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Brought to you by AI and Mental Health Conference 2025 VOLUME 389 | ISSUE 6758 | 24 JUL 2025 Editorial Editorial Eighty years at the nuclear brink By Ernest J. Moniz Read more News In Depth  |  Scientific Publishing Science retracts ‘arsenic life’ paper despite protests By Catherine Offord Study authors and others question belated decision, whereas some critics of work are pleased Read more In Depth  |  Climate Change ‘This is delicate.’ Chemically altering swamps could help curb methane emissions By Paul Voosen Rising levels of potent greenhouse gas prompt a new kind of geoengineering Read more In Depth  |  Astronomy All-sky radio telescopes ditch the dish By Dennis Normile Arrays of simple antennas hunt for nearby fast radio bursts Read more In Depth  |  Research Budgets Europe plans to double flagship funding scheme By Cathleen O’Grady Starting in 2028, the next iteration of Horizon Europe will also focus on boosting competitiveness Read more In Depth  |  U.S. Funding New scheme for overhead payments faces doubts By Jeffrey Mervis FAIR Model aims to head off drastic cuts in government payments, but some say it’s too costly and complex Read more In Depth  |  Funding ‘Wandering scholars’ analysis reveals how location drives productivity By Katie Langin Concentrating funding at high-powered universities can maximize output but may sacrifice broader benefits Read more In Depth  |  Trump Administration EPA begins to dismantle its research office By Erik Stokstad Extensive layoffs could have wide-ranging impacts on environmental science Read more Feature The riddle of coexistence By Ann Gibbons Two million years ago, three kinds of hominins walked the same valley in South Africa. Did they meet—and compete? Read more Commentary Expert Voices Why AI chatbots lie to us By Melanie Mitchell Read more Perspective  |  Signal Transduction Harnessing insulin biology to treat diabetes and cancer By Giovanni Solinas Small molecules are used to target the insulin signaling molecular machinery Read more Perspective  |  Immunotherapy Beyond the native repertoire By Grant H. Hickok, Ingunn M. Stromnes Design of T cell receptors by artificial intelligence is poised to accelerate cancer immunotherapy Read more Perspective  |  Materials Science Minuscule vibrations, uncovered By Toma Susi Computational imaging resolves atomic vibrations at picometer scale Read more Perspective  |  Marine Conservation A catch in ocean conservation By Boris Worm Satellite imagery reveals global patterns of industrial fishing across marine protected areas Read more Perspective  |  Quantum Computing Flat optics produces quantum graphs By Maxim R. Shcherbakov A miniature device links multiple photon paths for bespoke entanglement Read more Policy Forum  |  Conservation Policy Proactive assisted gene flow for Caribbean corals in an era of rapid coral reef decline By Andrew C. Baker, Iliana B. Baums, et al. Regulatory action could facilitate cross-border efforts to retain ecosystem function Read more Books et al.  |  Earth Science Stone and its stories By Riley Black A journalist pens a love letter to geologic history Read more Books et al.  |  Archaeology Sensing early civilizations By Patrick E. McGovern Armchair archaeologists summon ancient tastes, sights, and sounds to understand the past Read more Letter Reinstate the National Climate Assessment By Craig E. Landry, Lynne Lewis, et al. Read more Letter NASA Earth Science Division provides key data By Dylan B. Millet, Belay B. Demoz, et al. Read more Letter Weaponizing Europe’s borders imperils wildlife By Katarzyna Nowak, Jacopo Cerri, et al. Read more Reviews Review  |  AGRICULTURE Steering plant-soil feedback for sustainable agriculture By Guangzhou Wang, Wim H. van der Putten, et al. Read more Research Research Highlights In Science Journals By Shahid Naeem, Jesse Smith, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Sacha Vignieri, Sarah H. Ross, et al. Editors’ selections from the current scientific literature Read more Research Article  |  PROTEIN EVOLUTION Genetics, energetics, and allostery in proteins with randomized cores and surfaces By Albert Escobedo, Gesa Voigt, et al. Read more Research Article  |  IMMUNOLOGY A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway By Delphine Bonhomme, Hugo Vaysset, et al. Read more Research Article  |  DRUG DEVELOPMENT A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors By Caroline Weller, G. Leslie Burnett, et al. Read more Research Article  |  MOLECULAR BIOLOGY Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation By Ajay S. Labade, Zachary D. Chiang, et al. Read more Research Article  |  LEPROSY Pre-European contact leprosy in the Americas and its current persistence By Maria Lopopolo, Charlotte Avanzi, et al. Read more Research Article  |  MARINE HEATWAVES Record-breaking 2023 marine heatwaves By Tianyun Dong, Zhenzhong Zeng, et al. Read more Research Article  |  PROTEIN DESIGN De novo design and structure of a peptide–centric TCR mimic binding module By Karsten D. Householder, Xinyu Xiang, et al. Read more Research Article  |  PROTEIN DESIGN De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells By Kristoffer Haurum Johansen, Darian Stephan Wolff, et al. Read more Research Article  |  PROTEIN DESIGN Design of high-specificity binders for peptide–MHC-I complexes By Bingxu Liu, Nathan F. Greenwood, et al. Read more Research Article  |  MARINE PROTECTED AREAS Little-to-no industrial fishing occurs in fully and highly protected marine areas By Jennifer Raynor, Sara Orofino, et al. Read more Research Article  |  MARINE PROTECTED AREAS Global patterns and drivers of untracked industrial fishing in coastal marine protected areas By Raphael Seguin, Frédéric Le Manach, et al. Read more Research Article  |  SIGNAL TRANSDUCTION Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin By Koji Terayama, Shinji Furuzono, et al. Read more Research Article  |  SIGNAL TRANSDUCTION BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction By Dhirendra K. Simanshu, Rui Xu, et al. Read more Research Article  |  QUANTUM METASURFACES Metasurface quantum graphs for generalized Hong-Ou-Mandel interference By Kerolos M. A. Yousef, Marco D’Alessandro, et al. Read more Research Article  |  PHONON PHYSICS Atom-by-atom imaging of moiré phasons with electron ptychography By Yichao Zhang, Ballal Ahammed, et al. Read more Errata Erratum for the Review “Dispersed components drive temperature sensing and response in plants” by A. Singh Yadav et al. Read more Retraction Retraction By H. Holden Thorp Read more Careers Working Life Running out of road By Na Zhao Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. 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