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Brought to you by BioInnovation Institute & Science Prize for Innovation VOLUME 385 | ISSUE 6704 | 5 JUL 2024 Editorial Editorial American academic freedom is in peril By Ryan Calo, Kate Starbird Read more News In Brief News at a glance Read more In Depth  |  Energy Giant fusion project in big trouble By Daniel Clery ITER operations delayed to 2034, with energy-producing reactions expected 5 years later Read more In Depth  |  Conservation Does wildlife rehabilitation work? No one knows for sure By Sofia Quaglia Rescuers struggle to track what happens to animals once they leave their care Read more In Depth  |  Artificial Intelligence China’s GeoGPT led to firing of top European geoscientist By Paul Voosen Fears of AI and foreign influence prompt panic among publishers Read more In Depth  |  U.S. Policy Supreme Court ruling threatens role of science in regulation By Jeffrey Mervis End of Chevron doctrine has far-reaching implications Read more In Depth  |  Reproductive Biology Durable proteins appear to protect ovaries By Mitch Leslie Studies find long-lived proteins are prevalent in the organs Read more Feature There will be blood By Andrew Zaleski Is mimicking the cells that carry hemoglobin the key to a blood substitute? Read more Insights Perspective  |  Immunotherapy Lymphocytes as a living drug for cancer By Steven A. Rosenberg Using a patient’s lymphocytes is approved to treat melanoma and has wider applications Read more Perspective  |  Medicine Developing a pill to treat sickle cell disease By Douglas Higgs, Mira Kassouf A newly identified epigenetic modifier increases fetal hemoglobin in preclinical studies Read more Perspective  |  Neuroscience A new path to migraine By Andrew F. Russo, Jeffrey J. Iliff Cerebrospinal fluid influx directly activates trigeminal neurons in a migraine model Read more Perspective  |  Materials Science DNA and gelatin—a cool aerogel mix By Changyu Shen, Xianhu Liu A degradable biopolymer is an effective radiative cooling material Read more Policy Forum  |  Policy Forum Can federal grid reforms solve the interconnection problem? By Les Armstrong, Alexa Canaan, et al. Coordinated, comprehensive planning is sorely needed Read more Books et al.  |  Science Lives Just keep swimming By Vijaysree Venkatraman A shark scientist charts her own course Read more Books et al.  |  Artificial Intelligence Beyond the looking glass By Michael Spezio An ethicist advocates a moral framework for technology Read more Letter  |  NextGen Voices Preventing bad behavior in academia By Rayane da Cruz Albino, Mark Allen Brimble, et al. Read more Research Research Highlights In Science Journals By Courtney Malo, Michael A. Funk, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Keith T. Smith, Di Jiang, et al. Editors’ selections from the current scientific literature Read more Research Article  |  IMMUNOLOGY An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases By Akiko Oguchi, Akari Suzuki, et al. Read more Research Article  |  CLINICAL MICROBIOLOGY Evolution and host-specific adaptation of Pseudomonas aeruginosa By Aaron Weimann, Adam M. Dinan, et al. Read more Research Article  |  IMMUNOMETABOLISM A metabolic dependency of EBV can be targeted to hinder B cell transformation By Bojana Müller-Durovic, Jessica Jäger, et al. Read more Research Article  |  RICE GENETICS Genomic investigation of 18,421 lines reveals the genetic architecture of rice By Xin Wei, Mengjiao Chen, et al. Read more Research Article  |  PROTEIN ENGINEERING Unsupervised evolution of protein and antibody complexes with a structure-informed language model By Varun R. Shanker, Theodora U. J. Bruun, et al. Read more Research Article  |  FERROELECTRICS Ultrafast high-endurance memory based on sliding ferroelectrics By Kenji Yasuda, Evan Zalys-Geller, et al. Read more Research Article  |  FERROELECTRICS Developing fatigue-resistant ferroelectrics using interlayer sliding switching By Renji Bian, Ri He, et al. Read more Research Article  |  NANOMATERIALS Ultrastrong MXene film induced by sequential bridging with liquid metal By Wei Li, Tianzhu Zhou, et al. Read more Research Article  |  RADIATIVE COOLING A photoluminescent hydrogen-bonded biomass aerogel for sustainable radiative cooling By Jian-Wen Ma, Fu-Rong Zeng, et al. Read more Research Article  |  PLANT ECOLOGY Trees have overlapping potential niches that extend beyond their realized niches By Daniel C. Laughlin, Brian J. McGill Read more Research Article  |  MIGRAINE Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model By Martin Kaag Rasmussen, Kjeld Møllgård, et al. Read more Research Article  |  2D MATERIALS Wigner molecular crystals from multielectron moiré artificial atoms By Hongyuan Li, Ziyu Xiang, et al. Read more Research Article  |  DRUG DEVELOPMENT A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction By Pamela Y. Ting, Sneha Borikar, et al. Read more Research Article  |  NANOMATERIALS Interfacial epitaxy of multilayer rhombohedral transition-metal dichalcogenide single crystals By Biao Qin, Chaojie Ma, et al. Read more Research Article  |  PHAGE COMPETITION An intron endonuclease facilitates interference competition between coinfecting viruses By Erica A. Birkholz, Chase J. Morgan, et al. Read more Careers Working Life Lessons from failure By Shreya Pramanik Read more Essay Essay  |  Microbiome Blockbuster T cells in the gut: A high-resolution view of immune modulation by the gut microbiome is presented By Kazuki Nagashima A high-resolution view of immune modulation by the gut microbiome is presented Read more Essay  |  Microbiome Breaking boundaries: Bacteria act as architects of host T cell modulators using bile acids By Lina Yao Bacteria act as architects of host T cell modulators using bile acids Read more Essay  |  Microbiome Exposed wires: A microbial metabolite influences myelination in the brain By Brittany Needham A microbial metabolite influences myelination in the brain Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. 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