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Brought to you by The Noster & Science Microbiome Prize VOLUME 387 | ISSUE 6734 | 7 FEB 2025 Special Issue Policy Forum  |  The Polar World Arctic research cooperation in a turbulent world By Jennifer Spence, John Holdren, et al. Rapid Arctic change requires multifaceted approaches with Arctic peoples at the forefront Read more Special Issue Review  |  The Polar World Antarctica in 2025: Drivers of deep uncertainty in projected ice loss By Helen Amanda Fricker, Benjamin K. Galton-Fenzi, et al. Read more Special Issue Review  |  The Polar World Advances and shortfalls in knowledge of Antarctic terrestrial and freshwater biodiversity By L. R. Pertierra, P. Convey, et al. Read more Special Issue Review  |  ARCTIC WARMING Disappearing landscapes: The Arctic at +2.7°C global warming By Julienne C. Stroeve, Dirk Notz, et al. Read more Special Issue News  |  The Polar World Inside an ice stream By Paul Voosen Drill cores, fiber sensors, and radars spy on an enigmatic river of ice Read more Introduction to Special Issue  |  The Polar World Extreme Conditions By Jesse Smith, Bianca Lopez, et al. Read more Editorial Editorial Keeping our eye on the ball By Willie E. May Read more Editorial A world less safe and secure By Lawrence O. Gostin, Benjamin Mason Meier Read more News In Brief News at a glance Read more In Depth  |  U.S. Science Policy Trump orders cause chaos at science agencies By Jeffrey Mervis Wild week of canceled meetings, program changes, and data purges creates high anxiety Read more In Depth  |  Geology After abuse, Inuit group closes off ancient rock belt By Rachel Berkowitz The nearly 4-billion-year-old rocks offer a look into Earth’s earliest years Read more In Depth  |  Earth Science New complexity emerges in Earth’s ‘boring’ middle region By Paul Voosen Planetary CT scans and lab experiments reveal layering and intricate flows in the mantle Read more In Depth  |  Infectious Diseases Indonesia’s new capital poses public health risks By Dyna Rochmyaningsih Scientists worry about potential rise in malaria and insect-borne viral diseases Read more In Depth  |  Biomedicine A new ‘mini-CRISPR’ flexes its editing power in monkey muscles By Jennifer Couzin-Frankel The downsized DNA-slicing machinery may reach more tissues to take aim at more diseases Read more Feature In the cradle of cholera By Martin Enserink Bangladesh is leading the fight against this ancient scourge, and vaccine researcher Firdausi Qadri is on the front lines Read more Insights Expert Voices Free speech, fact checking, and the right to accurate information By Stephan Lewandowsky Read more Perspective  |  Materials Science Naturally twisted to sieve stress By Pablo D. Zavattieri Mantis shrimp display phononic behavior similar to that of artificial metamaterials Read more Perspective  |  Synthetic Biology Relating DNA sequence, organization, and function By Geoffrey Fudenberg, Vijay Ramani Cross-species mosaic genomes provide insight into synthetic chromosome design Read more Perspective  |  Evolution Convergent evolution in whale and human vocal cultures By Andrew Whiten, Mason Youngblood The complex songs of humpback whales conform to fundamental laws of language Read more Perspective  |  Malaria Not just monkey business By Robert W. Moon, Ellen S. C. Bushell Functional genomics in malaria unlocks comparative biology across the family tree Read more Books et al.  |  Polar Science Probing the planet’s poles By Sarah Boon A paleontologist explores our intertwined fate with Earth’s most remote regions Read more Books et al.  |  Public Health The future of measles By Arthur Caplan A pediatrician confronts the disease’s persistence in a world where eradication is possible Read more Letter Addressing Australia’s biodiversity crisis By Euan G. Ritchie, Dale G. Nimmo Read more Letter Australia’s inadequate marine protection By Madeline Davey, James E. M. Watson Read more Letter Generative AI exacerbates the climate crisis By Qiong Chen, Jinghui Wang, et al. Read more Research Research Highlights In Science Journals By Ian S. Osborne, Madeleine Seale, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Corinne Simonti, Marc S. Lavine, et al. Editors’ selections from the current scientific literature Read more Research Article  |  IMMUNOMETABOLISM Nutrient-driven histone code determines exhausted CD8+ T cell fates By Shixin Ma, Michael S. Dahabieh, et al. Read more Research Article  |  EPIGENETICS Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus By Léa Meneu, Christophe Chapard, et al. Read more Research Article  |  NEPHROLOGY Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants By Hongbo Liu, Amin Abedini, et al. Read more Research Article  |  MALARIA The essential genome of Plasmodium knowlesi reveals determinants of antimalarial susceptibility By Brendan Elsworth, Sida Ye, et al. Read more Research Article  |  MALARIA Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites By Jenna Oberstaller, Shulin Xu, et al. Read more Research Article  |  EVOLUTION The Silene latifolia genome and its giant Y chromosome By Carol Moraga, Catarina Branco, et al. Read more Research Article  |  EVOLUTION Rapid and dynamic evolution of a giant Y chromosome in Silene latifolia By Takashi Akagi, Naoko Fujita, et al. Read more Research Article  |  TOPOLOGICAL OPTICS Four-dimensional conserved topological charge vectors in plasmonic quasicrystals By Shai Tsesses, Pascal Dreher, et al. Read more Research Article  |  ANIMAL COMMUNICATION Whale song shows language-like statistical structure By Inbal Arnon, Simon Kirby, et al. Read more Research Article  |  SPECTROSCOPY Squeezed dual-comb spectroscopy By Daniel I. Herman, Mathieu Walsh, et al. Read more Research Article  |  BIOMATERIALS Does the mantis shrimp pack a phononic shield? By N. A. Alderete, S. Sandeep, et al. Read more Research Article  |  PLANT SCIENCE Moisture-responsive root-branching pathways identified in diverse maize breeding germplasm By Johannes D. Scharwies, Taylor Clarke, et al. Read more Research Article  |  METABOLISM Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes By Haaglim Cho, Chien-Cheng Lai, et al. Read more Research Article  |  NEUROSCIENCE Overwriting an instinct: Visual cortex instructs learning to suppress fear responses By Sara Mederos, Patty Blakely, et al. Read more Careers Working Life The impostor club By Anas Bedraoui Read more New Products New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers. Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. 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