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Brought to you by Science Webinars VOLUME 390 | ISSUE 6773 | 6 NOV 2025 Editorial Editorial Advancing research on financial stability and climate-related financial risk By William Pizer, James Stock Read more News In Depth  |  Science Funding Biomedical philanthropy promises dramatic expansion and AI focus By Jon Cohen Entering its second decade, the Chan Zuckerberg Initiative will make science the core mission for its founders’ billions Read more In Depth  |  Archaeology Tree rings from ancient coffins offer clues to Earth’s past By Taylor Mitchell Brown Wood from gravesites can help reconstruct historic temperatures, droughts, and floods Read more In Depth  |  Policy Thinning of DOE advisory bodies dismays researchers By Adrian Cho Department of Energy scraps committees that served as conduits to distinct research communities Read more In Depth  |  Climate Change Antarctic glacier’s retreat is fastest in modern history By Hannah Richter Tides and glacial earthquakes caused record ice loss at Hektoria Glacier Read more In Depth  |  Artificial Intelligence AI hallucinates because it’s trained to fake it till it makes it By Celina Zhao Teaching chatbots to say “I don’t know” could curb falsehoods but harm business model Read more Feature A foundation of trust By Sofia Moutinho A 3-decade partnership between archaeologists and the Kuikuro people offers a model of collaboration—and documents the complexity of early Amazonian societies Read more Commentary Expert Voices The role of organizations in fostering innovation By Imran Rasul Read more Perspective  |  Hypothesis Unbiased discovery of neuronal architectures By Jordan W. Squair, Michael A. Skinnider, et al. Comparative whole-brain and single-cell analyses identify neurons orchestrating neurological functions Read more Perspective  |  Molecular Biology Cell signaling meets gene transcription By Richard Young Receptor tyrosine kinases directly regulate RNA polymerase II in the nucleus Read more Perspective  |  Cell Biology Seipin-adipogenin controls lipid storage in fat cells By Jin Wu, Hongyuan Yang A protein complex promotes the expansion of lipid droplets during the formation of mature adipocytes Read more Perspective  |  Electronic Materials Shrinking interconnects beyond copper By Mehrdad T. Kiani, Judy J. Cha Quantum materials can speed up the information processing in a computer chip Read more Policy Forum  |  Ethics The need for a global effort to attend to human neural organoid and assembloid research By Sergiu P. Pașca, Paola Arlotta, et al. A continuing international process is needed to monitor and advise this rapidly progressing field Read more Books et al.  |  Technology Frankenstein and the problem of abandonment By Dov Greenbaum A new adaptation of the cautionary tale is an opportunity to reflect on scientific stewardship Read more Books et al.  |  Technology Platforms of power By Simson L. Garfinkel A legal scholar pushes for net neutrality and other actions to rein in tech monopolies Read more Letter FDA export restrictions threaten collaboration By Kaili Zhang, Jingyi Niu, et al. Read more Letter Protect Iraq’s Mesopotamian Marshes By Sarmad Dashti Latif Read more Letter Britain must step up on AI policy By George Breckenridge Read more Reviews Review  |  PLANT SCIENCE Unlocking the potential of brassinosteroids: A path to precision plant engineering By Nemanja Vukašinović, Trevor M. Nolan, et al. Read more Research Research Highlights In Science Journals By Rachel Wood, Jake S. Yeston, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Madeleine Seale, Marc S. Lavine, et al. Editors’ selections from the current scientific literature Read more Research Article  |  MOLECULAR BIOLOGY Repair of DNA double-strand breaks leaves heritable impairment to genome function By Susanne Bantele, Irene Mordini, et al. Read more Research Article  |  SYNTHETIC BIOLOGY Deep generative models design mRNA sequences with enhanced translational capacity and stability By He Zhang, Hailong Liu, et al. Read more Research Article  |  CELL BIOLOGY Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex By Chao Li, Xue-Nan Sun, et al. Read more Research Article  |  MOLECULAR BIOLOGY Direct targeting and regulation of RNA polymerase II by cell signaling kinases By Preeti Dabas, Meritxell B. Cutrona, et al. Read more Research Article  |  IMMUNOLOGY The anti-inflammatory activity of IgG is enhanced by co-engagement of type I and II Fc receptors By Andrew T. Jones, Alessandra E. Marino, et al. Read more Research Article  |  CARDIOLOGY Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy By Ross C. Bretherton, Isabella M. Reichardt, et al. Read more Research Article  |  ULTRAFAST DYNAMICS Ultrafast inverse chirality-induced spin selectivity observed by THz emission By Yifan Dong, Aeron McConnell, et al. Read more Research Article  |  QUANTUM SIMULATION Probing critical phenomena in open quantum systems using atom arrays By Fang Fang, Kenneth Wang, et al. Read more Research Article  |  CLIMATE IMPACTS Extreme warming of Amazon waters in a changing climate By Ayan Santos Fleischmann, Fabrice Papa, et al. Read more Research Article  |  NONLINEAR PHOTONICS Multi-timescale frequency-phase matching for high-yield nonlinear photonics By Mahmoud Jalali Mehrabad, Lida Xu, et al. Read more Research Article  |  METALLURGY Strengthening Ni alloys with nanoscale interfaces of negative excess energy By J. X. Li, Z. H. Jin, et al. Read more Research Article  |  HYDROECOLOGY River metabolism in the contiguous United States: A West of extremes By Taylor Maavara, Zimin Yuan, et al. Read more Research Article  |  SEA ICE Cosmic dust reveals dynamic shifts in central Arctic sea-ice coverage over the past 30,000 years By Frank J. Pavia, Jesse R. Farmer, et al. Read more Research Article  |  VOLCANOES Shear-induced bubble nucleation in magmas By Olivier Roche, Jean-Michel Andanson, et al. Read more Research Article  |  SOLAR CELLS Homogenized chlorine distribution for >27% power conversion efficiency in perovskite solar cells By Zhuang Xiong, Qian Zhang, et al. Read more Careers Working Life When ‘we’ turns wicked By Sorin M. S. Krammer Read more New Products New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers. Read more Essay Essay  |  Social Sciences Understanding nature and nurture: Statistical and AI innovations uncover how genes and environment shape human health By Jiacheng Miao Statistical and AI innovations uncover how genes and environment shape human health Read more Essay  |  Social Sciences The normalization of (almost) everything: Our minds can get used to anything, and even crises start feeling normal By Rachit Dubey Our minds can get used to anything, and even crises start feeling normal Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. 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