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Brought to you by BioInnovation Institute & Science Prize for Innovation VOLUME 385 | ISSUE 6708 | 2 AUG 2024 Editorial Editorial Cell and gene therapy accessibility By Rayne H. Rouce, Matthew H. Porteus Read more News In Brief News at a glance Read more In Depth  |  Infectious Diseases Landmark trial may herald new era in HIV prevention By Kai Kupferschmidt Twice-yearly lenacapavir injections provide 100% protection in study in African women Read more In Depth  |  Biomedicine Hunt for infectious causes of Alzheimer’s gains momentum By Jennifer Couzin-Frankel New efforts seek causal links between pathogens and dementia Read more In Depth  |  Biomedicine Is it the humidity, or just the heat? By Meredith Wadman Scientists debate the role of humidity in rising heat deaths Read more In Depth  |  Research Policy Study on braiding Indigenous and Western science halted By Jeffrey Mervis, Rodrigo Pérez Ortega After dispute over “coproduction,” U.S. National Academies takes unprecedented step of stopping $2 million study Read more In Depth  |  Mathematics Proof steps toward hidden structure of prime numbers By Zack Savitsky Researchers create fresh tools to attack famed Riemann hypothesis, math’s biggest unsolved problem Read more In Depth  |  Conservation European deforestation rules are flawed, scientists argue By Dyna Rochmyaningsih European Union faces calls to delay commodity import rules aimed at protecting forests Read more Feature Open for business By Jeffrey Brainard Authors are increasingly paying to publish their papers open access. But is it fair or sustainable? Read more Insights Expert Voices CARE-ing for Indigenous nonhuman genomic data — rethinking our approach By Tahu Kukutai, Amanda Black Read more Perspective  |  Genomics Lessons from ancient pathogens By Molly K. Zuckerman, Courtney A. Hofman Ancient infectious diseases and microbes can be used to address contemporary disease Read more Perspective  |  Calorics Sizing up caloric devices By Suxin Qian, Ichiro Takeuchi Emerging solid-state cooling technologies may help reduce overall carbon emissions Read more Perspective  |  Evolutionary Biology A sharp discovery By Elizabeth A. Kellogg Plant prickles are controlled by genes involved in the final step of cytokinin biosynthesis Read more Perspective  |  Neuroimmunology Mapping gut feelings and immune control By Nathalie Vergnolle A chemogenetic screen reveals links between nociceptors and gut immune function Read more Policy Forum  |  Sustainability Mainstreaming nature in US federal policy By Heather Tallis, Eli P. Fenichel, et al. Integrated policy changes must be cross-sectoral, appropriate, strategic, and evidence-based Read more Books et al.  |  Ethics Valuing animal lives By Barbara J. King A journalist advocates “informed coexistence” for human and animal flourishing Read more Books et al.  |  Measurement Standardizing sea level By Samantha Muka A historian traces the complex origins of a seemingly straightforward metric Read more Letter Safeguard stewards of biodiversity knowledge By Carolina Levis, Natalia Hanazaki, et al. Read more Letter Mexico must save the vaquita from gill nets By Lorenzo Rojas-Bracho, Barbara L. Taylor, et al. Read more Letter  |  Outside the Tower Voting for ecological protection By Maya Mayrose Read more Letter Safeguard stewards of biodiversity knowledge—Response By S. Pironon, I. Ondo, et al. Read more Research Research Highlights In Science Journals By Marc S. Lavine, Di Jiang, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Bianca Lopez, Priscilla N. Kelly, et al. Editors’ selections from the current scientific literature Read more Review  |  CONSERVATION Ecological roles and importance of sharks in the Anthropocene Ocean By Simon Dedman, Jerry H. Moxley, et al. Read more Research Article  |  NEUROIMMUNOLOGY A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut By Yangyang Zhu, Kimberly A. Meerschaert, et al. Read more Research Article  |  MOLECULAR BIOLOGY Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis By Zuanning Yuan, Roxana Georgescu, et al. Read more Research Article  |  NEURODEGENERATION Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming By Zhao Sun, Ji-Sun Kwon, et al. Read more Research Article  |  PLANT GENETICS Convergent evolution of plant prickles by repeated gene co-option over deep time By James W. Satterlee, David Alonso, et al. Read more Research Article  |  TROPICAL GLACIERS Recent tropical Andean glacier retreat is unprecedented in the Holocene By Andrew L. Gorin, Jeremy D. Shakun, et al. Read more Research Article  |  CRYSTALLOGRAPHY PhAI: A deep-learning approach to solve the crystallographic phase problem By Anders S. Larsen, Toms Rekis, et al. Read more Research Article  |  PALEONTOLOGY A Cambrian spiny stem mollusk and the deep homology of lophotrochozoan scleritomes By Guangxu Zhang, Luke A. Parry, et al. Read more Research Article  |  SOLAR CELLS Enhanced cation interaction in perovskites for efficient tandem solar cells with silicon By Esma Ugur, Ahmed Ali Said, et al. Read more Research Article  |  CRISPR Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases By Peter H. Yoon, Zeyuan Zhang, et al. Read more Research Article  |  MOLECULAR MACHINES A molecular anion pump By Baihao Shao, Heyifei Fu, et al. Read more Research Article  |  ELECTRON MICROSCOPY Event-responsive scanning transmission electron microscopy By Jonathan J. P. Peters, Bryan W. Reed, et al. Read more Research Article  |  SOLAR CELLS Nuclei engineering for even halide distribution in stable perovskite/silicon tandem solar cells By Yihua Chen, Ning Yang, et al. Read more Research Article  |  PALEOCLIMATE Mid-Pleistocene climate transition triggered by Antarctic Ice Sheet growth By Zhisheng An, Weijian Zhou, et al. Read more Research Article  |  3D PRINTING Additive manufacturing of highly entangled polymer networks By Abhishek P. Dhand, Matthew D. Davidson, et al. Read more Errata Erratum for the Report “Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1” by M.-J. Lee et al. Read more Careers Working Life A reluctant chemist By Shalini Gupta Read more Essay Essay  |  Neuromodulation Navigating internal senses: A road map for the vagal interoceptive system By Qiancheng Zhao A road map for the vagal interoceptive system Read more Essay  |  Neuromodulation Advancing cardiovascular neuromodulation: Aortic baroreceptor afferents act as targets for blood pressure control in hypertension By Ibrahim M. Salman Aortic baroreceptor afferents act as targets for blood pressure control in hypertension Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. 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