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Brought to you by New England Biolabs  VOLUME 386 | ISSUE 6727 | 13 DEC 2024 Special Issue Special Issue News  |  2024 Breakthrough of the Year The long shot By Jon Cohen An injectable HIV drug with a novel mechanism shows remarkable ability to prevent infection Read more Special Issue News  |  2024 Breakthrough of the Year Runners-up By Paul Voosen, Elizabeth Pennisi, et al. Read more Special Issue News  |  2024 Breakthrough of the Year Breakdowns of the year By Martin Enserink, David Malakoff, et al. What went wrong in the world of science Read more Editorial Editorial The great work continues By H. Holden Thorp Read more News In Brief News at a glance Read more In Depth  |  Biomedicine Trump 2.0 could mean big cuts for animal research By David Grimm Groups targeting animal studies see an opening Read more In Depth  |  Seafloor Geology China’s ‘dreamy’ scientific drilling ship takes global command By Dennis Normile As U.S. leadership falters, Meng Xiang prepares for bold mission to retrieve rocks from Earth’s mantle Read more In Depth With venerable ship’s retirement, U.S.-led ocean-drilling program ends By Paul Voosen Read more In Depth  |  Physics Google takes key step toward an error-free quantum computer By Adrian Cho Quantum bits’ delicate states preserved by expanding them Read more In Depth  |  Biomedicine Why hasn’t the bird flu pandemic started? By Kai Kupferschmidt Mutations found in H5N1 viruses portend major outbreak soon, some scientists fear Read more In Depth  |  Science Funding Research cuts in New Zealand target social sciences By Veronika Meduna Basic research loses out as the country’s “blue-sky” fund shifts to research focused on helping economy Read more In Depth  |  Paleoanthropology Study reveals kinship among first modern humans in Europe By Andrew Curry Ancient DNA links people across hundreds of kilometers Read more Insights Expert Voices In good hands: A case for improving robotic dexterity By Aude G. Billard Read more Perspective  |  Geophysics Transforming coastal mapping from space By Cheinway Hwang, Daocheng Yu A recent altimeter mission resolves fine seafloor signatures and coastal geospatial information Read more Perspective  |  Neuroscience A neuronal gene that loops the loop By Kyle S. Czarnecki, Elizabeth A. Heller Noncoding RNA controls the expression of a gene implicated in drug- and stress-induced behaviors Read more Perspective  |  Synthetic Biology Bringing neural networks to life By Katie Galloway, Christopher Johnstone A synthetic protein-based winner-take-all neural network controls cell fate decisions Read more Perspective  |  Photonics Optical devices as thin as atoms By Melissa Li, Qitong Li, et al. Controlling exciton resonances in twodimensional materials can create dynamic flat optics Read more Policy Forum  |  Conservation Indigenizing conservation science for a sustainable Amazon By Carolina Levis, Justino Sarmento Rezende, et al. Dialogues between Western and Indigenous systems are critical Read more Books et al.  |  Review RoundUp The two cultures meet again By Anne Milasincic Andrews, Jon Christensen, et al. Read more Letter Flawed restoration plans on Tibetan plateau By Yujie Niu, Johannes M. H. Knops, et al. Read more Letter Curbing household medication waste By Ruolin Hou, Xin Liu, et al. Read more Letter El Salvador’s misguided land use guidelines By Silvio J. Crespin, Francisco S. Álvarez, et al. Read more Research Research Highlights In Science Journals By Caroline Ash, Sacha Vignieri, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Caroline Ash, Ian S. Osborne, et al. Editors’ selections from the current scientific literature Read more Review  |  DEVICE TECHNOLOGY Addressing interconnect challenges for enhanced computing performance By Joon-Seok Kim, Joonyun Kim, et al. Read more Research Article  |  NATURAL PRODUCTS Autologous DNA mobilization and multiplication expedite natural products discovery from bacteria By Feng Xie, Haowen Zhao, et al. Read more Research Article  |  SEXUAL SELECTION Sexual selection promotes reproductive isolation in barn swallows By Drew R. Schield, Javan K. Carter, et al. Read more Research Article  |  LUNG DAMAGE REPAIR An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung By Dakota L. Jones, Michael P. Morley, et al. Read more Research Article  |  HOMININ GENETICS Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans By Leonardo N. M. Iasi, Manjusha Chintalapati, et al. Read more Research Article  |  SYSTEMS BIOLOGY A synthetic protein-level neural network in mammalian cells By Zibo Chen, James M. Linton, et al. Read more Research Article  |  GEOPHYSICS Abyssal marine tectonics from the SWOT mission By Yao Yu, David T. Sandwell, et al. Read more Research Article  |  SOLAR CELLS Inverse design workflow discovers hole-transport materials tailored for perovskite solar cells By Jianchang Wu, Luca Torresi, et al. Read more Research Article  |  THERMOELECTRICS Nanobinders advance screen-printed flexible thermoelectrics By Wenyi Chen, Xiao-Lei Shi, et al. Read more Research Article  |  MARINE HEATWAVES Catastrophic and persistent loss of common murres after a marine heatwave By Heather M. Renner, John F. Piatt, et al. Read more Research Article  |  FISHERIES Evidence of spillover benefits from large-scale marine protected areas to purse seine fisheries By John Lynham, Juan Carlos Villaseñor-Derbez Read more Research Article  |  CELLULAR NEUROSCIENCE A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation By Rose Marie Akiki, Rebecca G. Cornbrooks, et al. Read more Research Article  |  CORAL SURVIVAL Natural selection could determine whether Acropora corals persist under expected climate change By Liam Lachs, Yves-Marie Bozec, et al. Read more Research Article  |  ECOLOGY Diverse phage communities are maintained stably on a clonal bacterial host By Nora C. Pyenson, Asher Leeks, et al. Read more Research Article  |  STELLAR PHYSICS Sun-like stars produce superflares roughly once per century By Valeriy Vasilyev, Timo Reinhold, et al. Read more Research Article  |  HYDROLOGY More flow upstream and less flow downstream: The changing form and function of global rivers By Dongmei Feng, Colin J. Gleason Read more Careers Working Life My best shot By Allison Boboltz Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. Sign up Journals Science Science Advances Science Immunology Science Robotics Science Signaling Science Translational Medicine Useful links News Careers Commentary Podcast Webinars Prizes and Awards Help Access & Subscriptions Reprints & Permissions Contact Us Follow us

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