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Brought to you by CancerTools.org VOLUME 386 | ISSUE 6726 | 6 DEC 2024 Editorial Editorial Science and America’s challenge By Heather Wilson Read more News In Brief News at a glance Read more In Depth  |  Biomedicine Trump picks an ‘outsider’ and NIH critic to lead agency By Jocelyn Kaiser Jay Bhattacharya, who has analyzed NIH funding and ripped U.S. COVID-19 policies, could overhaul key funder Read more In Depth Storm warnings for FDA and CDC By Jennifer Couzin-Frankel, Phie Jacobs Read more In Depth  |  Artificial Intelligence ‘Brutal’ math test raises the bar for AI By Zack Savitsky Model-stumping benchmark shows human experts remain on top—for now Read more In Depth  |  Volcanology Beneath Antarctica’s ice, a fiery future may await By Paul Voosen Researchers probe volcanoes’ response to a changing world Read more In Depth  |  Neuroscience Controversial study redraws classical picture of the neuron By Sofia Quaglia Fine-grained imaging of mouse brain cells suggests “pearling” of axons that may help with signaling Read more In Depth  |  Infectious Disease War-torn Ukraine is breeding drug-resistant bacterial strains By Richard Stone Urgent action underway to bolster treatments and prevent dangerous microbes from spilling across borders Read more Feature Breaking the glass By Sofia Moutinho Latin America is a leader in nonprofit open-access journals. But it struggles to give them global visibility Read more Insights Perspective  |  Developmental Biology How the brain hatches an escape By Francesco Argenton, Yoav Gothilf A neuroendocrine circuit controls when fish larvae are ready to hatch Read more Perspective  |  Microbiology Home sweet home By T. Jarrod Smith, Karen Guillemin Sugar-binding adhesins enable bacteria to persist in specific host niches Read more Perspective  |  Biosensors Continuous monitoring with a shake By Sihong Wang Oscillating signals rapidly reset a sensor for real-time protein detection in the body Read more Perspective  |  Synthetic Biology Synthetic gene circuits drive disease-fighting T cells By Marco L. Davila, Renier Brentjens Immune cells can be programmed to deliver targeted therapies in models of brain and inflammatory disease Read more Policy Forum  |  Human Subjects Protections Act on a mandate to protect research subjects’ privacy By Leslie E. Wolf, Natalie Ram Congress called for the protection of data from legal process Read more Books et al.  |  Classics Revisited On the origins of organisms By Antonio Lazcano The heterotrophic theory of the origin of life turns 100 Read more Books et al.  |  Science and Society Scopes monkey trial, in context By Vassiliki Betty Smocovitis A writer reexamines the 20th-century showdown between science and religion Read more Letter Extending prosperity to Mexican seas By Octavio Aburto-Oropeza, Catalina López-Sagástegui, et al. Read more Letter EU needs groundwater ecosystems guidelines By Tiziana Di Lorenzo, Enrico Lunghi, et al. Read more Research Research Highlights In Science Journals By Corinne Simonti, Caroline Ash, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Marc S. Lavine, Corinne Simonti, et al. Editors’ selections from the current scientific literature Read more Review  |  CELL BIOLOGY Imperfect wound healing sets the stage for chronic diseases By Paul Martin, Carlos Pardo-Pastor, et al. Read more Research Article  |  CELL ENGINEERING Programming tissue-sensing T cells that deliver therapies to the brain By Milos S. Simic, Payal B. Watchmaker, et al. Read more Research Article  |  CELL ENGINEERING Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs By Nishith R. Reddy, Hasna Maachi, et al. Read more Research Article  |  MARINE CONSERVATION Ecological erosion and expanding extinction risk of sharks and rays By Nicholas K. Dulvy, Nathan Pacoureau, et al. Read more Research Article  |  SPECTROSCOPY Dissecting the hydrogen bond network of water: Charge transfer and nuclear quantum effects By Mischa Flór, David M. Wilkins, et al. Read more Research Article  |  THERMOELECTRICS Room-temperature exceptional plasticity in defective Bi2Te3-based bulk thermoelectric crystals By Tingting Deng, Zhiqiang Gao, et al. Read more Research Article  |  MICROBIOME A conserved bacterial genetic basis for commensal-host specificity By Karina Gutiérrez-García, Kevin Aumiller, et al. Read more Research Article  |  CLIMATE CHANGE Climate change extinctions By Mark C. Urban Read more Research Article  |  INFLUENZA A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors By Ting-Hui Lin, Xueyong Zhu, et al. Read more Research Article  |  PIGMENTATION A microRNA is the effector gene of a classic evolutionary hotspot locus By Shen Tian, Yoshimasa Asano, et al. Read more Research Article  |  MOUSE T2T The complete telomere-to-telomere sequence of a mouse genome By Junli Liu, Qilin Li, et al. Read more Research Article  |  BIOSENSORS Active-reset protein sensors enable continuous in vivo monitoring of inflammation By H. Zargartalebi, S. Mirzaie, et al. Read more Research Article  |  PROTEIN DESIGN Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists By Matthias Glögl, Aditya Krishnakumar, et al. Read more Research Article  |  LIQUID CRYSTALS Programming liquid crystal elastomers for multistep ambidirectional deformability By Yuxing Yao, Atalaya Milan Wilborn, et al. Read more Research Article  |  PLASTIC POLLUTION Pathways to reduce global plastic waste mismanagement and greenhouse gas emissions by 2050 By A. Samuel Pottinger, Roland Geyer, et al. Read more Research Article  |  DEVELOPMENT A transient neurohormonal circuit controls hatching in fish By Deodatta S. Gajbhiye, Genevieve L. Fernandes, et al. Read more Errata Erratum for the Research Article “APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016” by Á. O’Toole et al. Read more Errata Erratum for the Research Article “How do social media feed algorithms affect attitudes and behavior in an election campaign?” by A. M. Guess et al. Read more Expression of Concern Editorial Expression of Concern By H. Holden Thorp Read more Expression of Concern Editorial Expression of Concern By H. Holden Thorp Read more Careers Working Life Speaking for myself By Ogochukwu Joseph Uweru Read more New Products New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers. 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