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Brought to you by New England Biolabs  VOLUME 388 | ISSUE 6742 | 4 APR 2025 Editorial Editorial Don’t quit the long game By Stefan Raff-Heinen, Fiona E. Murray Read more News In Brief News at a glance Read more In Depth  |  Trump Administration Killed NIH grants could waste billions of dollars By Sara Reardon More than $1.4 billion in sunk research costs may produce few results, analysis suggests Read more In Depth  |  Trump Administration NSF has awarded almost 50% fewer grants By Jeffrey Mervis An analysis shows a drastic falloff since Trump took office. The finding conflicts with the director’s claims Read more In Depth  |  Energy Stellarators, once fusion’s dark horse, hit their stride By Daniel Clery Multiple companies aim to build pilot plants using twisted magnets Read more In Depth  |  Infectious Diseases NIH cancels research grants for COVID-19 and future pandemics By Jon Cohen Scientists reject claim that the work is no longer needed Read more In Depth  |  Scientific Community International scientists rethink U.S. conferences By Kate Langin Opposition to Trump administration and fears of customs run-ins are shifting travel plans Read more In Depth  |  Population Genetics Ancient DNA illuminates ‘green Sahara’ dwellers By Andrew Curry Skeletons from an ancient, lush interlude offer genetic peek at a lost population Read more In Depth  |  Animal Behavior ‘Uniquely human’ language capacity found in bonobos By Cathleen O’Grady Study is the first to show an animal combining different calls to make new meanings Read more Feature Failure to communicate By Rebekah White Geoengineering could be crucial in the fight against climate change. But first scientists need to learn how to talk to the public about it Read more Insights Expert Voices Beyond the Binary: Navigating AI’s Uncertain Future in Africa By Rose M. Mutiso Read more Perspective  |  Animal Behavior Saving the cultural legacy of wild animals By Ammie K. Kalan, Lydia V. Luncz Loss of biodiversity threatens the study of tool use and other cultural behaviors in animals Read more Perspective  |  Cell Biology Archaea go multicellular under pressure By Eva K. Pillai, Thibaut Brunet A microbe from the Dead Sea switches to a tissue-like form when compressed Read more Perspective  |  Chemistry Catalysis at the crossroads By Cathy L. Tway, Sorin V. Filip Homogeneous and heterogeneous catalysis work concurrently in a chemical process Read more Perspective  |  Biomedicine Beyond wear and tear at the joint By Chuan-ju Liu Bile acid metabolism meets glucagon-like peptide 1 signaling in osteoarthritis Read more Policy Forum  |  Infectious Disease Rubella and measles: The beginning of the endgame By Matthew J. Ferrari, William J. Moss Benchmarks must be established and progress tracked to set a global target and take action Read more Books et al.  |  Psychology Convince me, control me By Katie Joice A historian probes the origins and evolution of psychological manipulation Read more Books et al.  |  Professional Development When trainees seek other paths By Jonathan Wai A new book offers advice for mentoring those who do not aspire to follow in faculty’s footsteps Read more Letter  |  NextGen Voices Science safeguards By Zhen Wang, Sara Shakir, et al. Read more Research Research Highlights In Science Journals By Sacha Vignieri, Mattia Maroso, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Sacha Vignieri, Jesse Smith, et al. Editors’ selections from the current scientific literature Read more Review  |  INSECT DECLINE Integrating multiple evidence streams to understand insect biodiversity change By Rob Cooke, Charlotte L. Outhwaite, et al. Read more Research Article  |  EVOLUTION A geological timescale for bacterial evolution and oxygen adaptation By Adrián A. Davín, Ben J. Woodcroft, et al. Read more Research Article  |  NEUROSCIENCE Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop By Zepeng Fang, Yuanyuan Dang, et al. Read more Research Article  |  ULTRASOUND IMAGING Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale By Baptiste Heiles, Flora Nelissen, et al. Read more Research Article  |  MOLECULAR BIOLOGY Exogenous RNA surveillance by proton-sensing TRIM25 By Myeonghwan Kim, Youngjoon Pyo, et al. Read more Research Article  |  CATALYSIS Homogeneous-heterogeneous bifunctionality in Pd-catalyzed vinyl acetate synthesis By Deiaa M. Harraz, Kunal M. Lodaya, et al. Read more Research Article  |  OSTEOARTHRITIS Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling By Yuanheng Yang, Cong Hao, et al. Read more Research Article  |  HUMAN GENETICS Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes By Jorge Diego Martin-Rufino, Alexis Caulier, et al. Read more Research Article  |  NEURODEVELOPMENT Ectoderm barcoding reveals neural and cochlear compartmentalization By Sandra de Haan, Jingyan He, et al. Read more Research Article  |  CHEMICAL BIOLOGY Protein editing using a coordinated transposition reaction By Yi Hua, Nicholas E. S. Tay, et al. Read more Research Article  |  VACCINATION Vaccine-enhanced competition permits rational bacterial strain replacement in the gut By Verena Lentsch, Aurore Woller, et al. Read more Research Article  |  METALLURGY Superior resistance to cyclic creep in a gradient structured steel By Qingsong Pan, Kunqing Ding, et al. Read more Research Article  |  SOLAR CELLS Strain-induced rubidium incorporation into wide-bandgap perovskites reduces photovoltage loss By Likai Zheng, Mingyang Wei, et al. Read more Research Article  |  NEUROIMMUNOLOGY Meningeal regulatory T cells inhibit nociception in female mice By Élora Midavaine, Beatriz C. Moraes, et al. Read more Research Article  |  ANIMAL COMMUNICATION Extensive compositionality in the vocal system of bonobos By M. Berthet, M. Surbeck, et al. Read more Research Article  |  CELL BIOLOGY Tissue-like multicellular development triggered by mechanical compression in archaea By Theopi Rados, Olivia S. Leland, et al. Read more Errata Erratum for the Research Article “Whale song shows language-like statistical structure” by I. Arnon et al. Read more Careers Working Life Taking flight By Melanie Ortiz Alvarez De La Campa Read more New Products New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers. Read more Essay Essay  |  Bioinnovation Empower the age of smart mRNA medicine: Programmable RNA sensor and molecular tools refine therapeutic payload production By Xiaojing Gao Programmable RNA sensor and molecular tools refine therapeutic payload production Read more Essay  |  Bioinnovation Dancing with the cells: How acoustically levitating a diamond enabled a redesign of biotech automation By Luke Cox How acoustically levitating a diamond enabled a redesign of biotech automation Read more Essay  |  Bioinnovation mRNA binding proteins join the longevity pipeline: Rebuilding muscle through the power of mRNA binding protein therapeutics By Dounia Abbadi Rebuilding muscle through the power of mRNA binding protein therapeutics Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. 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