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Brought to you by New England Biolabs  VOLUME 390 | ISSUE 6777 | 4 DEC 2025 Special Issue Introduction to Special Issue  |  A quantum world A quantum centenary By Sumin Jin, Jelena Stajic, et al. Read more Perspective  |  A Quantum World One hundred years of quantum mechanics By Marlan O. Scully, William G. Unruh Quantum mechanics has gone from a theory in test to becoming the foundation of new technologies Read more Perspective  |  A Quantum World Dawn of quantum simulators By Pedram Roushan, Leigh Martin Large-scale quantum processors are beginning to uncover new physical phenomena Read more Perspective  |  A Quantum World Cracking chemistry with quantum simulations By Philipp Schleich, Alán Aspuru-Guzik Dynamic characteristics of complex chemical reactions can be accurately modeled by a quantum computer Read more Special Issue Review Challenges and opportunities for quantum information hardware By David D. Awschalom, Hannes Bernien, et al. Read more Editorial Editorial Accelerating science with AI By Darío Gil, Kathryn A. Moler Read more News In Depth  |  Biomedicine Experimental treatments target the brain’s ‘plumbing’ By Jennie Erin Smith Animal studies—and controversial human surgeries—aim to boost fluid clearance to fight neurological disease Read more In Depth  |  Infectious Diseases ‘Functional cure’ for HIV comes closer to reality By Jon Cohen Studies finger specific immune response that helps some people control the virus without drugs Read more In Depth  |  Artificial Intelligence States step up to democratize AI-tailored computers By Celina Zhao New York state is building AI-ready machines for researchers who lack access to federal or corporate supercomputers Read more In Depth  |  Infectious Diseases Abandoned antiviral shows promise against dengue By Gretchen Vogel Big Pharma maker won’t bring drug to market for crippling disease Read more In Depth  |  Policy DOE boost for AI, fusion could squeeze basic research By Adrian Cho Reorganization could shift mission of the largest U.S. funder of physical sciences Read more In Depth  |  Policy Can a smaller U.S. National Academies remain relevant? By Jeffrey Mervis Loss of federal support leads to staff layoffs and fewer committees of outside experts Read more Feature Putting the U in quantum By Zack Savitsky A century after the birth of quantum mechanics, its puzzles are pushing physicists to redefine reality—with themselves at the center Read more Commentary Expert Voices The United Nations Ocean Decade: A catalyst for international collaboration enhancing ocean monitoring and data By Patricia Miloslavich Read more Perspective  |  Social Science Political persuasion by artificial intelligence By Lisa P. Argyle Large-scale studies of persuasive artificial intelligence reveal an extensive threat of misinformation Read more Perspective  |  Structural Biology Molecular basis of DNA cross-linking by bacteria By Orlando D. Schärer The structure of the bacterial genotoxin colibactin bound to DNA shows how it might contribute to cancer risk Read more Perspective  |  Structural Biology A vision of chromosome organization By Kaite Zhang, Vijay Ramani Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure Read more Perspective  |  Cell Biology A tale of two forms of cohesin in DNA repair By Jiazhi Hu Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA Read more Books et al.  |  Medicine Centering disabled perspectives in technology By Johnathan Flowers Medical testing and devices must be reimagined to combat ableism, argues a disability scholar Read more Books et al.  |  Evolutionary Biology Painting the phylogeny of life By Yan Wong An evolutionary biologist invites readers to travel back in time to meet humanity’s distant ancestors Read more Letter Smart irrigation needs smart policies in Iran By Alireza Gohari, Julie Shortridge, et al. Read more Letter SAFE Act hinders US-China collaboration By Alex J. Yang, Richard B. Freeman, et al. Read more Letter Address domestic pressures on endangered species By Charles A. Emogor Read more Analysis Policy Article  |  Conservation Toward science-based conviction criteria to deter wildlife crime By Ruocheng Hu, Shuangqi Liu, et al. Risk assessment is needed for China’s new conviction standards based on monetary value Read more Research Research Highlights In Science Journals By Jelena Stajic, Di Jiang, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Keith T. Smith, Ekeoma Uzogara, et al. Editors’ selections from the current scientific literature Read more Research Article  |  ANTIBIOTIC RESISTANCE Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance By Adrian Cazares, Wendy Figueroa, et al. Read more Research Article  |  MOLECULAR BIOLOGY Multiscale structure of chromatin condensates explains phase separation and material properties By Huabin Zhou, Jan Huertas, et al. Read more Research Article  |  MOLECULAR BIOLOGY Cohesin guides homology search during DNA repair using loops and sister chromatid linkages By Federico Teloni, Zsuzsanna Takacs, et al. Read more Research Article  |  MOLECULAR BIOLOGY Cohesin drives chromatin scanning during the RAD51-mediated homology search By Alberto Marin-Gonzalez, Adam T. Rybczynski, et al. Read more Research Article  |  DNA DAMAGE The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin By Erik S. Carlson, Raphael Haslecker, et al. Read more Research Article  |  LARGE LANGUAGE MODELS The levers of political persuasion with conversational artificial intelligence By Kobi Hackenburg, Ben M. Tappin, et al. Read more Research Article  |  SOLAR CELLS Improved solvent systems for commercially viable perovskite photovoltaic modules By Yinke Wang, Ye Liu, et al. Read more Research Article  |  NEUTRINO PHYSICS Constraints on lepton number violation with the 2 tonne · year CUORE dataset By CUORE Collaboration Read more Research Article  |  PHASE TRANSITIONS Hexatic phase in covalent two-dimensional silver iodide By Thuy An Bui, David Lamprecht, et al. Read more Research Article  |  SYNTHETIC BIOLOGY High-fidelity human chromosome transfer and elimination By Gianluca Petris, Simona Grazioli, et al. Read more Research Article  |  ACTUATORS Semiseparated biphasic bicontinuous dielectric elastomer for high-performance artificial muscle By Xiaotian Shi, Jiang Zou, et al. Read more Research Article  |  BIOCATALYSIS Biocatalytic, asymmetric radical hydrogenation of unactivated alkenes By Jaicy Vallapurackal, Rajib Mandal, et al. Read more Research Article  |  MATERIALS DESIGN A stoichiometrically conserved homologous series with infinite structural diversity By Hengdi Zhao, Xiuquan Zhou, et al. Read more Research Article  |  PLANT SCIENCE Cell wall patterning regulates plant stem cell dynamics By Xianmiao Zhu, Xing Chen, et al. Read more Errata Erratum for the Research Article “Homogenized chlorine distribution for >27% power conversion efficiency in perovskite solar cells” by Z. Xiong et al. Read more Careers Working Life A writing pact By Arjav Shah Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. 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