Table Of Contents Page, PNAS Volume 123, Number 22
Special Feature
Polyploidy and Stress
In native environments, organisms are faced with an array of acute or chronic stresses.
These stresses include toxins, pathogens, and physical injury. An increasingly recognized
response to diverse stresses is whole genome doubling or polyploidy. This ...
Escalating pressures of global climate change necessitate developing agricultural
systems and crop varieties with enhanced resilience. Polyploidy, the state of possessing
multiple complete sets of chromosomes arising from whole genome duplication (WGD),
...
Polyploidy, also known as whole genome duplication, is a major evolutionary force
in plants, driving diversification and the generation of novel phenotypic variation,
including superior abiotic and biotic stress tolerance. The enhanced stress resilience
...
Polyploidization, the consequence of genome doubling, is a macromutation that reshapes
genomes, phenotypes, and ecological interactions. Polyploidization often results in
novel phenotypes, including alterations in size, physiology, biochemistry, and ...
We recently found that newly formed tetraploid (4N) cells in culture quickly lose
extra centrosomes after whole genome doubling (WGD). This is inconsistent with the
high incidence of centrosome number abnormalities in human cancers and with the ...
Cell cycle–dependent and independent mechanisms lead to the generation of mononucleated
and multinucleated polyploid cells. The more than doubling of a cell’s nuclear genome
by endoreplication has been found to be an adaptation to genotoxic stress, ...
Various states of cardiomyocyte (CM) polyploidy have been associated with cardiac
injury responses, including regeneration and heart failure. However, our understanding
of the comprehensive mechanisms governing CM ploidy and its relationship with heart
...
Cryptococcus neoformans is a fungal pathogen of humans that causes life-threatening meningoencephalitis.
During infection, enlarged, polyploid titan cells are produced that promote persistence
in the host, in part by resisting phagocytosis; under stress ...
Polyploidy, the presence of more than two sets of chromosomes, has evolved many times
across the tree of life, yet we still do not know why some polyploid lineages persist
while most go extinct. The establishment of polyploid populations is often reported
...
This Week in PNAS
Opinion
Profile
The Royal Swedish Academy of Sciences awarded the 2025 Nobel Prize in Physics jointly
to John Clarke, Michel H. Devoret, and John M. Martinis for their foundational discovery
of macroscopic quantum mechanical tunneling and energy quantization in ...
Commentaries
Letters
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Reply to Romano and De Dreu: Why violent extremism cannot be reduced to laboratory games
Brief Reports
The identification of SRD5A3, a causative gene for congenital disorders of glycosylation (CDGs), together with
its yeast ortholog DFG10, established the prevailing model that dolichol is synthesized from polyprenol in
a single step. Subsequently, a recent ...
Sudden, global reversals in shell coiling direction are a striking and recurrent feature
in the fossil record of planktonic foraminifera (marine zooplankton), yet their evolutionary
significance has been a mystery. Because coiling direction is a simple, ...
Desert ants and foraging rodents return home along surprisingly direct paths after
meandering outward journeys. Traditional path integration models explain this through
cumulative vector addition, yet struggle to account for the neurobiological mechanisms
...
Physical Sciences
Applied Mathematics
The complex formations exhibited by schooling fish have long been the object of fascination
for biologists and physicists. However, the physical and sensory mechanisms leading
to organized collective behavior remain elusive. On the physical side in ...
Fluidic oscillation and flow bistability—classical signatures of nonlinear fluid dynamics—typically
occur at high Reynolds numbers, whereas the Rosensweig instability, manifested as
spike formation on a ferrofluid surface under a magnetic field, reflects ...
The functioning of complex systems depends on the coordination of diverse components,
often supported by regulatory structures that incur costs. In human organizations,
such costs manifest as administrative burden, which has been rising despite often
...
Applied Physical Sciences
Moiré superlattices in two-dimensional (2D) materials have been realized through lattice
mismatch or rotational misalignment between atomic layers. Here, we extend moiré formation
to heterostrain in transition metal dichalcogenides using a scalable ...
Colloidal photonic glasses are attractive as dye-free, solution-processable pigments
that show weak angle dependence, but their red hues are notoriously washed out, because
single-particle Rayleigh/Mie scattering produces a strong blue background (form ...
The excess vibrational states relative to the Debye model of solids, referred to as
the boson peak (BP), are a key feature of glasses and amorphous materials. These excess
states underlie anomalous thermal properties such as excess specific heat and low
...
Biophysics and Computational Biology
The processivity of Structural Maintenance of Chromosome complexes defines the characteristic
run length and lifetime of loop extrusion events, which set up the large-scale architecture
of chromosomes. We introduce an active, non-Markovian mechanistic ...
Epithelial cysts are minimal structures involved in morphogenesis. They are fluid-filled
cavities surrounded by an epithelial monolayer. During development, cyst grow and
their interactions shape organs. While their growth dynamics as single structures
...
Cells use lamellipodia, thin actin-rich membrane protrusions, to probe the mechanical
properties of their microenvironment. During mechanosensing, lamellipodia often exhibit
dynamic instability in the form of protrusion-retraction cycles. However, how ...
Although monoculture is a common practice, its fragility, high input requirements,
and significant environmental impact underscore the need to seek alternatives. Polyculture,
inspired by naturally occurring plant communities, could be one such ...
Spirostomum is a giant unicellular ciliate that contracts to a quarter of its body length in
less than five milliseconds, achieving an order of magnitude higher fractional shortening
rate than actomyosin-based systems. This ultrafast contraction is ...
The voltage-gated proton (Hv1) channel is crucial in regulating cellular pH, yet the mechanism underlying proton
permeation remains controversial. A deeper understanding of the differences between
the channel’s active and resting states is essential for ...
Chemistry
The ADP-ribosylation of proteins is a versatile, reversible, posttranslational modification
involved in the dynamic regulation of numerous cellular processes. Human ADP-ribosyltransferase
1 (hsART1, EC: 2.4.2.31) is a membrane-associated, GPI-anchored, ...
New particle formation (NPF) in the marine upper troposphere sustains one of the largest
global aerosol reservoirs that seeds cloud condensation nuclei in the lower troposphere,
with far-reaching implications for Earth’s radiative balance and climate. ...
Computer Sciences
Large language models (LLMs) are rapidly changing academic research, raising questions
of who is adopting these tools and under what conditions. This article analyzes full
texts of 7.3 million journal articles published from 2020–2025 by four major ...
One Health issues, such as the spread of highly pathogenic avian influenza, present
unique challenges at the human–animal–environmental interface. Ongoing H5N1 outbreaks
underscore the urgent need for comprehensive modeling efforts that capture the ...
Earth, Atmospheric, and Planetary Sciences
Human activities amplify climate-induced greenhouse gas emissions from small water
bodies (SWBs), creating critical but unquantified feedback in the global carbon cycle.
Here, by training machine learning models on 470 field observations and upscaling
to ...
On Earth, atmospheric oxygen is inferred to have risen over three major intervals
before reaching modern levels, with each interval having a profound impact on the
evolution of the biosphere. However, the principal driver behind these stepwise increases
...
Self-accelerating turbidity currents (SATCs) are hypothesized to be the primary mechanism
for transporting vast amounts of sediment to the deep ocean. However, theoretical
predictions of SATCs have preceded field observations by decades, leaving a ...
Aerosol acidity (pH) is a fundamental property governing atmospheric multiphase chemistry,
as it influences pollutant partitioning, secondary organic aerosol formation, and
trace metal solubility. Thermodynamic models typically assume the internal ...
Convection in porous materials governs heat transport across scales ranging from planetary
subsurface systems to engineered cooling devices. While the onset of buoyancy-driven
flow is well described by linear stability theory within a porous-continuum ...
Nanophase metallic iron (npFe0) in lunar soils is a key indicator for understanding the space weathering mechanisms
of airless bodies. However, the detailed three-dimensional (3D) spatial topology and
distribution of layered npFe0 have rarely been ...
During the terminal Pleistocene through Holocene, changes in dietary diversity signaled
fundamental shifts in the way humans related to food resources in many parts of the
globe. To understand local and regional dietary variation across the transition to
...
Engineering
Aqueous zinc (Zn) batteries are among the most promising candidates for safe, low-cost,
and sustainable grid-scale energy storage. However, their practical application is
significantly constrained by inhomogeneous Zn electrodeposition and the competitive
...
Filamentous entanglements such as textiles achieve resilience and toughness through
topology rather than material composition alone. Yet architected materials rarely
exploit dense interlooping and sliding contacts to achieve extraordinary physical
...
Growing global interest in gold (Au) has spurred the development of adsorption processes
as sustainable technologies for effective Au recovery from industrial waste. However,
the adsorbents used in such processes often require complex fabrication ...
Environmental Sciences
Soil is fundamental to sustaining life on Earth, providing ecosystem services, regulating
climate, and playing a central role in global food systems. In the last decades, due
to human activities and climate change, soils worldwide have experienced ...
Physics
Recurrence time quantifies the duration required for a physical system to return to
its initial state, playing a pivotal role in understanding the predictability of complex
systems. In quantum systems with subspace measurements, recurrence times are ...
Pair density wave (PDW) exhibits periodic amplitude and sign modulations of the superconducting
order parameter. Such a pairing state has long been proposed to be highly sensitive
to nonmagnetic scattering, but its experimental realization remains ...
Sustainability Science
Human activities amplify climate-induced greenhouse gas emissions from small water
bodies (SWBs), creating critical but unquantified feedback in the global carbon cycle.
Here, by training machine learning models on 470 field observations and upscaling
to ...
Social Sciences
Anthropology
During the terminal Pleistocene through Holocene, changes in dietary diversity signaled
fundamental shifts in the way humans related to food resources in many parts of the
globe. To understand local and regional dietary variation across the transition to
...
The southern coast of Europe has been at the center of archaeological debates contrasting
the social and cognitive capabilities of Neanderthals and modern humans. Early evidence
of marine resource exploitation by Neanderthals in this region challenged ...
Economic Sciences
Large Language Models (LLMs) such as ChatGPT are transforming how scientists conduct
and validate research, offering promise as tools to improve scientific reproducibility.
However, computational reproducibility and error detection remain expensive and ...
While the effects of the transition to parenthood are well researched, less is known
about how the transition to grandparenthood affects health and labor market outcomes.
Using comprehensive Norwegian register data covering the entire population born ...
Using the staggered rollout of China’s one-child policy (OCP) across provinces and
birth cohorts as a quasi-natural experiment, we demonstrate that differential fertility
between richer and poorer households exacerbates intergenerational income ...
Political Sciences
Sycophants praise and support leaders’ proposals to gain personal and professional
advantage. A rational sycophant is an advisor who supports actions they expect to
be harmful even when rewards and punishments for good and bad advice are equal in
...
Psychological and Cognitive Sciences
Cultural evolution allows ideas and technologies to accumulate across generations,
reaching their most complex and open-ended form in humans. While social learning enables
the transmission of such innovations, the cognitive processes that generate them ...
Popularity is a key marker of social status, yet the phenomena that support its emergence
within newly forming social groups remain unclear. We combined functional neuroimaging
and longitudinal school-wide social network analysis to track adolescents ...
The advancement of science depends on rigorous tests of competing hypotheses, yet
many disputes are left unresolved. Adversarial collaboration—where opposing scientists
jointly design decisive tests—is one proposed solution. We examine whether large ...
Long-duration space missions expose crews to extreme psychological and social stressors
due to prolonged isolation and confinement. To examine how such conditions impact
individual and team functioning, we studied a 10-mo Antarctic overwintering mission
...
Our cognitive processes are largely shaped by what is present in our environment,
while absences are often overlooked. This fundamental tendency of the human mind can
lead to a significant social bias: individuals frequently fail to notice the absence
of ...
Individuals are motivated to increase their social status. To succeed in this pursuit,
people must track information about others in their social sphere, monitor group norms,
and adjust their behavior strategically. This study employed functional MRI and ...
Social Sciences
The functioning of complex systems depends on the coordination of diverse components,
often supported by regulatory structures that incur costs. In human organizations,
such costs manifest as administrative burden, which has been rising despite often
...
Large language models (LLMs) are rapidly changing academic research, raising questions
of who is adopting these tools and under what conditions. This article analyzes full
texts of 7.3 million journal articles published from 2020–2025 by four major ...
Do social networks and peer influence shape major life decisions in polarized settings?
We explore this question by examining how peers influenced the allegiances of West
Point cadets during the American Civil War. Leveraging quasi-random variations in
...
Sustainability Science
As urbanization accelerates, urban blue and green spaces are increasingly recognized
as critical nature-based solutions for enhancing human well-being, delivering climate,
environmental, and psychological benefits. Yet, the mechanisms by which access to
...
Land conservation initiatives worldwide are poised to continue rapid growth. Ranging
in scale, scope, and mechanisms, these efforts include area-based conservation, incentive-based
protection, and community collective management. Evidence from across ...
Biological Sciences
Agricultural Sciences
Although monoculture is a common practice, its fragility, high input requirements,
and significant environmental impact underscore the need to seek alternatives. Polyculture,
inspired by naturally occurring plant communities, could be one such ...
Anthropology
The southern coast of Europe has been at the center of archaeological debates contrasting
the social and cognitive capabilities of Neanderthals and modern humans. Early evidence
of marine resource exploitation by Neanderthals in this region challenged ...
Applied Biological Sciences
mRNA-based gene editing therapeutics offer the potential to permanently cure diseases
but are hindered by suboptimal delivery platforms. Here, we devise a robust combinatorial
chemistry for the plug-and-play assembly of structurally diverse biodegradable ...
Biochemistry
The ADP-ribosylation of proteins is a versatile, reversible, posttranslational modification
involved in the dynamic regulation of numerous cellular processes. Human ADP-ribosyltransferase
1 (hsART1, EC: 2.4.2.31) is a membrane-associated, GPI-anchored, ...
Engineering CRISPR-Cas systems for improved or altered function is critical to both
research and therapeutic applications. Unfortunately, most optimization, especially
directed evolution in bacterial hosts, fails to capture the functional requirements
of ...
5-Methylpyrimidine dioxygenases (5mYOXs) are iron (II)/2-oxoglutarate-dependent enzymes
that catalyze the postreplicative oxidation of DNA 5-methylpyrimidines. Here, we define
two subclasses of phage thymine (T) 5mYOXs: a stand-alone enzyme and a second ...
Severing enzymes nanodamage microtubules by extracting tubulin subunits. This extraction
is accompanied by spontaneous repair with soluble tubulin. Here, we show that GTP-,
and not GDP–tubulin, incorporates preferentially at nanodamage sites where it ...
Self-assembling protein cages are valuable nanoscale containers for biotechnology
and medical applications. Two-component systems are especially attractive due to their
potential for functional complexity. In this study, we demonstrate that the subunits
...
Biophysics and Computational Biology
The complex formations exhibited by schooling fish have long been the object of fascination
for biologists and physicists. However, the physical and sensory mechanisms leading
to organized collective behavior remain elusive. On the physical side in ...
The processivity of Structural Maintenance of Chromosome complexes defines the characteristic
run length and lifetime of loop extrusion events, which set up the large-scale architecture
of chromosomes. We introduce an active, non-Markovian mechanistic ...
Amyloid formation and liquid–liquid phase separation (LLPS) are two important phenomena
in cellular biology, linked to both normal physiological functions and various pathologies.
Here, we present a computational framework that scores amyloid propensities ...
Accurately predicting the fitness effects of high-order mutations is a grand challenge
in understanding and engineering proteins. Existing models, including pretrained protein
language models, struggle to capture the multiresidue interactions that govern ...
Bacterial fimbrial adhesins such as FimH are critical for host colonization and persistence
under the mechanical forces encountered at sites of infection such as the urinary
tract. The molecular mechanisms by which FimH, a key virulence factor of ...
Cell Biology
Spirostomum is a giant unicellular ciliate that contracts to a quarter of its body length in
less than five milliseconds, achieving an order of magnitude higher fractional shortening
rate than actomyosin-based systems. This ultrafast contraction is ...
The voltage-gated proton (Hv1) channel is crucial in regulating cellular pH, yet the mechanism underlying proton
permeation remains controversial. A deeper understanding of the differences between
the channel’s active and resting states is essential for ...
Lysine lactylation regulates protein fate and function across diverse biological processes.
While PD-L1 has been widely studied posttranslationally, the role of its lactylation
and the responsible enzyme have remained poorly studied. Here, we identify ...
Fatty acids undergo re-esterification to form triglycerides or are directly oxidized
for energy production following absorption. Fatty acid binding protein 1 (FABP1),
a key transporter highly expressed in both hepatic and intestinal tissues, directs
the ...
Interpreting missense variants in highly conserved, paralog-rich gene families remains
a major barrier to understanding protein function and advancing precision medicine.
Here, we combine comprehensive mutagenesis, high-content live-cell imaging, and ...
Neurofibromin, the protein product of the neurofibromatosis type 1 (NF1) gene, requires the direct binding interaction with SPRED to negatively regulate
the RAS-MAPK pathway. Although the region of neurofibromin that stimulates the intrinsic
GTPase ...
Developmental Biology
Rapid activation of ERK (extracellular signal-regulated kinase) signaling drives transcriptional
responses to injury across metazoans. Yet, it is unclear whether key aspects of ERK
as a wound signal—its upstream inputs, activating cell type(s), and ...
CRISPR/Cas9-based mosaic analysis is a powerful tool for in vivo genetics but is limited
by cytotoxicity and mutagenesis associated with DNA double-strand breaks. Here, we
establish Cas9-derived nickases as safer and more reliable alternatives for ...
Endogenous bioelectric currents regulate development and regeneration, but their influence
on organismal longevity and stem cell–mediated repair is not well understood. We demonstrate
that a brief, clinically safe pulse of electrical current (PEC) ...
Ecology
Identifying overarching processes that maintain biodiversity in natural communities
remains a challenge in ecology. Although functional traits help explain regional species
distributions, they often fall short at the local community level. We investigate
...
The escalating biodiversity crisis underscores the urgent need for a unified framework
that links the mechanisms maintaining biodiversity to its functional consequences.
However, studies of species coexistence and biodiversity effects on ecosystem ...
Environmental Sciences
As urbanization accelerates, urban blue and green spaces are increasingly recognized
as critical nature-based solutions for enhancing human well-being, delivering climate,
environmental, and psychological benefits. Yet, the mechanisms by which access to
...
Evolution
Cultural evolution allows ideas and technologies to accumulate across generations,
reaching their most complex and open-ended form in humans. While social learning enables
the transmission of such innovations, the cognitive processes that generate them ...
Many organisms reproduce through noncanonical modes such as parthenogenesis or hybridogenesis
(clonal transmission of one parent’s chromosomes), but whether these arise abruptly
or stepwise from each other remains unclear. We address this in the stick-...
High-latitude terrestrial ecosystems are commonly viewed as marginal environments
to deep-time evolutionary innovation, yet their role in shaping biotic dispersal,
diversification, and survivorship remains poorly understood. The Upper Cretaceous
Prince ...
Predicting the genetic consequences of population decline is a major problem in conservation
genomics. Time lags following demographic bottlenecks can delay genomic erosion and
make it difficult to determine a population’s current and future risk, ...
Biological communities are complex, dynamic systems that underpin ecosystem functionality,
yet their long-term dynamics and predictability remain poorly understood. Understanding
how Darwinian evolution shapes these systems through eco-evolutionary ...
Genetics
DNA G-quadruplexes (G4s) are non-B-form secondary DNA structures that are prevalent
at key regulatory regions in mammalian genome and are highly conserved across evolution.
However, the mechanisms by which G4s contribute to distinct facets of genome ...
Immunology and Inflammation
Phosphatidylethanolamine (PE) biosynthesis is critical for membrane biology and cellular
homeostasis. However, its specific role in antiviral innate immunity remains poorly
understood. Here, we demonstrate that inhibition of phosphoethanolamine ...
Immunity following infection with the four dengue virus serotypes (DENV1-4) remains
difficult to define. Reports of individuals being reinfected with the same serotype
challenge the paradigm that infection induces lifelong homotypic immunity. However,
the ...
Medical Sciences
The prevalence of Mycobacterium abscessus (MABS) infections in people with cystic fibrosis (pwCF) is increasing. Macrophages
are key phagocytic cells that recognize bacteria via cell surface receptors, engulf them into phagosomes, and then utilize diverse ...
Liver fibrosis, marked by an abnormal buildup of extracellular matrix (ECM), poses
a major health threat. Myofibroblasts, predominantly derived from hepatic stellate
cells (HSCs) and portal fibroblasts, are the primary drivers of ECM synthesis. Fibroblast
...
Microbiology
Nitrogen exchange between plants and insects is a major component of ecosystem nitrogen
cycling. Endophytic insect pathogenic fungi transfer insect-derived nitrogen to plants
through symbiotic associations mediated by fungal mycelia, enabling plants to ...
EBV is associated with human B cell lymphomas, including Burkitt lymphomas (BLs),
diffuse large B cell lymphomas (DLBCLs), Hodgkin lymphomas (HLs), and Plasmablastic
lymphomas (PLs). EBV+ lymphomas in immunocompetent humans are usually derived from
...
Induction of RNA degradation in infected cells is a strategy used by many viruses
to promote efficient replication. Vaccinia virus, the prototype poxvirus and the vaccine
platform for smallpox and mpox, encodes two decapping enzymes to accelerate mRNA and
...
Bacteria often proliferate within confined spaces imposed by host tissues, extracellular
matrices, or their own biofilms where cells press against surrounding materials and
experience elevated mechanical stress. Whether these forces influence pathogen ...
Human cytomegalovirus (HCMV) establishes lifelong latency, during which immediate-early
(IE) gene expression is strongly repressed. IE1 and IE2 are considered master regulators
of the lytic cycle, yet it remains unclear whether their expression levels are ...
Neuroscience
Conscious thought is often treated as a special class of neural processing, distinct
from the nonconscious computations that guide most behavior. Here I offer a different
perspective, grounded in the neuroscience of decision-making. I argue that conscious
...
Maintaining balance requires a complex interplay between sensory and motor processes,
and this ability deteriorates with age, impairing daily life activities and contributes
to increased fall risks. Importantly, while cognitive-motor interference ...
Circadian rhythms are ubiquitous, and most of the organs in the body contain circadian
oscillators. The intestine comprises diverse cell types with distinct developmental
origins and physiological functions. However, which intestinal cells contain cell-...
Major depressive disorder (MDD) is characterized by symptom heterogeneity and sex
differences in prevalence. To gain insight into these sex differences, we utilized
the subchronic variable stress paradigm (SCVS) in which female mice are susceptible,
while ...
Motor learning involves the dynamic reconfiguration of brain activity across widely
distributed networks. Yet, the moment-to-moment evolution of the whole-brain functional
states underpinning this process remains unknown. Here, applying manifold-based ...
The ventromedial hypothalamus (VMH) is a key regulator of energy homeostasis, linking
central neural activity to peripheral metabolic function. Within the VMH, neurons
expressing steroidogenic factor-1 (SF-1; VMHSF1) are essential for regulating energy ...
Photovoltaic subretinal prosthesis can restore central vision in patients blinded
by age-related macular degeneration with letter acuity matching its 100 µm pixel size.
Improving resolution requires smaller pixels, but to still reach the target neurons,
...
As a basic unit of the nervous system, the sensory-motor reflex circuit is fast and
robust. However, it is not entirely clear how this robustness is achieved, given that
various genetic perturbations can alter the function of the sensory neurons. By ...
Long-term potentiation (LTP) is a lasting form of synaptic plasticity that can persist
for hours or even days. It is associated with structural changes in both the presynaptic
terminal and the postsynaptic spine. Presynaptically, the number and ...
Plant Biology
In bacteria, protein mistranslation can improve stress tolerance. Mitochondria and
plastids evolved from bacteria and use a prokaryotic-type expression machinery to
synthesize proteins. Interestingly, fungi and animal mitochondria are highly sensitive
to ...
Dietary deficiencies in essential micronutrients and other phytonutrients represent
a global health and economic burden, contributing to “hidden hunger” and chronic diseases.
While genome editing has been employed to improve individual nutritional traits ...
Psychological and Cognitive Sciences
Individuals are motivated to increase their social status. To succeed in this pursuit,
people must track information about others in their social sphere, monitor group norms,
and adjust their behavior strategically. This study employed functional MRI and ...
Reading is central to academic and vocational success. Some deaf children face reading
challenges due to limited access to spoken or signed language. Robust phonological
representations are key to reading development in hearing children. Spoken language
...
Sustainability Science
Soil is fundamental to sustaining life on Earth, providing ecosystem services, regulating
climate, and playing a central role in global food systems. In the last decades, due
to human activities and climate change, soils worldwide have experienced ...
Systems Biology
One Health issues, such as the spread of highly pathogenic avian influenza, present
unique challenges at the human–animal–environmental interface. Ongoing H5N1 outbreaks
underscore the urgent need for comprehensive modeling efforts that capture the ...
HHIP’s dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility
Genetic variants near Hedgehog interacting protein (HHIP) have been consistently associated with increased risk for chronic obstructive pulmonary
disease (COPD), the third leading cause of death worldwide. However, HHIP’s role in COPD pathogenesis remains ...
Corrections
Cover image: Pictured are fruit fly epithelial cells that have become polyploid through cell fusion. A collection of articles in the Polyploidy and Stress Special Feature explores recent research on polyploidy, or the possession of three or more complete sets of chromosomes, a widespread biological feature that may function as a response to stress in cells, tissues, and diverse organisms. Together, the articles highlight the role of polyploidy in molecular, cellular, organismal, and ecological processes, with implications for basic biology, medicine, agriculture, and the bioeconomy. See the Introduction to the Special Feature, e2607049123. Image credit: Minqi Shen and Vicki P. Losick (Boston College, Chestnut Hill, MA).
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