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Brought to you by AI and Mental Health Conference 2025 VOLUME 389 | ISSUE 6763 | 28 AUG 2025 Editorial Editorial Taking nuclear energy to the Moon By Kathryn Huff Read more News In Depth  |  Science Policy Supreme Court quashes restoration of NIH grants By Meredith Wadman, John Travis Emergency ruling may prompt Trump administration to again cancel research it dislikes Read more In Depth  |  Genetics Gaps remain in college sports’ 15-year-old sickle cell policy By Rodrigo Pérez Ortega Report recommends education, genetic counseling with NCAA screening Read more In Depth  |  Artificial Intelligence AI hypotheses lag human ones when put to the test By Jeffrey Brainard Machines still face hurdles in identifying fresh research paths, study suggests Read more In Depth  |  Origin of Life New clues found about the assembly of life’s first proteins By Robert F. Service Lab study shows how RNA could have helped amino acids join up—without preexisting protein machinery Read more In Depth  |  Earth Science Europe’s biggest quake may foretell Atlantic ‘ring of fire’ By Evan Howell Earth’s mantle is peeling from the crust in the eastern Atlantic, a possible sign of the ocean’s eventual closure Read more Feature Bones beneath the runway By Rodrigo Pérez Ortega How a military megaproject led to Mexico’s biggest paleontological discovery—and is reshaping what we know about mammoths Read more Commentary Expert Voices Unraveling the arc of vaccine progress By Seth Berkley Read more Perspective  |  Evolutionary Biology The rise of rideable horses By Laurent Frantz Early horse riders selected a rare mutation in a single gene to enhance rideability Read more Perspective  |  Neuroscience Mapping the anatomy of placebo analgesia By Massieh Moayedi, Lauren Y. Atlas The identification of somatotopy in brainstem pain modulatory pathways could help treat chronic pain Read more Perspective  |  Textile Engineering Sustainable personal cooling in a warming world By Dahua Shou, Ziqi Li Advanced textiles and intelligent wearable devices can provide cooling under extreme heat Read more Perspective  |  Geology Vegetation steers a river’s path By Jim Pizzuto Evolution of plants could have modified ancient river trajectories Read more Perspective  |  Genetics Penetrance and variant consequences—Two sides of the same coin? By Harper Raiken, Amelie Stein To get more out of genome sequences, the effects of variants need to be quantified Read more Books et al.  |  Higher Education Academic leadership in uncertain times By Susan Elrod A former college president offers advice for administrators navigating unprecedented challenges Read more Books et al.  |  Science and Society Mars mania and the making of scientific authority By Dov Greenbaum Twentieth-century speculation about martian life shed light on the interplay of science and culture Read more Books et al.  |  Podcast Playing Possum: How Animals Understand Death Read more Letter Copper threatens marine ecosystems By Luhua Yang, Shun Li, et al. Read more Letter Curtail North Korea’s illegal wildlife trade By Joshua Elves-Powell, Jan C. Axmacher, et al. Read more Letter  |  Outside the Tower Creating connection with wings and strings By Christine Harrison Elliott, Emily Jean Justus Read more Analysis Policy Article  |  Pharmaceutical Trade Supply-chain vulnerabilities in critical medicines: A persistent risk to pharmaceutical security By Giona Casiraghi, Georges Andres, et al. Asymmetries in the global supply chain expose countries to systemic vulnerabilities that require investment in visibility, coordination, and resilience Read more Reviews Review  |  AIR POLLUTION Secondary organic aerosol in urban China: A distinct chemical regime for air pollution studies By Ru-Jin Huang, Yong Jie Li, et al. Read more Research Research Highlights In Science Journals By Angela Hessler, Bianca Lopez, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Caroline Ash, Sarah Lemprière, et al. Editors’ selections from the current scientific literature Read more Research Article  |  TISSUE IMMUNOLOGY Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential By Xiaotong Yu, Yanan Hu, et al. Read more Research Article  |  MEDICAL GENOMICS Machine learning–based penetrance of genetic variants By Iain S. Forrest, Ha My T. Vy, et al. Read more Research Article  |  CELL BIOLOGY A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy By Guoping Li, Lingfei Sun, et al. Read more Research Article  |  CELL BIOLOGY Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos By Yinwen Liang, Richard Koche, et al. Read more Research Article  |  PAIN Somatotopic organization of brainstem analgesic circuitry By Lewis S. Crawford, Fernando A. Tinoco Mendoza, et al. Read more Research Article  |  AIR POLLUTION Heavily polluted Tijuana River drives regional air quality crisis By Benjamin Rico, Kelley C. Barsanti, et al. Read more Research Article  |  PLANETARY SCIENCE Seismic evidence for a highly heterogeneous martian mantle By Constantinos Charalambous, W. Thomas Pike, et al. Read more Research Article  |  RESTORATION ECOLOGY Yellowstone’s free-moving large bison herds provide a glimpse of their past ecosystem function By Chris Geremia, E. William Hamilton, et al. Read more Research Article  |  PROTEOSTASIS Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control By Daniel B. Grabarczyk, Julian F. Ehrmann, et al. Read more Research Article  |  RIVER DYNAMICS Vegetation changes the trajectory of river bends By Michael Hasson, Alvise Finotello, et al. Read more Research Article  |  NANOMATERIALS Deciphering icosahedra structural evolution with atomically precise silver nanoclusters By Feng Hu, Gaoyuan Yang, et al. Read more Research Article  |  HORSE EVOLUTION Selection at the GSDMC locus in horses and its implications for human mobility By Xuexue Liu, Yaozhen Jia, et al. Read more Research Article  |  CLIMATE MITIGATION Land availability and policy commitments limit global climate mitigation from forestation By Yijie Wang, Yakun Zhu, et al. Read more Research Article  |  ROBOTICS Launching by cavitation By Dalei Wang, Zixiao Liu, et al. Read more Research Article  |  QUANTUM NETWORKS Classical-decisive quantum internet by integrated photonics By Yichi Zhang, Robert Broberg, et al. Read more Careers Working Life Growing into mentorship By Jasmine Gabriel Hughes Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. 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