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Brought to you by New England Biolabs VOLUME 389 | ISSUE 6756 | 10 JUL 2025 Editorial Editorial Auditors can’t save carbon offsets By Cynthia Giles, Cary Coglianese Read more News In Depth  |  Research Community U.S. scientific workforce is set to shrink sharply By Katie Langin Funding cuts threaten jobs at all levels. “It’s a nightmare,” one faculty member says Read more In Depth  |  Biology Scientists identify culprit behind biggest ever U.S. honey bee die-off By Joanna Thompson USDA research points to viruses spread by pesticide-resistant mites, indicating a worrying trend Read more In Depth  |  Archaeology AI challenge to find lost Amazonian cities draws critics By Sofia Moutinho Scientists claim OpenAI’s contest ignores heritage protection norms Read more In Depth  |  Biology End looms for protein contest? By Robert F. Service NIH has not committed to continuing support for contest that inspired AI tools for predicting how proteins would fold Read more In Depth  |  Remote Sensing Giant radar satellite set to probe Earth’s shifts and shudders By Michael Greshko NASA and India’s $1.5 billion NISAR mission promises global time lapses of the planet’s ever-changing land and ice Read more In Depth  |  Funding Should grant applicants judge competitors’ proposals? By Jeffrey Brainard Distributed peer review, which enlists more researchers in the process, gets two real-world tests Read more Feature Atomic explosion By Adrian Cho Quantum computers fashioned out of individual atoms are poised to lead the field Read more Commentary Expert Voices Cities as transformative agents for global sustainability By Xuemei Bai Read more Perspective  |  Chemistry Electronically diverse carbenes By André B. Charette Metal carbenes with different polarities are generated from a single class of precursor Read more Perspective  |  Neurotechnology Integrated prostheses restore dynamic movement By Lee Fisher Combining multiple neurotechnologies allows amputees to perform complex physical activities Read more Perspective  |  Neuroimmunology Replacing microglia to treat a brain disease By Siling Du, Jonathan Kipnis Swapping out the brain’s immune cells can slow progression of a devastating neurological disease Read more Perspective  |  Cell Biology Organelles share the load By Marc Fransen Peroxisome-mitochondria contact sites manage mitochondrial oxidative stress Read more Books et al.  |  Artificial Intelligence Following in our footsteps By Adrian Woolfson Nurturing AI while it is young will help it achieve an ethical adulthood Read more Books et al.  |  Science Lives The boundless energy, and ego, of Luis Alvarez By Ananyo Bhattacharya A new biography offers a definitive portrait of the intellectually restless physicist Read more Letter State law threatens Brazil’s high grasslands By Glayson A. Bencke, Marcelo M. Madeira, et al. Read more Letter China’s antismog push faces challenges By Yi Qiang, Qiang Cao, et al. Read more Letter PEPFAR disruptions could cause HIV resurgence By Kimberly A. Powers, Justin Lessler, et al. Read more Reviews Review  |  NEUROSCIENCE Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal By Samantha A. Keil, Deidre Jansson, et al. Read more Research Research Highlights In Science Journals By Sacha Vignieri, Sarah H. Ross, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Yevgeniya Nusinovich, L. Bryan Ray, et al. Editors’ selections from the current scientific literature Read more Research Article  |  NEUROSCIENCE Human neuron subtype programming via single-cell transcriptome-coupled patterning screens By Hsiu-Chuan Lin, Jasper Janssens, et al. Read more Research Article  |  EVOLUTION A single theory for the evolution of sex chromosomes and the two rules of speciation By Thomas Lenormand, Denis Roze Read more Research Article  |  NEUROSCIENCE Microglia replacement halts the progression of microgliopathy in mice and humans By Jingying Wu, Yafei Wang, et al. Read more Research Article  |  MOLECULAR BIOLOGY Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization By Sebastian Balch, Zala Sekne, et al. Read more Research Article  |  PROSTHETICS Tissue-integrated bionic knee restores versatile legged movement after amputation By Tony Shu, Daniel Levine, et al. Read more Research Article  |  RIVER DYNAMICS Single- and multithread rivers originate from (im)balance between lateral erosion and accretion By Austin J. Chadwick, Evan Greenberg, et al. Read more Research Article  |  MUTUALISM Compartmentalization reduces conflict in multipartner plant-insect symbioses By Guillaume Chomicki, Dirk Metzler, et al. Read more Research Article  |  CELL BIOLOGY ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox By Laura F. DiGiovanni, Prabhsimran K. Khroud, et al. Read more Research Article  |  DOG DOMESTICATION Origins and diversity of Greenland’s Qimmit revealed with genomes of ancient and modern sled dogs By T. R. Feuerborn, M. Appelt, et al. Read more Research Article  |  IMMUNOLOGY Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage By Daisy A. Hoagland, Patricia Rodríguez-Morales, et al. Read more Research Article  |  OCEAN ECOLOGY Overturning circulation structures the microbial functional seascape of the South Pacific By Bethany C. Kolody, Rohan Sachdeva, et al. Read more Research Article  |  ORGANIC CHEMISTRY Harnessing carbene polarity: Unified catalytic access to donor, neutral, and acceptor carbenes By Khue N. M. Nguyen, Xueling Mo, et al. Read more Research Article  |  SEISMOLOGY The forearc seismic belt: A fluid pathway constraining down-dip megathrust earthquake rupture By Rintaroh Suzuki, Naoki Uchida, et al. Read more Research Article  |  SOLAR CELLS Stable and uniform self-assembled organic diradical molecules for perovskite photovoltaics By Wenping Wu, Han Gao, et al. Read more Research Article  |  NEUROPHYSIOLOGY Discrete spatiotemporal encoding of striatal dopamine transmission By Andrew G. Yee, Yini Liao, et al. Read more Careers Working Life A fish out of water By Andrea Lius Read more New Products New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers. 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