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Brought to you by Eppendorf & Science Prize for Neurobiology Now accepting entries for the US$ 25,000 Eppendorf & Science Prize for Neurobiology Deadline: June 15, 2025 Visit www.eppendorf.com/prize VOLUME 388 | ISSUE 6748 | 15 MAY 2025 Editorial Editorial Institutionalizing politicized science By Donald Moynihan, Pamela Herd Read more News In Depth  |  U.S. Science With Trump’s cuts escalating, ‘fear factor’ silences researchers By Warren Cornwall Many worry about retribution. But for others, speaking out is worth the risk Read more In Depth  |  U.S. Science Policy Trump takes steps toward a radically different NSF By Jeffrey Mervis Democrats question latest changes in how the research agency makes grants Read more In Depth  |  Environment Project to revive Louisiana coastline runs aground By Warren Cornwall Politics and lawsuits imperil plans to divert the Mississippi River to build new land Read more In Depth  |  Drug Development AI-designed antibody candidates hit a crucial target By Robert F. Service Companies find enticing drug leads that bind to tricky cell membrane proteins Read more In Depth  |  Infectious Disease Mosquito-borne viral disease sweeps Indian Ocean islands By Meredith Wadman Safety issues with the only available vaccine are complicating the response to chikungunya Read more In Depth  |  Trump Administration Executive order on risky research brings confusion By Kai Kupferschmidt Directive aims to restrict gain-of-function studies on microbes and more, but no one knows what’s affected Read more Feature Mind reader? By Jonathan Moens A forensic technology developed in India sifts brain recordings for clues to a suspect’s guilt or innocence. Many neuroscientists are skeptical, but it is catching on in other countries Read more Commentary Expert Voices On the economic costs of ending DEI By Rohini Pande Read more Perspective  |  Microbiology Expanded utility belt for tackling bat viruses By Jie Zhou, Kwok Yung Yuen A diverse organoid panel illuminates bat-virus interactions and the potential of trans-species spillover Read more Perspective  |  Condensed Matter Physics Watching electronic ice melt By Sandeep Joy, Brian Skinner An experiment captures images of the transition between liquid and solid states of an electron system Read more Perspective  |  Cell Biology A nuclear house divided By Timothy J. Mitchison, William T. Sullivan Certain fungal plant pathogens maintain varying chromosome distributions across multiple nuclei Read more Perspective  |  Cellular Neuroscience Astrocytes, hidden puppet masters of the brain By Cagla Eroglu Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators Read more Policy Forum  |  Conservation Deliberate extinction by genome modification: An ethical challenge By Gregory E. Kaebnick, James P. Collins, et al. What circumstances might justify deliberate, full extinction of a species? Read more Books et al.  |  Laboratory Animals Very good dogs By Barbara J. King The beagle has sacrificed much for biomedical research—was it worth it? Read more Books et al.  |  Energy Energy’s international history and future By Rasoul Sorkhabi Scholars find lessons for today in foundational energy texts with an emphasis on the Global South Read more Letter Leaving synthetic pesticides behind By Nian-Feng Wan, Ben A. Woodcock, et al. Read more Letter Revolutionize textile recycling By Leilei Dai, Roger Ruan, et al. Read more Letter El Salvador revives metallic mining risks By Diego J. Arévalo-Ayala, Guillermo Funes, et al. Read more Research Research Highlights In Science Journals By Bianca Lopez, Jelena Stajic, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Bianca Lopez, Priscilla N. Kelly, et al. Editors’ selections from the current scientific literature Read more Research Article  |  POPULATION GENETICS From North Asia to South America: Tracing the longest human migration through genomic sequencing By Elena S. Gusareva, Amit Gourav Ghosh, et al. Read more Research Article  |  POPULATION GENETICS Admixture’s impact on Brazilian population evolution and health By Kelly Nunes, Marcos Araújo Castro e Silva, et al. Read more Research Article  |  VIROLOGY Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis By Ruchao Peng, Xin Xu, et al. Read more Research Article  |  SIGNAL TRANSDUCTION Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes By Feng-Jie Wu, Pascal S. Rieder, et al. Read more Research Article  |  VIROLOGY Cryptic infection of a giant virus in a unicellular green alga By Maria P. Erazo-Garcia, Uri Sheyn, et al. Read more Research Article  |  CRISPR Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase By Isaac P. Witte, George D. Lampe, et al. Read more Research Article  |  BATTERIES Halide segregation to boost all-solid-state lithium-chalcogen batteries By Jieun Lee, Shiyuan Zhou, et al. Read more Research Article  |  MESOSCOPIC PHYSICS Anyon braiding and telegraph noise in a graphene interferometer By Thomas Werkmeister, James R. Ehrets, et al. Read more Research Article  |  2D MATERIALS Imaging quantum melting in a disordered 2D Wigner solid By Ziyu Xiang, Hongyuan Li, et al. Read more Research Article  |  RANGE SHIFTS Limited evidence for range shift–driven extinction in mountain biota By Yi-Hsiu Chen, Jonathan Lenoir, et al. Read more Research Article  |  PALEONTOLOGY Sustainability insights from Late Pleistocene climate change and horse migration patterns By Yvette Running Horse Collin, Tašunke Iyanke Wiƞ, et al. Read more Research Article  |  ORGANOIDS Diverse bat organoids provide pathophysiological models for zoonotic viruses By Hyunjoon Kim, Seo-Young Heo, et al. Read more Research Article  |  NEUROPHYSIOLOGY GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity By Kevin A. Guttenplan, Isa Maxwell, et al. Read more Research Article  |  NEUROPHYSIOLOGY Norepinephrine changes behavioral state through astroglial purinergic signaling By Alex B. Chen, Marc Duque, et al. Read more Research Article  |  NEUROPHYSIOLOGY Norepinephrine signals through astrocytes to modulate synapses By Katheryn B. Lefton, Yifan Wu, et al. Read more Research Article  |  GENETICS Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi By Yan Xu, Lei Tian, et al. Read more Errata Erratum for the Report “Recognition of a ubiquitous self antigen by prostate cancer–infiltrating CD8+ T lymphocytes” by P. A. Savage et al. Read more Careers Working Life The cost of health By Lara de Macedo Monteiro Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. 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