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Brought to you by Chen Institute and Science Prize for AI Accelerated Research VOLUME 385 | ISSUE 6715 | 20 SEP 2024 Special Issue Introduction to Special Issue Our perennial rodent companions By Caroline Ash, Bianca Lopez, et al. Read more Policy Forum  |  Animal Research Who cares about lab rodents? By Gail Davies, Robert G. W. Kirk, et al. Humanities and social sciences help advance “cultures of care” around laboratory animal science and welfare Read more Special Issue Review The evolutionary history of wild and domestic brown rats (Rattus norvegicus) By Jason Munshi-South, Joseph A. Garcia, et al. Read more Special Issue Review The complex affective and cognitive capacities of rats By Inbal Ben-Ami Bartal Read more Special Issue Review Emerging patterns in rodent-borne zoonotic diseases By Felicia Keesing, Richard S. Ostfeld Read more Special Issue News  |  Rats The global war on island rats By Elizabeth Pennisi Invasive rodents wreak havoc on island wildlife. How we learned to fight back Read more Books et al.  |  Animal Biology The rat’s tale By Christos Lynteris A charming rodent romp misses some of the creature’s most interesting and unsettling history Read more Books et al.  |  Sociology Model citizens By Ian J. Davidson John Calhoun’s rodent “universes” informed ideas about 20th-century urban life Read more Editorial Editorial Psychedelic research at a crossroads By Stacey B. Armstrong, Alan K. Davis Read more News In Brief News at a glance Read more In Depth  |  Deep-Sea Mining Claim of seafloor ‘dark oxygen’ faces doubts By Paul Voosen Mining companies and others skeptical that metallic nodules electrically split seawater Read more In Depth  |  Science Policy Bill targeting Chinese firms worries U.S. researchers By Robert F. Service Biosecure Act could hinder science collaborations, limit sequencer purchases Read more In Depth  |  Food Science Pediatrics academy faces pushback on GMO advice By Meredith Wadman “Fearmongering” guidelines ignore wealth of scientific evidence, critics say Read more In Depth  |  Research Policy NIH ends funding for key parasitology database By Meredith Wadman Trove of data-mining resources on malaria and other killers will need donations to stay alive Read more In Depth  |  Research Integrity U.S. agency drops controversial changes to misconduct rules By Jeffrey Mervis In first regulatory overhaul in 20 years, Office of Research Integrity takes modest steps toward greater transparency Read more Feature Ice skater By Robin George Andrews Beneath Europa’s icy crust is a salty ocean, perhaps the best place in the Solar System to look for life. A NASA spacecraft will soon set off to probe the jovian moon Read more Insights Expert Voices The coming microbial crisis: Our antibiotic bubble is about to burst By Andreas J. Bäumler Read more Perspective  |  Cancer KRAS takes the road to destruction By Adrienne D. Cox, Channing J. Der A single small molecule degrades numerous KRAS variants involved in cancer Read more Perspective  |  Astrophysics Pushing the boundaries of gravitational wave detection By Yoichi Aso Broadband reduction of quantum noise should accelerate discovery Read more Perspective  |  Climatology Hot and cold Earth through time By Benjamin J. W. Mills Reconstructing ancient Earth’s temperature reveals a global climate regulation system Read more Perspective  |  Neurodegeneration The prion principle and Alzheimer’s disease By Lary C. Walker, Mathias Jucker Similarities to molecular mechanisms underlying prion diseases may help to refine Alzheimer’s disease therapies Read more Perspective  |  Retrospective John I. Brauman (1937–2024) By Richard N. Zare Groundbreaking physical organic chemist Read more Letter Early education’s long-term benefits By Jorge Luis García Read more Letter Early education’s long-term benefits—Response By Margaret Burchinal, Tyler Watts, et al. Read more Letter Pakistan’s fencing threatens conservation By Ghulam Nabi, Tariq Aziz Read more Research Research Highlights In Science Journals By Corinne Simonti, Jake S. Yeston, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Caroline Ash, Ankit Walia, et al. Editors’ selections from the current scientific literature Read more Research Article  |  IMMUNOLOGY Germline mutations in a G protein identify signaling cross-talk in T cells By Hyoungjun Ham, Huie Jing, et al. Read more Research Article  |  HUBBARD MODEL Origin and fate of the pseudogap in the doped Hubbard model By Fedor Šimkovic, Riccardo Rossi, et al. Read more Research Article  |  PALEOCLIMATE A 485-million-year history of Earth’s surface temperature By Emily J. Judd, Jessica E. Tierney, et al. Read more Research Article  |  DRUG DISCOVERY Large library docking identifies positive allosteric modulators of the calcium-sensing receptor By Fangyu Liu, Cheng-Guo Wu, et al. Read more Research Article  |  QUANTUM OPTICS Squeezing the quantum noise of a gravitational-wave detector below the standard quantum limit By Wenxuan Jia, Victoria Xu, et al. Read more Research Article  |  POLYMER CHEMISTRY Polyolefin waste to light olefins with ethylene and base-metal heterogeneous catalysts By Richard J. Conk, Jules F. Stahler, et al. Read more Research Article  |  QUANTUM COMPUTING High-fidelity teleportation of a logical qubit using transversal gates and lattice surgery By C. Ryan-Anderson, N. C. Brown, et al. Read more Research Article  |  ORGANIC CHEMISTRY A decarbonylative approach to alkylnickel intermediates and C(sp3)-C(sp3) bond formation By Zhidao Huang, Michelle E. Akana, et al. Read more Research Article  |  DRUG DEVELOPMENT Targeting cancer with small-molecule pan-KRAS degraders By Johannes Popow, William Farnaby, et al. Read more Research Article  |  LIZARD GENETICS MAYEX is an old long noncoding RNA recruited for X chromosome dosage compensation in a reptile By Mariela Tenorio, Samantha Cruz-Ruiz, et al. Read more Research Article  |  CLICK CHEMISTRY Radical-mediated click-clip reactions By Jiantao Zhao, Huacheng Yu, et al. Read more Research Article  |  GLACIOLOGY Atmospheric blocking slows ocean-driven melting of Greenland’s largest glacier tongue By Rebecca Adam McPherson, Claudia Wekerle, et al. Read more Research Article  |  SYNTHETIC BIOLOGY Artificial kinetochore beads establish a biorientation-like state in the spindle By Kohei Asai, Yuanzhuo Zhou, et al. Read more Careers Working Life Savoring the sandwich By Kyle G. Ratner Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. Sign up Journals Science Science Advances Science Immunology Science Robotics Science Signaling Science Translational Medicine Useful links News Careers Commentary Podcast Webinars Prizes and Awards Help Access & Subscriptions Reprints & Permissions Contact Us Follow us

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