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Brought to you by Chen Institute and Science Prize for AI Accelerated Research VOLUME 386 | ISSUE 6723 | 15 NOV 2024 Editorial Editorial Science is neither red nor blue By Marcia McNutt Read more Editorial Time to take stock By H. Holden Thorp Read more News In Brief News at a glance Read more In Depth  |  U.S. Election Research advocates see ‘no good news for science’ By Jeffrey Mervis Trump agenda and a Republican Congress point to funding cuts and policy shifts Read more In Depth  |  U.S. Election Trump won. Is NIH in for a major shake-up? By Jocelyn Kaiser Congress might serve as a bulwark, but some changes may be coming Read more In Depth  |  U.S. Election ‘America first’ could affect health worldwide By Gretchen Vogel Scientists worry Donald Trump will leave WHO again and slash disease control programs Read more In Depth  |  Oceanography Famed flipping ship gets second shot at research By Sean Cummings Saved from the scrapyard, unique ocean platform to be revamped before redeployment Read more In Depth  |  Biomedicine Preprint on Alzheimer’s drug deaths ignites author dispute By Jennifer Couzin-Frankel Co-authors say preliminary data on lecanemab fatalities don’t support the paper’s claims Read more In Depth  |  Research Infrastructure Russia postpones three scientific ‘megaprojects’ By Eugene Gerden Economic sanctions, budget woes hamper progress on x-ray sources and neutron beams Read more Feature The counterattack By Jennifer Couzin-Frankel An immune cell treatment that fights cancer is now taking aim at autoimmune disease Read more Insights Expert Voices The metaphors of artificial intelligence By Melanie Mitchell Read more Perspective  |  Gas Separation Heat up to catch carbon By He Li, Dan Zhao A metal-organic framework is activated to capture carbon dioxide at high temperatures Read more Perspective  |  Quantum Computing The journey to a mechanical qubit By Fabio Pistolesi An acoustic resonator can be directly manipulated to store quantum information Read more Perspective  |  Synthetic Biology Learning the language of DNA By Christina V. Theodoris A genomic foundation model broadly enables sequence modeling, prediction, and design Read more Perspective  |  Biology The disciplinary matrix of holobiont biology By Seth R. Bordenstein, The Holobiont Biology Network Uniting life’s seen and unseen realms guides a conceptual advance in research Read more Policy Forum  |  Regulatory Science Advancing alternative methods to reduce animal testing By Chad P. Nelson, Paul Brown, et al. Emerging approaches show promise for regulatory use Read more Books et al.  |  Ecology Tomorrow’s trees By Sarah Boon An ecologist probes the future of forests Read more Books et al.  |  Natural History A voyage to victory By Angela Chuang, Orlando Schwery Players help Darwin discover new species and develop scientific theories in a fast-paced board game Read more Letter Argentina’s unsustainable policies By Sofia Capasso, Verónica Capasso Read more Letter End illegal sand mining in China By Mingrong Liang, Yuling Liang, et al. Read more Letter Plastics treaty: Address building materials By Bethanie Carney Almroth, Veena Singla Read more Research Research Highlights In Science Journals By Bianca Lopez, Keith T. Smith, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Peter Stern, Madeleine Seale, et al. Editors’ selections from the current scientific literature Read more Review  |  MICROBIOTA Chemical genetic approaches to dissect microbiota mechanisms in health and disease By Xinglin Yang, Howard C. Hang Read more Research Article  |  METABOLISM A glutamine metabolic switch supports erythropoiesis By Junhua Lyu, Zhimin Gu, et al. Read more Research Article  |  PLANT SCIENCE SPL13 controls a root apical meristem phase change by triggering oriented cell divisions By Baojun Yang, Yanbiao Sun, et al. Read more Research Article  |  GENERATIVE GENOMICS Sequence modeling and design from molecular to genome scale with Evo By Eric Nguyen, Michael Poli, et al. Read more Research Article  |  STRUCTURAL BIOLOGY Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1 By Yi Lu, Chen-Xi Yue, et al. Read more Research Article  |  GROUNDWATER Predictions of groundwater PFAS occurrence at drinking water supply depths in the United States By Andrea K. Tokranov, Katherine M. Ransom, et al. Read more Research Article  |  CLOUDS Glaciation of liquid clouds, snowfall, and reduced cloud cover at industrial aerosol hot spots By Velle Toll, Jorma Rahu, et al. Read more Research Article  |  GENE THERAPY Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies By Sean R. Lindley, Kadiam C. Venkata Subbaiah, et al. Read more Research Article  |  CELL BIOLOGY Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy By Cristian Prieto-Garcia, Vigor Matkovic, et al. Read more Research Article  |  ORGANIC CHEMISTRY Synchronous recognition of amines in oxidative carbonylation toward unsymmetrical ureas By Jinhui Wang, Shengchun Wang, et al. Read more Research Article  |  QUANTUM SYSTEMS A mechanical qubit By Yu Yang, Igor Kladarić, et al. Read more Research Article  |  RADIATIVE COOLING Subambient daytime radiative cooling of vertical surfaces By Fei Xie, Weiliang Jin, et al. Read more Research Article  |  RESTORATION ECOLOGY Diverse and larger tree islands promote native tree diversity in oil palm landscapes By Gustavo B. Paterno, Fabian Brambach, et al. Read more Research Article  |  PSYCHEDELICS Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states By J. Muir, S. Lin, et al. Read more Research Article  |  ASTROCHEMISTRY Detection of interstellar 1-cyanopyrene: A four-ring polycyclic aromatic hydrocarbon By Gabi Wenzel, Ilsa R. Cooke, et al. Read more Research Article  |  GREENHOUSE GASES High-temperature carbon dioxide capture in a porous material with terminal zinc hydride sites By Rachel C. Rohde, Kurtis M. Carsch, et al. Read more Careers Working Life Truly listening By Sukrut C. Kamerkar Read more Essay Essay  |  Cell & Molecular Biology Gatekeepers of the brain: Identifying hidden mechanisms of type A GABA receptor signaling and assembly By Andrija Sente Identifying hidden mechanisms of type A GABA receptor signaling and assembly Read more Essay  |  Ecology & Environment Digging below the surface: Hidden risks for ground-nesting bees By Sabrina Rondeau Hidden risks for ground-nesting bees Read more Essay  |  Genomics, Proteomics, and Systems Biology How to build a human: Piecing together the body’s cellular puzzle By Jarrod Shilts Piecing together the body’s cellular puzzle Read more Essay  |  Molecular Medicine To target, to escape, perchance to cure: Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies By Gabriele Casirati Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. 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