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Brought to you by The Noster & Science Microbiome Prize VOLUME 391 | ISSUE 6781 | 8 JAN 2026 Editorial Editorial Weathering budget cuts: Lessons from NASA By Janet Vertesi Read more News In Depth  |  Marine Science Can ecosystems recover after the deep sea is mined? By Christian Elliott Race to scoop metals from the sea floor spurs efforts to understand impacts on rare abyssal species Read more In Depth  |  Biomedicine Fake data from trial sites ruin studies, drug firms say By Charles Piller Alzheimer’s drug developer accuses companies it hired of providing “medically impossible” results Read more In Depth  |  Trump Administration NIH leadership turmoil adds to politicization concerns By Jocelyn Kaiser, Jon Cohen NIH director was prevented from reappointing institute head Read more In Depth  |  Biology Jellyfish sleep a lot like us—and for the same reasons By Jack Tamisiea Study adds to evidence that sleep likely evolved among ancient animals as a means of repairing neurons Read more In Depth  |  Global Health New conflicts erupt over key virus database By Kai Kupferschmidt GISAID, accused of “autocratic” behavior, stops providing data to SARS-CoV-2 dashboards Read more Feature The real da Vinci code By Richard Stone Scholars on a quixotic quest to identify Leonardo da Vinci’s DNA achieve a milestone Read more Feature Art historians turn to biology By Richard Stone Paint traps a rich stew of biomolecules that can reveal artworks’ history—and authenticity Read more Commentary Expert Voices Natural grasslands used for grazing livestock can mitigate climate change By Valério D. Pillar, Bruna R. Winck Read more Perspective  |  Neuroscience Making faces By Bridget M. Waller, Jamie Whitehouse Facial expressions are produced through a coordinated system of voluntary and emotional pathways Read more Perspective  |  Cancer The source of IDH-mutant gliomas By Christopher W. Mount, Mario L. Suvà Deep sequencing of human brain tissue identifies the probable cell of origin of IDH-mutant gliomas Read more Perspective  |  Neurophysiology Not just a pain in the bone By Vicki Rosen, Francesca Gori Growth factors secreted by sensory nerves promote fracture healing Read more Perspective  |  Microbiology Tree bark microbes for climate management By Vincent Gauci Microbes living in bark can process the greenhouse gases methane, hydrogen, and carbon monoxide Read more Books et al.  |  Medicine The paradox of conscientious medicine By Ronit Y. Stahl Conscientious refusers of medical care face few costs in the US; conscientious providers face many Read more Books et al.  |  Science and Society Rethinking drug use and addiction By Cassandra L. Boness A philosopher advocates for a more humane and context-informed approach Read more Letter Iran’s largest river in crisis By Hamid M. Behzad, Muhammad Arif, et al. Read more Letter Improve air quality in public transportation By Stefanos Agathokleous, Pierre Sicard, et al. Read more Letter Iran’s ancient Hyrcanian forests on fire By Milad Mousazadehgavan, Kaveh Madani Read more Analysis Policy Article  |  Drug Policy Did the illicit fentanyl trade experience a supply shock? By Kasey Vangelov, Keith Humphreys, et al. A synthesis of government and social media data suggests a disruption, possibly tied to events in China Read more Analytical Review  |  PHYSICS Data sharing helps avoid “smoking gun” claims of topological milestones By S. M. Frolov, P. Zhang, et al. Read more Research Research Highlights In Science Journals By Stella M. Hurtley, Phil Szuromi, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Caroline Ash, Sacha Vignieri, et al. Editors’ selections from the current scientific literature Read more Research Article  |  BONE BIOLOGY Mapping somatosensory afferent circuitry to bone identifies neurotrophic signals required for fracture healing By Mingxin Xu, Zhao Li, et al. Read more Research Article  |  DRUG DISCOVERY Deep contrastive learning enables genome-wide virtual screening By Yinjun Jia, Bowen Gao, et al. Read more Research Article  |  CANCER IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation By Jung Won Park, Jiehoon Kwak, et al. Read more Research Article  |  CELL ATLAS Chinese Immune Multi-Omics Atlas By Jianhua Yin, 殷建华, et al. Read more Research Article  |  MICROBIOTA Bark microbiota modulate climate-active gas fluxes in Australian forests By Pok Man Leung, Luke C. Jeffrey, et al. Read more Research Article  |  NEUROSCIENCE Ontogeny of the spinal cord dorsal horn By Robert Brian Roome, Archana Yadav, et al. Read more Research Article  |  NEUROSCIENCE Facial gestures are enacted through a cortical hierarchy of dynamic and stable codes By Geena R. Ianni, Yuriria Vázquez, et al. Read more Research Article  |  SOLAR CELLS Multivalent ligands regulate dimensional engineering for inverted perovskite solar modules By Xiaoming Chang, Yanping Liu, et al. Read more Research Article  |  COMPARATIVE COGNITION Dogs with a large vocabulary of object labels learn new labels by overhearing like 1.5-year-old infants By Shany Dror, Ádám Miklósi, et al. Read more Research Article  |  SOLAR CELLS Molecular press annealing enables robust perovskite solar cells By Jianfei Hu, Qingbin Cai, et al. Read more Research Article  |  ORGANIC CHEMISTRY Leveraging triatropic rearrangements for stereoselective skeletal reshuffling By Yuan Niu, Yu Chen, et al. Read more Research Article  |  APPLIED ECOLOGY Multispecies grasslands produce more yield from lower nitrogen inputs across a climatic gradient By James O’Malley, John A. Finn, et al. Read more Research Article  |  PLANT BIOLOGY The molecular basis of the binding and specific activation of rhizobial NodD by flavonoids By Yiting Ruan, Shangzhi Dong, et al. Read more Research Article  |  MAGNETISM Self-induced Floquet magnons in magnetic vortices By Christopher Heins, Lukas Körber, et al. Read more Research Article  |  PROKARYOTIC IMMUNITY Recurrent acquisition of nuclease-protease pairs in antiviral immunity By Owen T. Tuck, Jason J. Hu, et al. Read more Research Article  |  ORGANIC CHEMISTRY Access to four-membered cyclic sulfinamides by energy transfer catalysis By Di Zhai, Benedict A. Williams, et al. Read more Errata Erratum for the Research Article “Invasion impacts in terrestrial ecosystems: Global patterns and predictors” by M. P. Thakur et al. Read more Careers Working Life Learning to lead By Derek O’Keeffe Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. Sign up Journals Science Science Advances Science Immunology Science Robotics Science Signaling Science Translational Medicine Useful links News Careers Commentary Podcast Webinars Prizes and Awards Help Access & Subscriptions Reprints & Permissions Contact Us Follow us

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