gao, Nuo Xu, Xiuting Zhang, Yuqi Qin, Yinbo Qu, Guodong Liu

PLOS Genetics: published August 11, 2025 | https://doi.org/10.1371/journal.pgen.1011815

Threshold-dependent negative autoregulation of PIF4 gene expression optimizes growth and fitness in Arabidopsis

Sreya Das, Vikas Garhwal, Krishanu Mondal, Dipjyoti Das, Sreeramaiah N. Gangappa

PLOS Genetics: published August 11, 2025 | https://doi.org/10.1371/journal.pgen.1011758

Polymerization and flanking domains of the bactofilin BacA collectively regulate stalk formation in Asticcacaulis biprosthecum

Maxime Jacq, Paul D. Caccamo, Yves V. Brun

PLOS Genetics: published August 13, 2025 | https://doi.org/10.1371/journal.pgen.1011542

Role of Pcdh15 in the development of intrinsic polarity of inner ear hair cells

Raman Kaushik, Shivangi Pandey, Anubhav Prakash, Fenil Ganatra, Takaya Abe, Hiroshi Kiyonari, Raj K. Ladher

PLOS Genetics: published August 13, 2025 | https://doi.org/10.1371/journal.pgen.1011825

Understanding the alcohol harm paradox: A multivariable mendelian randomization approach

Gemma Sawyer, Hannah Sallis, Marcus Munafò, Liam Mahedy, Jasmine Khouja

PLOS Genetics: published August 14, 2025 | https://doi.org/10.1371/journal.pgen.1011824

High-fat diet impairs intermediate-term memory by autophagic-lysosomal dysfunction in Drosophila

Tong Yue, Minrui Jiang, Kotomi Onuki, Motoyuki Itoh, Ayako Tonoki

PLOS Genetics: published August 18, 2025 | https://doi.org/10.1371/journal.pgen.1011818

The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice

Soomin Cho, Emilia Servián-Morilla, Victoria Navarro, Beatriz Rodriguez-Gonzalez, Youxi Yuan, Raquel Cano, Arjun A. Rambhiya, Radbod Darabi, Robert S. Haltiwanger, Carmen Paradas, Hamed Jafar-Nejad

PLOS Genetics: published August 18, 2025 | https://doi.org/10.1371/journal.pgen.1011806

Dynamics of recombination, X inactivation and centromere proteins during stick insect spermatogenesis

Zoé Dumas, William Toubiana, Marie Delattre, Tanja Schwander

PLOS Genetics: published August 18, 2025 | https://doi.org/10.1371/journal.pgen.1011827

RAB23 loss-of-function mutation causes context-dependent ciliopathy in Carpenter syndrome

Wan Ying Leong, Wai Lam Tung, Andrew O. M. Wilkie, Catherine Hong Huan Hor

PLOS Genetics: published August 18, 2025 | https://doi.org/10.1371/journal.pgen.1011611

The highly dynamic pangenome of basal chordates is enriched in defence and immunity genes and is inherited following the Mendelian law

Umberto Rosani, Marco Gerdol, Mart Krupovic

PLOS Genetics: published August 18, 2025 | https://doi.org/10.1371/journal.pgen.1011833

Two pairs of CACNA1I (Ca_V3.3) variants with opposite effects on channel function cause neurodevelopmental disorders of varying severity

Yousra El Ghaleb, Monica L. Fernández-Quintero, Marta Campiglio, Petronel Tuluc, Ann-Sophie Höing, Fanny Kortüm, Mahdi M. Motazacker, Iris E. Jansen, Mariet W. Elting, Astrid S. Plomp, Anna-Lena M. Fischer, Victoria M. Siu, Kerstin Kutsche, Bernhard E. Flucher

PLOS Genetics: published August 18, 2025 | https://doi.org/10.1371/journal.pgen.1011828

Mutations mark cell lineages and sectors in flowers of a woody angiosperm

Yilun Ji, Xiaonan Chen, Xiaohui Zhang, Wenjing Wang, Lan Xue, Yifan Zhong, Dacheng Tian, Sihai Yang, Long Wang, Milton Brian Traw, Ju Huang

PLOS Genetics: published August 18, 2025 | https://doi.org/10.1371/journal.pgen.1011829

Transcriptomic landscape and chromatin accessibility uncover pivotal regulators driving programmed larval-larval molting in the domesticated silkworm

Yun Wang, Xin Yang, Junfeng Hong, Lingyi Li, Xia Ling, Liang Qiao, Ze Zhang, Wei Sun

PLOS Genetics: published August 19, 2025 | https://doi.org/10.1371/journal.pgen.1011837

Deciphering the RNA-based regulation mechanism of the phage-encoded AbiF system in Clostridioides difficile

Marion Saunier, Adeline Humbert, Victor Kreis, Johann Peltier, Arianna Tisba, Sylvie Auxilien, Marion Blum, Isabelle Caldelari, Jean-François Lucier, Joe Ueda, Daniel Gautheret, Claire Toffano-Nioche, Jessica Andreani, Louis-Charles Fortier, Olga Soutourina

PLOS Genetics: published August 19, 2025 | https://doi.org/10.1371/journal.pgen.1011831

Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development

Valeria Silva, Robert Scott, Paulina Guajardo, Haojiang Luan, Ruben Herzog, Benjamin H. White, John Ewer

PLOS Genetics: published August 20, 2025 | https://doi.org/10.1371/journal.pgen.1011672

Rapid emergence of non-autonomous elements may stop P-element invasions in the absence of a piRNA-based host defence

Matthew Beaumont, Divya Selvaraju, Riccardo Pianezza, Robert Kofler

PLOS Genetics: published August 20, 2025 | https://doi.org/10.1371/journal.pgen.1011649

Detecting latent interaction effects when analyzing binary traits

Ziang Zhang, Jerald F. Lawless, Andrew D. Paterson, Lei Sun

PLOS Genetics: published August 22, 2025 | https://doi.org/10.1371/journal.pgen.1011822

Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter

Molly Hydorn, Sathya Narayanan Nagarajan, Elizabeth Fones, Caroline S. Harwood, Jonathan Dworkin

PLOS Genetics: published August 22, 2025 | https://doi.org/10.1371/journal.pgen.1011691

ETS transcription factor pointed controls germline survival in Drosophila

Alicia E. Rosales-Nieves, Miriam Marín-Menguiano, Lourdes López-Onieva, Juan Garrido-Maraver, Acaimo González-Reyes

PLOS Genetics: published August 25, 2025 | https://doi.org/10.1371/journal.pgen.1011809

Circulating proteins associated with histological subtypes of lung cancer from genetic and population-based perspectives

Zhangyan Lyu, Guojin Si, Mengbo Xing, Wenxuan Li, Ximin Gao, Meng Wang, Fengju Song, Kexin Chen

PLOS Genetics: published August 25, 2025 | https://doi.org/10.1371/journal.pgen.1011821

Tissue-specific consequences of tag fusions on protein expression in transgenic mice

Gillian C. A. Taylor, Lewis Macdonald, Natalia A. Szulc, Evelina Gudauskaite, Brianda Hernandez Moran, Jennifer M. Brisbane, Molly Donald, Ella Taylor, Dejin Zheng, Bin Gu, Pleasantine Mill, Patricia L. Yeyati, Wojciech Pokrzywa, Claudia Ribeiro de Almeida, Andrew J. Wood

PLOS Genetics: published August 25, 2025 | https://doi.org/10.1371/journal.pgen.1011830

Idiosyncratic evolvability among single-point ribosomal mutants towards multi-aminoglycoside resistance

Laura Sánchez-Maroto, Guillem A. Devin, Pablo Gella, Alejandro Couce

PLOS Genetics: published August 25, 2025 | https://doi.org/10.1371/journal.pgen.1011832

The actin module of endocytic internalization in Aspergillus nidulans: A critical role of the WISH/DIP/SPIN90 family protein Dip1

Marisa Delgado, Mario Pinar, Paula Polonio, Sergio Fandiño, Eduardo A. Espeso, Miguel A. Peñalva

PLOS Genetics: published August 26, 2025 | https://doi.org/10.1371/journal.pgen.1011619

A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects

Gist H. Farr III, Whitaker Reid, Eva H. Hasegawa, Azzam Azzam, Isabelle Young, Mona L. Li, Aaron K. Olson, David R. Beier, Lisa Maves

PLOS Genetics: published August 26, 2025 | https://doi.org/10.1371/journal.pgen.1011579

Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion

Joanne L. Thorvaldsen, Aimee M. Juan, Yemin Lan, Christopher Krapp, Marisa S. Bartolomei

PLOS Genetics: published August 29, 2025 | https://doi.org/10.1371/journal.pgen.1011834

On the role of the terminal oxidase cytochrome bd in hyper-resistance of Listeria monocytogenes to the macrodiolide antibiotic tartrolon B

Vitaliy B. Borisov, Elena Forte

PLOS Genetics: published August 26, 2025 | https://doi.org/10.1371/journal.pgen.1011803

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PLOS Genetics: published August 14, 2025 | https://doi.org/10.1371/journal.pgen.1011813