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Brought to you by Science Webinars VOLUME 390 | ISSUE 6778 | 11 DEC 2025 Editorial Editorial Pandemic security needs national leadership By Maria D. Van Kerkhove, Chikwe Ihekweazu Read more News In Depth  |  Biomedicine Cancer-fighting cells made in body help patients By Mitch Leslie Approach could be faster than making CAR-T cells in the lab—and early results are encouraging Read more In Depth  |  Climate Warm, humid ‘atmospheric rivers’ threaten Antarctica By Tim Vernimmen Growing more common as the climate warms, these once-rare events could ultimately accelerate ice loss Read more In Depth  |  Seismology Replenishing sapped groundwater could trigger small earthquakes By Hannah Richter A boom in aquifer injection projects could unlock long-quiet faults Read more In Depth  |  Artificial Intelligence AI tools aim to speed up outbreak modeling By Sarah Scoles DARPA program could help researchers build transparent, editable models of viral spread in days instead of weeks Read more In Depth  |  Biomedicine Could adding light sensors to nerve cells help switch off diseases? By Kelly Servick Optogenetics is poised to move from a research tool to new therapies—if scientists can show it’s safe Read more Feature Planet protector By Robin George Andrews More than half of the “city killer” asteroids that might threaten Earth remain undiscovered. With an infrared eye, NASA’s NEO Surveyor aims to find them Read more Commentary Expert Voices Advances in reproductive technology mean rethinking the meaning of autonomy By Jackie Leach Scully Read more Perspective  |  Evolutionary Biology Infrared as a pollination signal By Beverley J. Glover, Alex A. R. Webb Relying on infrared communication over visual color could have limited cycad evolution Read more Perspective  |  Cancer Chromosome shattering in cancer By Stanley Clarke, Marcin Imieliński A protein that cuts double-stranded DNA contributes to chromosome scrambling in human cancer cells Read more Perspective  |  Materials Science Invisible heat insulators By Longnan Li, Wei Li A nanotube network with precisely engineered pores could replace insulating components in windows Read more Perspective  |  Geochemistry Deep mantle clues to Earth’s watery beginning By Michael Walter Minerals in the lower mantle may store more water than previously estimated Read more Books et al.  |  Neuroscience Dealing with distressing dreams By Jaime Herndon A sleep scientist offers hope for nightmare sufferers Read more Books et al.  |  Social Science The statusocratic dilemma By Sorin M. S. Krammer An organizational theorist probes the hidden drivers of social power Read more Letter Landmark marine mammal laws under threat By Matthew S. Leslie, Joe Roman, et al. Read more Letter Communities can enforce China’s national parks By Shuo Gao, Qinglong Shao Read more Letter Arctic route demands advanced marine coatings By Tao Zhang, Liping Wang Read more Analysis Policy Article  |  Computational Social Science Mapping the online manipulation economy By A. Dek, Y. Kyrychenko, et al. A market perspective on digital manipulation may help improve online trust and safety Read more Research Research Highlights In Science Journals By Jesse Smith, Jelena Stajic, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Caroline Ash, Stella M. Hurtley, et al. Editors’ selections from the current scientific literature Read more Research Article  |  CELL BIOLOGY Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness By Brian D. Cosgrove, Lexi R. Bounds, et al. Read more Research Article  |  NEUROSCIENCE Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability By Vincent Robert, Keelin O’Neil, et al. Read more Research Article  |  PHOTOSYNTHESIS Locating the missing chlorophylls f in far-red photosystem I By Giovanni Consoli, Fiazall Tufail, et al. Read more Research Article  |  IMMUNOLOGY Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4+ T cells By Masahiro Kiuchi, Masahiro Nemoto, et al. Read more Research Article  |  GENOMICS Multispecies pangenomes reveal a pervasive influence of population size on structural variation By Scott V. Edwards, Bohao Fang, et al. Read more Research Article  |  REPRODUCTION Comparative analysis of human and mouse ovaries across age By Eliza A. Gaylord, Mariko H. Foecke, et al. Read more Research Article  |  ORGANIC CHEMISTRY Three-component assembly and structure-function relationships of (–)-gukulenin A By Vaani Gupta, Zechun Wang, et al. Read more Research Article  |  QUANTUM SIMULATION Shapiro steps in strongly-interacting Fermi gases By Giulia Del Pace, Diego Hernández-Rajkov, et al. Read more Research Article  |  QUANTUM SIMULATION Observation of Shapiro steps in an ultracold atomic Josephson junction By Erik Bernhart, Marvin Röhrle, et al. Read more Research Article  |  METABOLISM NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT By Zheng Wu, Phong T. Nguyen, et al. Read more Research Article  |  METABOLISM A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis By Tuan-Anh Nguyen, Jung-Ming G. Lin, et al. Read more Research Article  |  METHANE EMISSIONS Global energy sector methane emissions estimated by using facility-level satellite observations By Dylan Jervis, Marianne Girard, et al. Read more Research Article  |  MOLECULAR BIOLOGY Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes By Ksenia Krupina, Alexander Goginashvili, et al. Read more Research Article  |  EVOLUTION Infrared radiation is an ancient pollination signal By Wendy A. Valencia-Montoya, Marjorie A. Liénard, et al. Read more Research Article  |  THERMAL MANAGEMENT Mesoporous optically clear heat insulators for sustainable building envelopes By Amit Bhardwaj, Blaise Fleury, et al. Read more Research Article  |  MINERAL PHYSICS Substantial water retained early in Earth’s deep mantle By Wenhua Lu, Ya-Nan Yang, et al. Read more Errata Erratum for the Research Article “Cryo–electron microscopy reveals hydrogen positions and water networks in photosystem II” by R. Hussein et al. Read more Errata Erratum for the Report “Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode” by J. M. Santos et al. Read more Errata Erratum for the Report “Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice” by A. Ittner et al. Read more Careers Working Life The experiment I didn’t plan By Monika Gulia-Nuss Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. 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