Current Issue
- October 14, 2025
- vol. 122
- no. 41
- The sequence of amino acids within a protein dictates its structure and function. Protein engineering campaigns seek to discover protein sequences with desired functions. Data-driven models of the sequence–function relationship can be used to ...Deep generative models have demonstrated success in learning the protein sequence to function relationship and designing synthetic sequences with engineered functionality. We introduce the Protein Transformer Variational AutoEncoder (ProT-VAE) as an ...
- There is a pressing need to develop nonopioid treatments for pain. In the diseased colon, proteases that activate PAR2 on nociceptors and colonocytes evoke pain. Since PAR2 endosomal signaling underlies pain, PAR2 in endosomes is a relevant ...Although many internalized G protein-coupled receptors (GPCRs) continue to signal, the mechanisms and outcomes of intracellular GPCR signaling are uncertain due to the challenges of measuring organelle-specific signals and of selectively antagonizing ...
PNAS is one of the world's most-cited and comprehensive multidisciplinary scientific journals.
The Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS), is an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences. The journal is global in scope and submission is open to all researchers worldwide.
In the News
- Sexual partnerships can have a profound impact on societal well-being and evolution. Their absence can be detrimental to mental health and can lead to behavioral problems. Importantly, lifetime sexlessness offers an insightful measure for ...Romantic (typically sexual) relationships are important to personal, physical, mental, social, and economic well-being, and to human evolution. Yet little is known about factors contributing to long-term lack of intimate relationships. We investigated ...
- Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
- The recent surge in generative AI has introduced exciting possibilities for computational chemistry. Generative AI methods have made significant progress in sampling molecular structures across chemical species, developing force fields, and speeding up ...
Front Matter
Featured QnAs
Recent Issues
Submit to PNAS
Submit to the Proceedings of the National Academy of Sciences (PNAS) and have your research discovered by millions of researchers in the biological, physical, and social sciences.
Submit your manuscript















