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Brought to you by New England Biolabs VOLUME 386 | ISSUE 6720 | 25 OCT 2024 Editorial Editorial Move past promises for biodiversity By Rodrigo A. Medellin Read more News In Brief News at a glance Read more In Depth  |  Archaeology Remote highland city upends ideas of urbanism By Andrew Lawler Drones and lidar uncover high-altitude Uzbek site, part of the medieval Silk Road trade Read more In Depth  |  Developmental Biology AI reveals how sperm sticks to egg during fertilization By Catherine Offord Two studies use software developed by some of this year’s Nobel winners to find elusive protein complex Read more In Depth  |  Biomedicine Aging ‘clocks’ battle for science glory and cash By Mitch Leslie Contest aims to improve molecular assays needed to test aging treatments Read more In Depth  |  Ecology ‘Landscape of fear’ had little impact on Yellowstone ecology By Virginia Morell Predation by animals and humans, not behavioral change, was what lightened the impact of elk on young trees Read more In Depth  |  Scientific Community Hurricane-battered researchers assess damage By Christie Wilcox, Phie Jacobs Years of recovery lie ahead for the southeastern United States after Helene and Milton Read more Feature Edit the messenger By Mitch Leslie New treatments aim to counteract mutant genes by fixing the faulty RNA they produce Read more Feature Open with care By Sandeep Ravindran Indigenous researchers and communities are reshaping how Western science thinks about open access to data Read more Insights Expert Voices Dots in a murky sky By Andy Lawrence Read more Perspective  |  Evolution Predicting and anticipating rapid evolution By Patrik Nosil Human impacts alter species interactions and evolutionary dynamics in wild populations Read more Perspective  |  Drug Discovery Impact of CRISPR in cancer drug discovery By Jason Moffat, Alexis C. Komor, et al. Precision gene editing enables massively parallel identification of cancer-promoting genes Read more Perspective  |  Cancer A pro-oxidant suppresses unrelated diseases By Emanuela Pannia, James J. Dowling A lipid kinase inhibitor ameliorates both prostate cancer and a muscle disease in mice Read more Perspective  |  Materials Science Distinct interfacial structures between grains By Jian Luo Adsorption transitions at grain boundaries in a polycrystal result in structures that are forbidden in bulk crystals Read more Policy Forum  |  Biodiversity Achieving “nature positive” requires net gain legislation By Hannah Thomas, Yi Fei Chung, et al. Reforms underway in Australia highlight key challenges Read more Books et al.  |  Language Spreading the word By Andrew Robinson Scholars probe the origins and decipherment of written communication Read more Books et al.  |  Social Science Under the influence By Dov Greenbaum A journalist revisits his popular theory of social contagions Read more Books et al.  |  Podcast Imagination: A Manifesto Read more Letter Colombia acts to combat plastic pollution By Nelson Rangel-Buitrago, Adriana Gracia C. Read more Letter Prevent the spread of Oropouche fever in Brazil By Nathália Mariana Santos Sansone, Luiz Felipe Azevedo Marques, et al. Read more Letter  |  Life in Science Embraced by Norway’s fishing villages By Anna Lena Bercht Read more Research Research Highlights In Science Journals By Sacha Vignieri, Phil Szuromi, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Madeleine Seale, Sacha Vignieri, et al. Editors’ selections from the current scientific literature Read more Review  |  MICROPLASTICS Twenty years of microplastic pollution research—what have we learned? By Richard C. Thompson, Winnie Courtene-Jones, et al. Read more Research Article  |  REPRODUCTION The landscape of RNA binding proteins in mammalian spermatogenesis By Yang Li, Yuanyuan Wang, et al. Read more Research Article  |  METABOLISM Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function By Manojit M. Swamynathan, Shan Kuang, et al. Read more Research Article  |  MOLECULAR BIOLOGY Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade By Lei Li, 李磊, et al. Read more Research Article  |  IMMUNOLOGY Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis By Matthew D. Park, Jessica Le Berichel, et al. Read more Research Article  |  MICROBIOTA A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase By Jiye Cheng, Siddarth Venkatesh, et al. Read more Research Article  |  NANOMATERIALS Reductive pathways in molten inorganic salts enable colloidal synthesis of III-V semiconductor nanocrystals By Justin C. Ondry, Zirui Zhou, et al. Read more Research Article  |  ELECTROCHEMISTRY Unification of insertion and supercapacitive storage concepts: Storage profiles in titania By Chuanlian Xiao, Hongguang Wang, et al. Read more Research Article  |  MICROBIOLOGY A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont By Madeline L. Sheahan, Katia Flores, et al. Read more Research Article  |  METALLURGY Topological grain boundary segregation transitions By Vivek Devulapalli, Enze Chen, et al. Read more Research Article  |  WILDFIRES The fastest-growing and most destructive fires in the US (2001 to 2020) By Jennifer K. Balch, Virginia Iglesias, et al. Read more Research Article  |  HYDROGELS Soft hydrogel semiconductors with augmented biointeractive functions By Yahao Dai, Shinya Wai, et al. Read more Research Article  |  PROTEIN DESIGN Scalable protein design using optimization in a relaxed sequence space By Christopher Frank, Ali Khoshouei, et al. Read more Research Article  |  AGROCHEMICAL EFFECTS Pervasive sublethal effects of agrochemicals on insects at environmentally relevant concentrations By Lautaro Gandara, Richard Jacoby, et al. Read more Research Article  |  INDUCED EVOLUTION Human-driven evolution of color in a stonefly mimic By Steven Ni, Graham A. McCulloch, et al. Read more Careers Working Life Wall of fame By Yutan Getzler Read more Association Affairs Association Affairs Group Releases Report on STEMM Workforce Barriers Inaugural Multidisciplinary Working Group drew upon expertise of AAAS volunt Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. Sign up Journals Science Science Advances Science Immunology Science Robotics Science Signaling Science Translational Medicine Useful links News Careers Commentary Podcast Webinars Prizes and Awards Help Access & Subscriptions Reprints & Permissions Contact Us Follow us

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