Current Issue
- September 30, 2025
- vol. 122
- no. 39
- The Ebola virus (EBOV) genome encodes for a limited number of proteins and depends on host factors to facilitate viral replication. Identification and characterization of host–viral interactions are needed to define infection, resolution, and ...Ebola virus (EBOV) is a nonsegmented, negative-sense virus (NNSV) with a single-stranded RNA genome. EBOV encodes for a limited number of proteins and thus depends on host factors to facilitate viral replication and pathogenesis. Of the virus-encoded ...
- Many transcription factors (TFs) can activate and repress gene transcription. Traditionally, this switch in function has been attributed to binding different coregulatory proteins. In this work, we explore a different mechanism, where a TF ...Transcription factors (TFs) can be both activators and repressors of gene transcription. This can manifest as “duality,” where the transcriptional response increases (activation) with TF concentration in one context but decreases (repression) in another ...
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- Sexual partnerships can have a profound impact on societal well-being and evolution. Their absence can be detrimental to mental health and can lead to behavioral problems. Importantly, lifetime sexlessness offers an insightful measure for ...Romantic (typically sexual) relationships are important to personal, physical, mental, social, and economic well-being, and to human evolution. Yet little is known about factors contributing to long-term lack of intimate relationships. We investigated ...
- The question of whether a person’s position among siblings has a lasting impact on that person’s life course has fascinated both the scientific community and the general public for >100 years. By combining large datasets from three national ...This study examined the long-standing question of whether a person’s position among siblings has a lasting impact on that person’s life course. Empirical research on the relation between birth order and intelligence has convincingly documented that ...
- Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
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