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Brought to you by New England Biolabs  VOLUME 388 | ISSUE 6743 | 11 APR 2025 Editorial Editorial AI drug development’s data problem By E. Richard Gold, Robert Cook-Deegan Read more News In Brief News at a glance Read more In Depth  |  Trump Administration Health agencies reeling as leaders, staff slashed By Jocelyn Kaiser NIH loses five heads of institutes; FDA and CDC offices also gutted Read more In Depth  |  Climate A global warming ‘hole’ where you’d least expect it By Vaishnavi Chandrashekhar India has so far warmed at about half the global average. Scientists aren’t sure why Read more In Depth  |  Infectious Diseases Squirrels in Ivory Coast may be an animal reservoir for mpox By Kai Kupferschmidt Outbreak in mangabeys gives researchers a unique opportunity to study the virus’ elusive origins Read more In Depth  |  Global Health No one can replace the U.S. as it retreats from global health By Ida Jooste Other countries, foundations, international groups are unable to make up for billions in Trump administration cuts Read more In Depth  |  Agriculture Is Indonesia’s rice farming megaproject doomed to fail? By Dyna Rochmyaningsih Poor soils and dry climate could undermine effort to add 1 million hectares of paddies, scientists say Read more In Depth  |  Arms Control Landmark bioweapons pact needs upgrade, researchers say By Richard Stone Technological advances are challenging the effectiveness of the 50-year-old Biological Weapons Convention Read more In Depth  |  Proteomics The AI revolution comes to protein sequencing By Robert F. Service By identifying unknown proteins, new systems could aid research in many areas Read more Feature A passion for bats By Orji Sunday Biologists Benneth Obitte and Inoro Tanshi are exploring Nigeria’s bat diversity, and trying to save it Read more Insights Expert Voices Protecting pieces of us: The need for Indigenous perspectives in the fuzzy world of biometric data regulation By Tahu Kukutai Read more Perspective  |  Particle Physics Closing the gap in the neutrino mass By Loredana Gastaldo New measurements make an important step toward demystifying the fundamental particle Read more Perspective  |  Additive Manufacturing Reformation by light By Xabier Lopez de Pariza, Haritz Sardon Light-driven chemistry enables three-dimensional printing of recyclable polymer parts Read more Perspective  |  Plant Sciences A natural defense against plant disease By Comzit Opachaloemphan, Sheng Yang He Wild citrus plants contain a natural defense against a devastating bacterial disease Read more Perspective  |  Neuroscience How does cancer affect motivation? By Jeffrey W. Dalley, Mary-Ellen Lynall Inflammatory cytokines hijack a brain circuit to cause apathy in cancer Read more Policy Forum  |  Health and Safety Fixing the science of digital technology harms By Amy Orben, J. Nathan Matias Technology development outpaces scientific assessment of impacts Read more Books et al.  |  Evolutionary Biology Diversity is a feature, not a bug By Justin R. Garcia An interdisciplinary tour of sexual strategies in the animal kingdom offers lessons for humanity Read more Books et al.  |  Political Science Empires and their philosophies By Jorge Cañizares-Esguerra Conflicting ideas about citizenship and sovereignty shaped the Americas, argues a historian Read more Letter Implementing equitable wildfire response plans By Junxiang Xu, Divya Jayakumar Nair, et al. Read more Letter Editor’s note By H. Holden Thorp Read more Letter Modernizing wildfire management in China By Junran Li Read more Letter Wildfires jeopardize drinking water safety By Xuan Li, Qizi Fu, et al. Read more Research Research Highlights In Science Journals By Sacha Vignieri, Hannah Isles, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Angela Hessler, Sumin Jin, et al. Editors’ selections from the current scientific literature Read more Research Article  |  METABOLISM Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues By Emily M. Walker, Gemma L. Pearson, et al. Read more Research Article  |  SIGNAL TRANSDUCTION Structural pathway for PI3-kinase regulation by VPS15 in autophagy By Annan S. I. Cook, Minghao Chen, et al. Read more Research Article  |  NEUROSCIENCE A neuroimmune circuit mediates cancer cachexia-associated apathy By Xiaoyue Aelita Zhu, 朱晓悦, et al. Read more Research Article  |  IMMUNOLOGY A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals By Katarzyna Jobin, Deeksha Seetharama, et al. Read more Research Article  |  EVOLUTION The genetic architecture of and evolutionary constraints on the human pelvic form By Liaoyi Xu, Eucharist Kun, et al. Read more Research Article  |  MOLECULAR BIOLOGY Rules of engagement for condensins and cohesins guide mitotic chromosome formation By Kumiko Samejima, Johan H. Gibcus, et al. Read more Research Article  |  POLYMERS Circular 3D printing of high-performance photopolymers through dissociative network design By Bo Yang, Tiantian Ni, et al. Read more Research Article  |  PALEOANTHROPOLOGY A male Denisovan mandible from Pleistocene Taiwan By Takumi Tsutaya, Rikai Sawafuji, et al. Read more Research Article  |  PARTICLE PHYSICS Direct neutrino-mass measurement based on 259 days of KATRIN data By KATRIN Collaboration, Max Aker, et al. Read more Research Article  |  SELECTION Most bacterial gene families are biased toward specific chromosomal positions By Xiao-Pan Hu, Bayu Brahmantio, et al. Read more Research Article  |  PLANT PATHOLOGY Targeted MYC2 stabilization confers citrus Huanglongbing resistance By Pingzhi Zhao, Huan Yang, et al. Read more Research Article  |  QUANTUM INFORMATION Beyond-classical computation in quantum simulation By Andrew D. King, Alberto Nocera, et al. Read more Research Article  |  PARKINSON’S DISEASE Commander complex regulates lysosomal function and is implicated in Parkinson’s disease risk By Georgia Minakaki, Nathaniel Safren, et al. Read more Research Article  |  DIELECTRICS Ultrahigh capacitive energy storage through dendritic nanopolar design By Yajing Liu, Yang Zhang, et al. Read more Research Article  |  AQUATIC POLLUTION Pharmaceutical pollution influences river-to-sea migration in Atlantic salmon (Salmo salar) By Jack A. Brand, Marcus Michelangeli, et al. Read more Errata Erratum for the Research Article “Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase” by N. K. Kolas et al. Read more Errata Erratum for the Research Article “A phage tail–like bacteriocin suppresses competitors in metapopulations of pathogenic bacteria” by T. Backman et al. Read more Careers Working Life An awakening By Maria Martignoni Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. Sign up Journals Science Science Advances Science Immunology Science Robotics Science Signaling Science Translational Medicine Useful links News Careers Commentary Podcast Webinars Prizes and Awards Help Access & Subscriptions Reprints & Permissions Contact Us Follow us

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