Epigenetic relay: Polycomb-directed DNA methylation in mammalian development

Teresa Urli, Maxim V. C. Greenberg

PLOS Genetics: published September 15, 2025 | https://doi.org/10.1371/journal.pgen.1011854

Deficiency of Kif15 impairing synaptic development leads to mood disorder in mice

Xiaomei He, Wei Zhang, Xu Chen, Zhangji Dong, Chengyuan Wei, Tao Wu, Dexia Kong, Roujia Kong, Ronghua Wu, Yan Liu, Mei Liu

PLOS Genetics: published September 2, 2025 | https://doi.org/10.1371/journal.pgen.1011839

Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women

Amonae Dabbs-Brown, Chang Liu, Qin Hui, Peter W.F. Wilson, Jin J. Zhou, Marta Gwinn, Yan V. Sun

PLOS Genetics: published September 2, 2025 | https://doi.org/10.1371/journal.pgen.1011470

The MIR157–SPL15 module regulates flowering and inflorescence development in Arabidopsis thaliana under short days and in Arabis alpina

Adrian Roggen, Alba Lloret, Yohanna Miotto, Kang Wang, Kerstin Luxa, Vidya Oruganti, Serena Della Pina, Annabel D. van Driel, Youbong Hyun, Bruno Huettel, George Coupland

PLOS Genetics: published September 2, 2025 | https://doi.org/10.1371/journal.pgen.1011799

Conservation and divergence of ciprofloxacin persister survival mechanisms between Pseudomonas aeruginosa and Escherichia coli

Gabrielle Leon, Mark P. Brynildsen

PLOS Genetics: published September 2, 2025 | https://doi.org/10.1371/journal.pgen.1011840

Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans

Lizeth I. Tamayo, Lin Tong, Tetiana Davydiuk, Donald Vander Griend, Syed Emdadul Haque, Tariqul Islam, Farzana Jasmine, Muhammad G. Kibriya, Joseph Graziano, Lin Chen, X. Chris Le, Habibul Ahsan, Mary V. Gamble, Brandon L. Pierce

PLOS Genetics: published September 2, 2025 | https://doi.org/10.1371/journal.pgen.1011826

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review

Shiying Liu, William S. Bush, Rufus O. Akinyemi, Goldie S. Byrd, Allison Mercedes Caban-Holt, Farid Rajabli, Christiane Reitz, Brian W. Kunkle, Giuseppe Tosto, Jeffery M. Vance, Margaret Pericak-Vance, Jonathan L. Haines, Scott M. Williams, Dana C. Crawford

PLOS Genetics: published September 4, 2025 | https://doi.org/10.1371/journal.pgen.1011701

Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinoma

Ken Furudate, Shuya Kasai, Tadashi Yoshizawa, Yuya Sasaki, Kohei Fujikura, Shintaro Goto, Ryohei Ito, Koki Takagi, Tomoyuki Tanaka, Hiroshi Kijima, Kosei Kubota, Ken Itoh, Wataru Kobayashi, Koichi Takahashi

PLOS Genetics: published September 4, 2025 | https://doi.org/10.1371/journal.pgen.1011791

Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish

Iván Olaya, Ilara N. Yilmaz, Naima Nour-Kasally, Ross E. Charboneau, Bruce W. Draper, Sean M. Burgess

PLOS Genetics: published September 5, 2025 | https://doi.org/10.1371/journal.pgen.1011656

A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli

Víctor M. Hernández-Rocamora, Alessandra M. Martorana, Aitana Belloso, Daniel Ballesteros, Marta Zaccaria, Amilcar J. Perez, Bogdan I. Iorga, David Abia, Joe Gray, Eefjan Breukink, Jie Xiao, Manuel Pazos, Alessandra Polissi, Waldemar Vollmer

PLOS Genetics: published September 5, 2025 | https://doi.org/10.1371/journal.pgen.1011626

Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase

Maria Disen Barbuti, Eivind Frøyland Skjennum, Viktor Hundtofte Mebus, Danae Morales Angeles, Matilde Hustad, Marita Torrissen Mårli, Dorte Frees, Morten Kjos

PLOS Genetics: published September 5, 2025 | https://doi.org/10.1371/journal.pgen.1011841

Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression

Jonah N. Cullen, Jakub Cieslak, Jessica L. Petersen, Rebecca R. Bellone, Carrie J. Finno, Ted S. Kalbfleisch, Kirstine Calloe, Stefano Capomaccio, Katia Cappelli, Stephen J. Coleman, Ottmar Distl, Sian A. Durward-Akhurst, Elena Giulotto, Natasha A. Hamilton, Emmeline W. Hill, Lisa M. Katz, Dan A. Klaerke, Gabriella Lindgren, David E. MacHugh, Mariusz Mackowski, James N. MacLeod, Julia Metzger, Barbara A. Murphy, Ludovic Orlando, Terje Raudsepp, Maurizio Silvestrelli, Eric Strand, Teruaki Tozaki, Dagmar S. Trachsel, Laura S. Valderrama Figueroa, Brandon D. Velie, Claire M. Wade, Bianca Waud, James R. Mickelson, Molly E. McCue

PLOS Genetics: published September 5, 2025 | https://doi.org/10.1371/journal.pgen.1011835

Topo IV is required to allow replisomes to converge and complete replication on the chromosome

Parisa D. Mokhtari, Tannos Seyedjavadi, Thulni A. Liyanaarachchi, Charmain T. Courcelle, Justin Courcelle

PLOS Genetics: published September 8, 2025 | https://doi.org/10.1371/journal.pgen.1011857

Distinct cellular and molecular mechanisms contribute to the specificity of the two Drosophila melanogaster chitin synthases in chitin deposition

Joan Bertran-Mas, Ettore De Giorgio, Nicolás Martín, Marta Llimargas

PLOS Genetics: published September 8, 2025 | https://doi.org/10.1371/journal.pgen.1011847

A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation

Manon Budzyk, Anthony Simon, Anne-Sophie Mace, Renata Basto

PLOS Genetics: published September 8, 2025 | https://doi.org/10.1371/journal.pgen.1011605

Diversity and spread of cytoplasmic incompatibility genes among maternally inherited symbionts

Julien Amoros, Marie Buysse, Anna Maria Floriano, Bouziane Moumen, Fabrice Vavre, Didier Bouchon, Olivier Duron

PLOS Genetics: published September 9, 2025 | https://doi.org/10.1371/journal.pgen.1011856

Clusters of deep intronic RbFox motifs embedded in large assembly of splicing regulators sequences regulate alternative splicing

Francesco Tomassoni-Ardori, Mary Ellen Palko, Melissa Galloux, Lino Tessarollo

PLOS Genetics: published September 9, 2025 | https://doi.org/10.1371/journal.pgen.1011855

Functional redundancy and formin-isoform independent localization of tropomyosin paralogs in Saccharomyces cerevisiae

Anubhav Dhar, V.T. Bagyashree, Sudipta Biswas, Jayanti Kumari, Amruta Sridhara, Subodh B. Jeevan, Shashank Shekhar, Saravanan Palani

PLOS Genetics: published September 9, 2025 | https://doi.org/10.1371/journal.pgen.1011859

The small GTPase Rho5—Yet another player in yeast glucose signaling

Franziska Schweitzer, Linnet Bischof, Stefan Walter, Silke Morris, Hans-Peter Schmitz, Jürgen J. Heinisch

PLOS Genetics: published September 9, 2025 | https://doi.org/10.1371/journal.pgen.1011858

Meiotic Sex Chromosome Inactivation: Conservation across the Drosophila genus

Camila C. Avelino, Carolina A. Mendonca, Gabriel Goldstein, Henry Bonilla Bruno, Antonio Bernardo Carvalho, Maria D. Vibranovski

PLOS Genetics: published September 11, 2025 | https://doi.org/10.1371/journal.pgen.1011511

Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP₇ in land plants

Ranjana Yadav, Guizhen Liu, Priyanshi Rana, Naga Jyothi Pullagurla, Danye Qiu, Henning J. Jessen, Debabrata Laha

PLOS Genetics: published September 11, 2025 | https://doi.org/10.1371/journal.pgen.1011838

Phylogenomic timetree-calibrated speciation clocks for Caenorhabditis nematodes reveal slow but disproportionate accumulation of post-zygotic reproductive isolation

Daniel D. Fusca, Maia N. Dall’Acqua, Santiago Sánchez-Ramírez, Asher D. Cutter

PLOS Genetics: published September 11, 2025 | https://doi.org/10.1371/journal.pgen.1011852

Genome-wide association study provides novel insight into the genetic architecture of severe obesity

Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E. Justice, Geetha Chittoor, Hung-Hsin Chen, Rashedeh Roshani, Alyssa Scartozzi, Rachel R. Dickerson, Roelof A. J. Smit, Michael H. Preuss, Nathalie Chami, Benjamin S. Hadad, Esteban J. Parra, Miguel Cruz, Qin Hui, Peter W. F. Wilson, Yan V. Sun, Xiaoyu Zhang, Gregorio V. Linchangco, Sharon L. R. Kardia, Jessica D. Faul, David R. Weir, Lawrence F. Bielak, Heather M. Highland, Kristin L. Young, Baiyu Qi, Yujie Wang, Myriam Fornage, Christopher Haiman, Iona Cheng, Ulrike Peters, Charles Kooperberg, Steven Buyske, Joseph B. McCormick, Susan P. Fisher-Hoch, Frida Lona-Durazo, Jesus Peralta, Jamie Gomez-Zamudio, Stephen S. Rich, Kendra R. Ferrier, Ethan M. Lange, Christopher R. Gignoux, Eimear E. Kenny, Genevieve L. Wojcik, Kelly Cho, Michael J. Gaziano, Luc Djousse, Shuwei Liu, Dhananjay Vaidya, Renée de Mutsert, Navya S. Josyula, Christopher R. Bauer, Wei Zhao, Ryan W. Walker, Jennifer A. Smith, Leslie A. Lange, Mariah C. Meyer, Ching-Ti Liu, Lisa R. Yanek, Miryoung Lee, Laura M. Raffield, Ruth J. F. Loos, Penny Gordon-Larsen, Jennifer E. Below, Kari E. North, Mariaelisa Graff

PLOS Genetics: published September 12, 2025 | https://doi.org/10.1371/journal.pgen.1011842

MIG-21 interacts with Wnt and Netrin signaling in gonad migration in C. elegans

Xin Li, Kacy Lynn Gordon

PLOS Genetics: published September 15, 2025 | https://doi.org/10.1371/journal.pgen.1011866

Dynamic phosphorylation of Hcm1 promotes fitness in chronic stress

Michelle M. Conti, Jillian P. Bail, Aurelia R. Reynolds, Linnea G. Budge, Mackenzie J. Flynn, Rui Li, Lihua Julie Zhu, Jennifer A. Benanti

PLOS Genetics: published September 15, 2025 | https://doi.org/10.1371/journal.pgen.1011874

Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase

Michael A. Trebino, Giordan Kitts, James R. J. Haycocks, Rachel Wheat, Issac Chaudry, Jin Hwan Park, Ivan Erill, David C. Grainger, Fitnat H. Yildiz

PLOS Genetics: published September 15, 2025 | https://doi.org/10.1371/journal.pgen.1011870

Integrative transcriptomic analysis of Korean high-grade serous ovarian cancer

Hyondeog Kim, Youngwook Kim, Juyeong Park, Dong-Min Shin, Ji Hyun Kim, Madhawa Gunathilake, So Young Kwon, Junyoung Shin, Chong Woo Yoo, Sang-Yoon Park, Myong Cheol Lim, Jeongseon Kim

PLOS Genetics: published September 15, 2025 | https://doi.org/10.1371/journal.pgen.1011660

Single-cell consequences of X-linked meiotic drive in stalk-eyed flies

Peter D. Price, Sylvie M. Parkus, Victoria J. Lloyd, Ben T. Alston, Sasha L. Bradshaw, Sadé Bates, Margaret A. Hughes, Steve Paterson, Terry Burke, Iulia Darolti, Andrew Pomiankowski, Alison E. Wright

PLOS Genetics: published September 18, 2025 | https://doi.org/10.1371/journal.pgen.1011816

Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons

Sara Cuvertino, Evgenii Martirosian, Kedar Bhosale, Peiwen Cheng, Terence Garner, Ian J. Donaldson, Adam Jackson, Adam Stevens, Andrew D. Sharrocks, Susan J. Kimber, Siddharth Banka

PLOS Genetics: published September 19, 2025 | https://doi.org/10.1371/journal.pgen.1011608

Zebrafish optic nerve injury results in systemic retinal ganglion cell dedifferentiation

Ashrifa Ali, Hannah Schriever, Dennis Kostka, Takaaki Kuwajima, Kristen M. Koenig, Jeffrey M. Gross

PLOS Genetics: published September 19, 2025 | https://doi.org/10.1371/journal.pgen.1011879

Genomic profiling and experimental validation of type VI secretion system-associated proteins in Klebsiella

Ning Zhu, Yuzhe Zhao, Wenjing Yi, Lili Jiang, Tingting Dong, Zhihan Peng, Shanshan Jia, Ruihong Wu, Xiaohan Guo, Arnab Pain, Lei Song, Qingtian Guan

PLOS Genetics: published September 19, 2025 | https://doi.org/10.1371/journal.pgen.1011878

Ripply3 overdosage induces mid-face shortening through Tbx1 downregulation in Down syndrome models

José Tomás Ahumada Saavedra, Claire Chevalier, Agnes Bloch Zupan, Yann Herault

PLOS Genetics: published September 22, 2025 | https://doi.org/10.1371/journal.pgen.1011873

The Drosophila mauritiana synaptonemal complex protein C(3)G repatterns the recombination landscape of Drosophila melanogaster

Stacie E. Hughes, Cynthia Staber, Grace McKown, Zulin Yu, Justin P. Blumenstiel, R. Scott Hawley

PLOS Genetics: published September 23, 2025 | https://doi.org/10.1371/journal.pgen.1011882

Naphthoquinone preferentially pairs with non-proton-pumping NADH dehydrogenase for respiratory electron transport

Snehal V. Khairnar, Anjali V. Patil, L. Karvannan, Amitesh Anand

PLOS Genetics: published September 24, 2025 | https://doi.org/10.1371/journal.pgen.1011877

FaTRAB1, a bZIP transcription factor, enhances anthocyanin biosynthesis in strawberry leaves via tissue-specific regulation

Min Yang, Chenghui Song, Yuanxiu Lin, Yunting Zhang, Mengyao Li, Qing Chen, Yong Zhang, Haoru Tang, Ya Luo

PLOS Genetics: published September 24, 2025 | https://doi.org/10.1371/journal.pgen.1011888

From paleness to albinism: Contribution of OCA2 exon 10 skipping to hypopigmentation

Elina Mercier, David-Alexandre Trégouët, Sébastien Campagne, Vincent Michaud, David J. Green, Shahram Mesdaghi, Orane Le Gallais, Orphée Jouannigot-Castano, Daniel J. Rigden, Catherine Estay-Ahumada, David Hicks, Panagiotis I. Sergouniotis, Benoit Arveiler, Sophie Javerzat

PLOS Genetics: published September 25, 2025 | https://doi.org/10.1371/journal.pgen.1011801

Individual lipid alterations at the origin of neuronal Ceramide Synthase defects

Anna B. Ziegler, Cedrik Wesselmann, Konstantin Beckschäfer, Anna-Lena Wulf, Neena Dhiman, Peter Soba, Christoph Thiele, Reinhard Bauer, Gaia Tavosanis

PLOS Genetics: published September 25, 2025 | https://doi.org/10.1371/journal.pgen.1011880

Conserved Calcineurin A splice variants regulate both constitutive and experience-dependent behaviors through tissue-specific signaling

Martina Rudgalvyte, Dominique A. Glauser

PLOS Genetics: published September 26, 2025 | https://doi.org/10.1371/journal.pgen.1011884

Single cell RNA-sequencing reveals no evidence for meiotic sex chromosome inactivation in the threespine stickleback fish

Daniel E. Shaw, Wynter D. Ross, Alexis V. Lambert, Michael A. White

PLOS Genetics: published September 29, 2025 | https://doi.org/10.1371/journal.pgen.1011875

Metabolic coupling of ROS generation and antioxidant synthesis by the GABA shunt pathway in myeloid-like blood progenitor cells of Drosophila

Manisha Goyal, Sakshi Tiwari, Jagriti Arora, Bruce Cooper, Ramaswamy Subramanian, Tina Mukherjee

PLOS Genetics: published September 29, 2025 | https://doi.org/10.1371/journal.pgen.1011602

Identifying genetic determinants of outer retinal function in mice using a large-scale gene-targeted screen

Janine M. Wotton, Mark P. Krebs, Riccardo Sangermano, Jessica K. Wong, Cynthia Smith, Amelia M. Willett, Douglas Howell, Abby Jones, Catherine Witmeyer, Jacob P. Lowy, Michael McFarland, Stephan A. Murray, Robert E. Braun, Patsy M. Nishina, Eric A. Pierce, Emily M. Place, Kinga M. Bujakowska, Neal S. Peachey, Jacqueline K. White

PLOS Genetics: published September 29, 2025 | https://doi.org/10.1371/journal.pgen.1011886

On the analysis of genetic association with long-read sequencing data

Gengming He, Stephen W. Scherer, Lisa J. Strug

PLOS Genetics: published September 29, 2025 | https://doi.org/10.1371/journal.pgen.1011887

Polycomb repressive complexes 1 and 2 independently and dynamically regulate euchromatin during cerebellar neurodevelopment

Aditya Parmar, Anjali Srinivasan, Lena Krockenberger, Abijith Augustine, Owin Gong, Addison C. Bullard, Riya Kalra, Leya Ledvin, Dylan Pilz, Jonathan Tawil, Challana E. Tea, Kelly C. Wang, Olivia Urso, Larissa M. Kaube, Ying Sun, Roman Sasik, Kyle J. Gaulton, Kathleen M. Fisch, Cole J. Ferguson

PLOS Genetics: published September 29, 2025 | https://doi.org/10.1371/journal.pgen.1011843

Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk

Jenna C. Carlson, Xinyi Zhang, Zeynep Erdogan-Yildirim, Terri H. Beaty, Azeez Butali, Carmen J. Buxó, Lord J.J. Gowans, Jacqueline T. Hecht, Ross E. Long, Lina Moreno, Jeffrey C. Murray, Ieda M. Orioli, Carmencita Padilla, George L. Wehby, Eleanor Feingold, Elizabeth J. Leslie-Clarkson, Seth M. Weinberg, Mary L. Marazita, John R. Shaffer

PLOS Genetics: published September 30, 2025 | https://doi.org/10.1371/journal.pgen.1011581

From individuals to ancestries: Towards attributing trait variation to haplotypes

Yaoling Yang, Daniel J. Lawson

PLOS Genetics: published September 30, 2025 | https://doi.org/10.1371/journal.pgen.1011883

Meta-evolutionary exome analysis identifies novel type 2 diabetes mellitus genes in the UK Biobank and all of us

Kevin Wilhelm, Jennifer Asmussen, Kwanghyuk Lee, Maryam Samieinasab, Emmanuel Asante, Marek Kimmel, Olivier Lichtarge

PLOS Genetics: published September 30, 2025 | https://doi.org/10.1371/journal.pgen.1011889

Correction: Hsp90 mutants with distinct defects provide novel insights into cochaperone regulation of the folding cycle

Rebecca Mercier, Danielle Yama, Paul LaPointe, Jill L. Johnson

PLOS Genetics: published September 4, 2025 | https://doi.org/10.1371/journal.pgen.1011850

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Correction: Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila

Kun Wu, Yiming Tang, Qiaoqiao Zhang, Zhangpeng Zhuo, Xiao Sheng, Jingping Huang, Jie’er Ye, Xiaorong Li, Zhiming Liu, Haiyang Chen

PLOS Genetics: published September 4, 2025 | https://doi.org/10.1371/journal.pgen.1011846

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Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics

Ke Xu, Nathaniel Maydanchik, Bowei Kang, Jianhai Chen, Qixiang Chen, Gongyao Xu, Shinya Tasaki, David A. Bennett, Lin S. Chen

PLOS Genetics: published September 11, 2025 | https://doi.org/10.1371/journal.pgen.1011819

Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance

Vivaswat Shastry, Marco Musiani, John Novembre

PLOS Genetics: published September 16, 2025 | https://doi.org/10.1371/journal.pgen.1011612

A method for identifying local adaptation in structured populations

Isabela do O, Oscar E Gaggiotti, Pierre de Villemereuil, Jerome Goudet

PLOS Genetics: published September 23, 2025 | https://doi.org/10.1371/journal.pgen.1011871