Towards a transcriptomic biomarker for the classification of melanocytic neoplasms

Elizabeth S. Borden, Colin T. Hastings, Nithish Prakash, Tyler Kuo, Edgar Tapia, Michael Yozwiak, Paul Sagerman, Danielle Vargas de Stefano, Kenneth H. Buetow, Melissa A. Wilson, Clara Curiel-Lewandrowski, Hsiao-Hui Sherry Chow, Bonnie J. LaFleur, Karen Taraszka Hastings

PLOS Genetics: published October 3, 2025 | https://doi.org/10.1371/journal.pgen.1011869

A high-resolution crossover landscape in Drosophila santomea reveals rapid and concerted evolution of multiple properties of crossing over control

Ana Llopart, Nikale Pettie, Abigail Ryon, Josep M. Comeron

PLOS Genetics: published October 6, 2025 | https://doi.org/10.1371/journal.pgen.1011885

Immunophenotypic changes in the tumor and tumor microenvironment during progression to multiple myeloma

Isabelle Bergiers, Murat Cem Köse, Sheri Skerget, Milan Malfait, Nele Fourneau, Jenna-Claire Ellis, Greet Vanhoof, Tina Smets, Bie Verbist, Dries De Maeyer, Jeroen Van Houdt, Koen Van der Borght, Raluca Verona, Bradley Heidrich, William Kurth, Michel Delforge, Nathalie Meuleman, Jan Van Droogenbroeck, Philip Vlummens, Christoph J. Heuck, Yves Beguin, Nizar Bahlis, Tineke Casneuf, Jo Caers

PLOS Genetics: published October 7, 2025 | https://doi.org/10.1371/journal.pgen.1011848

PP6 phosphatase and Elongator contribute to kinesin 5-dependent spindle assembly by controlling microtubule regulators levels

Laura Marín, Jorge Castro-Sangrador, Marta Hoya, Shara Tello, Pedro M. Coll, Javier Encinar del Dedo, Alfonso Fernández-Álvarez, Juan C. Ribas, Phong T. Tran, Sergio A. Rincon

PLOS Genetics: published October 7, 2025 | https://doi.org/10.1371/journal.pgen.1011596

Convergent evolution of H4K16ac-mediated dosage compensation in the ZW species Artemia franciscana

Frederic Zimmer, Annika Maria Fox, Qiaowei Pan, Frank Rühle, Peter Andersen, Ann-Kathrin Huylmans, Tanja Schwander, M. Felicia Basilicata, Claudia Isabelle Keller Valsecchi

PLOS Genetics: published October 9, 2025 | https://doi.org/10.1371/journal.pgen.1011895

Probing the molecular determinants of Ty1 retrotransposon restriction specificity in yeast

Sean L. Beckwith, Matthew A. Cottee, J. Adam Hannon-Hatfield, Abigail C. Newman, Emma C. Walker, Justin R. Romero, Jonathan P. Stoye, Ian A. Taylor, David J. Garfinkel

PLOS Genetics: published October 9, 2025 | https://doi.org/10.1371/journal.pgen.1011898

A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition

Alberto Ballin, Véronique Albanèse, Samia Miled, Véronique Legros, Guillaume Chevreux, Agathe Verraes, Anne Friedrich, Sébastien Léon

PLOS Genetics: published October 9, 2025 | https://doi.org/10.1371/journal.pgen.1011896

The chitin synthase regulator CSR-3 promotes cellular integrity during cell-cell fusion in the filamentous ascomycete fungus Neurospora crassa

Stephanie Herzog, Tanja N. Sedlacek, Kristian D. R. Roth, Manuel Reuning, Ulrike Brandt, André Fleißner

PLOS Genetics: published October 10, 2025 | https://doi.org/10.1371/journal.pgen.1011891

VAB-8/KIF26, LIN-17/Frizzled, and EFN-4/Ephrin control distinct stages of posterior neuroblast migration downstream of the MAB-5/Hox transcription factor in Caenorhabditis elegans

Vedant D. Jain, Erik A. Lundquist

PLOS Genetics: published October 10, 2025 | https://doi.org/10.1371/journal.pgen.1011906

Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics

Nathan Roberge, Nathan Yuen, Hanjeong Harvey, Taylor J. Ellison, Courtney K. Ellison, Lori L. Burrows

PLOS Genetics: published October 13, 2025 | https://doi.org/10.1371/journal.pgen.1011802

Genotype-phenotype characterization and functional reconstitution of pathogenic β-catenin variants from CTNNB1 syndrome patients

Caroline E. Nunes-Xavier, Mercè Pallarès-Sastre, Ana Rodríguez-Ramos, Sonia Bañuelos, Irune Cortajarena, Fabio Cavaliere, Cynthia Ruiz-Espinoza, Isabel Llano-Rivas, Maitane García, Imanol Amayra, Rafael Pulido

PLOS Genetics: published October 13, 2025 | https://doi.org/10.1371/journal.pgen.1011907

Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci

E. Renee Matthews, Raodatullah O. Abodunrin, John D. Hurley, Sayan Paul, José A. Gutiérrez, Alyssa R. Bogar, Michelle C. Ward

PLOS Genetics: published October 14, 2025 | https://doi.org/10.1371/journal.pgen.1011900

Tulp3 quantitative alleles titrate requirements for viability, brain development, and kidney homeostasis but do not suppress Zfp423 mutations in mice

Corinne A. McCoy, Dorothy Concepcion, Mark G. Mezody, Raquel Z. Lara, Ojas Deshpande, Catherine Liang, Renee Long, Bruce A. Hamilton

PLOS Genetics: published October 15, 2025 | https://doi.org/10.1371/journal.pgen.1011911

A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos

Axelle Loriot, Julie Devis, Laurent Gatto, Charles De Smet

PLOS Genetics: published October 15, 2025 | https://doi.org/10.1371/journal.pgen.1011734

The intracellular symbiont Wolbachia alters Drosophila development and metabolism to buffer against nutritional stress

Amelia R. I. Lindsey, Jason M. Tennessen, Michael A. Gelaw, Megan W. Jones, Audrey J. Parish, Irene L. G. Newton, Travis Nemkov, Angelo D’Alessandro, Madhulika Rai, Nicole Stark

PLOS Genetics: published October 15, 2025 | https://doi.org/10.1371/journal.pgen.1011905

Stn1 supports Mec1 function in protecting stalled replication forks from degradation

Erika Casari, Flavio Corallo, Luca Edoardo Milani, Renata Tisi, Maria Pia Longhese

PLOS Genetics: published October 15, 2025 | https://doi.org/10.1371/journal.pgen.1011917

ASPPs multimerize protein phosphatase 1

Derek T. Wei, Kayleigh N. Morrison, Gwendolyn M. Beacham, Erika Beyrent, Cyrus A. Habas, Ying Zhang, Laurence Florens, Gunther Hollopeter

PLOS Genetics: published October 16, 2025 | https://doi.org/10.1371/journal.pgen.1011731

Rare diseases load through the study of a regional population

Élisa Michel, Claudia Moreau, Laurence Gagnon, Mylène Gagnon, Josianne Leblanc, Jessica Tardif, Lysanne Girard, Jean Mathieu, Cynthia Gagnon, Mathieu Desmeules, Jean-Denis Brisson, Luigi Bouchard, Simon L. Girard

PLOS Genetics: published October 16, 2025 | https://doi.org/10.1371/journal.pgen.1011876

Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex

Gregory A. Harrison, Aimee Shen

PLOS Genetics: published October 21, 2025 | https://doi.org/10.1371/journal.pgen.1011746

Loss of meiotic double strand breaks triggers recruitment of recombination-independent pro-crossover factors in C. elegans spermatogenesis

JoAnne Engebrecht, Aashna Calidas, Qianyan Li, Angel Ruiz, Pranav Padture, Neeraj Bhavani Aniyan Bhavana, Consuelo Barroso, Enrique Martinez-Perez, Nicola Silva

PLOS Genetics: published October 22, 2025 | https://doi.org/10.1371/journal.pgen.1011763

C. elegans SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1

Keshav Jha, Alexander Woglar, Coralie Busso, Georgios N. Hatzopoulos, Tatiana Favez, Pierre Gönczy

PLOS Genetics: published October 22, 2025 | https://doi.org/10.1371/journal.pgen.1011912

Expanded diversity of pedinophytes provides a window into the evolution of the genetic code in organelles

Dovilė Barcytė, David Žihala, Marek Eliáš

PLOS Genetics: published October 22, 2025 | https://doi.org/10.1371/journal.pgen.1011901

A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat

Tingting Jiang, Duo Su, Jing Ke, Xin Dai, Maohua Wang, Yan Wang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Li Li, Honping Zhang, Linjie Wang

PLOS Genetics: published October 23, 2025 | https://doi.org/10.1371/journal.pgen.1011915

Paf1C regulates the Neurospora circadian clock by promoting the transcription elongation of frequency

Mengmeng Zhou, Yunpeng Zhao, Yubo He, Zeyu Duan, Xiao Liu, Qun He

PLOS Genetics: published October 23, 2025 | https://doi.org/10.1371/journal.pgen.1011926

Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies

Kashyap Chhatbar, Adrian Bird, Guido Sanguinetti

PLOS Genetics: published October 23, 2025 | https://doi.org/10.1371/journal.pgen.1011908

TSSKL is essential for sperm mitochondrial morphogenesis and male fertility in moths

Xia Xu, Lu Zhu, Xiaomiao Xu, Jine Chen, Xin Du, Linbao Zhu, Shaofang Yu, Lansa Qian, Xingchuan Jiang, Lijun Zhou, Yongcheng Dong, Yongqiang Wang, Yongping Huang, Yaohui Wang

PLOS Genetics: published October 24, 2025 | https://doi.org/10.1371/journal.pgen.1011914

The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration

Joshua Shing Shun Li, Ying Liu, Ah-Ram Kim, Mujeeb Qadiri, Jun Xu, Baolong Xia, Richard Binari, John M. Asara, Yanhui Hu, Norbert Perrimon

PLOS Genetics: published October 27, 2025 | https://doi.org/10.1371/journal.pgen.1011910

TERT translocation to mitochondria: Exploring its role in mitochondrial homeostasis

Jessica Marinaccio, Erica Rossi, Emanuela Micheli, Ion Udroiu, Nicolò Baranzini, Gaia Marcolli, Antonella Sgura

PLOS Genetics: published October 27, 2025 | https://doi.org/10.1371/journal.pgen.1011923

Genome-wide analysis identifies susceptibility loci for heart failure and nonischemic cardiomyopathy subtype in the East Asian populations

Yi Han, Yun Hong, Yan Gao, Jiapeng Lu, Bowang Chen, Lihua Zhang, Xiaofang Yan, Ying Sun, Liping Zhang, Jiangling Liu, Hao Dai, Libo Hou, Xi Li, Jing Li

PLOS Genetics: published October 27, 2025 | https://doi.org/10.1371/journal.pgen.1011897

High-throughput conjugation reveals strain specific recombination patterns enabling precise trait mapping in Escherichia coli

Thibault Corneloup, Juliette Bellengier, Isabelle Rosinski-Chupin, Mélanie Magnan, Arsh Chavan, Benoit Gachet, Zoya Dixit, Coralie Pintard, Alexandra Baron, Doreen Toko, Amaury Lambert, Alaksh Choudhury, Olivier Tenaillon

PLOS Genetics: published October 30, 2025 | https://doi.org/10.1371/journal.pgen.1011636

Dosage-dependent regulation of embryonic diapause by sorbitol dehydrogenase in the silkworm, Bombyx mori

Dongbin Chen, Dehong Yang, Xin Fu, Haixu Bian, Yongping Huang, Yanqun Liu, Zulian Liu

PLOS Genetics: published October 30, 2025 | https://doi.org/10.1371/journal.pgen.1011933

Correction: Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition

The PLOS Genetics Staff

PLOS Genetics: published October 24, 2025 | https://doi.org/10.1371/journal.pgen.1011922

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1. Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition

Retraction: DNA Damage, Homology-Directed Repair, and DNA Methylation

The PLOS Genetics Editors

PLOS Genetics: published October 27, 2025 | https://doi.org/10.1371/journal.pgen.1011921

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1. RETRACTED: DNA Damage, Homology-Directed Repair, and DNA Methylation