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Brought to you by New England Biolabs VOLUME 389 | ISSUE 6760 | 7 AUG 2025 Special Issue Introduction to Special Issue  |  INTRODUCTION The multifunctional immune system By Sarah Ross, Caroline Ash Read more Special Issue Review  |  REVIEW Evolution of antiviral host defenses against a backdrop of endogenous retroelements By George Kassiotis, Jonathan P. Stoye Read more Special Issue Review Immune system influence on physiology By Matthias Nahrendorf, Florent Ginhoux, et al. Read more Special Issue Review Sex differences in tissue-specific immunity and immunology By Sonia Sharma, Alicia Gibbons, et al. Read more Special Issue Review Convergence and divergence of individual immune responses over the life course By C. Jessica E. Metcalf, Andrea L. Graham, et al. Read more Editorial Editorial The Columbia deal is a tragic wake-up call By H. Holden Thorp Read more News In Depth  |  Research Ethics Study used DNA from thousands—without consent By Annika Inampudi iPsych, which investigates the genetics of psychiatric disorders, has sent 140,000 opt-out notices amid backlash Read more In Depth  |  U.S. Science Funding Senate panel rejects Trump’s plan to slash NIH’s budget By Jocelyn Kaiser Bipartisan support for agency challenges proposed reorganization and overhead costs cap Read more In Depth  |  Plant Biology Thank ketchup, and interbreeding, for your French fries By Erik Stokstad Hybridization 9 million years ago gave potatoes the genetic knack to develop tubers, a new study finds Read more In Depth  |  Scientific Integrity Study reveals industrial-scale publishing fraud By Cathleen O’Grady Sophisticated global networks are infiltrating journals to publish fake papers Read more In Depth  |  Artificial Intelligence AI-generated text surges in research papers By Phie Jacobs One-fifth of computer science papers may include AI-written sentences Read more Feature Losing protection By Martin Enserink The United States helped beat back malaria in Guinea. Now, the disease is set to soar Read more Commentary Expert Voices Census in crisis—further erasure of Indigenous Peoples? By Tahu Kukutai Read more Perspective  |  Biomaterials Hardening nature’s toughest teeth By André Scheffel A protein that underlies the mineralization of chiton teeth is revealed Read more Perspective  |  Optoelectronics Moiré eyes detect the dim By Denis Bandurin Unusual electronic behavior of a moiré superlattice helps detect a single light particle Read more Perspective  |  Neuroscience Improving Alzheimer’s disease immunotherapy By Mengen Xing, Weihong Song A modified antibody targeting amyloid-β reduces adverse events and increases efficacy in a mouse model Read more Perspective  |  Immunology Opening the gateway to food-induced anaphylaxis By Tamara T. Haque, Mark H. Kaplan Cysteinyl leukotrienes are important drivers of the anaphylactic response to ingested food antigens Read more Policy Forum  |  Quantum Technology Quantum technology governance: A standards-first approach By Mateo Aboy, Urs Gasser, et al. Standards offer a flexible, globally harmonized path to govern early-stage quantum technologies while preserving innovation, security, and international cooperation Read more Books et al.  |  Classics Revisited Revisiting the human sociobiology debate By Gillian R. Brown, H. Clark Barrett, et al. What have we learned 50 years on? Read more Books et al.  |  Science Lives Roxie Laybourne, the first forensic ornithologist By Vijaysree Venkatraman A new biography probes the life of a taxidermist turned avian investigator Read more Letter Brazil’s “devastation bill” empowers criminals By Andre Giles, Bernardo M. Flores Read more Letter Brazil’s dangerous environmental licensing bill By Emanuela W. A. Weidlich Read more Letter Community support for inclusive US education By Emily P. Driessen, A. Kelly Lane Read more Letter  |  Submit Now NextGen Voices: National Assessments in Verse Read more Research Research Highlights In Science Journals By Di Jiang, Mark Aldenderfer, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Sacha Vignieri, L. Bryan Ray, et al. Editors’ selections from the current scientific literature Read more Research Article  |  CELL BIOLOGY The membrane skeleton is constitutively remodeled in neurons by calcium signaling By Evan Heller, Naina Kurup, et al. Read more Research Article  |  IMMUNOLOGY Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice By Laura R. Hoyt, Elise Liu, et al. Read more Research Article  |  IMMUNOLOGY Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens By Nathaniel D. Bachtel, Jaime L. Cullen, et al. Read more Research Article  |  NEUROSCIENCE Transferrin receptor–targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA By Michelle E. Pizzo, Edward D. Plowey, et al. Read more Research Article  |  DISEASE GENOMICS Predicting expression-altering promoter mutations with deep learning By Kishore Jaganathan, Nicole Ersaro, et al. Read more Research Article  |  SYNTHETIC BIOLOGY An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli By Christian S. Diercks, Philipp Sondermann, et al. Read more Research Article  |  MAGNETIC SENSING Strain-coupled, crystalline polymer-inorganic interfaces for efficient magnetoelectric sensing By Binbin He, Yuanyuan He, et al. Read more Research Article  |  METALLURGY Three-dimensional nucleation and growth of deformation twins in magnesium By Sangwon Lee, Michael Pilipchuk, et al. Read more Research Article  |  BIOMINERALS Radular teeth matrix protein 1 directs iron oxide deposition in chiton teeth By Michiko Nemoto, Koki Okada, et al. Read more Research Article  |  OPTOELECTRONICS Single-photon detection enabled by negative differential conductivity in moiré superlattices By Krystian Nowakowski, Hitesh Agarwal, et al. Read more Research Article  |  CHEMICAL PHYSICS Imaging collective quantum fluctuations of the structure of a complex molecule By Benoît Richard, Rebecca Boll, et al. Read more Careers Working Life How a diagnosis altered my path By Matteo De Vuyst Read more New Products New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers. 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