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Brought to you by Xplorer Symposia VOLUME 391 | ISSUE 6789 | 5 MAR 2026 A family’s quest for a dementia cure: read this week’s News Feature.  Editorial Editorial Sabotaging the NSF fellowship is a blunder By H. Holden Thorp Read more News In Depth  |  Infectious Diseases ‘Truly spectacular’ drug for sleeping sickness simplifies treatment, raising hopes for eradication By Gretchen Vogel European regulators greenlight new one-dose compound that could help Africa get rid of an ancient burden Read more In Depth  |  Biomedicine Stem cell therapies ‘come of age’ with two conditional approvals in Japan By Dennis Normile Induced pluripotent stem cells could help treat diseased hearts and brains Read more In Depth  |  U.S. Science Policy AI and quantum now drive NSF grantmaking, officials say By Jeffrey Mervis Leaders acknowledge White House role in recent controversial moves Read more In Depth  |  Science Policy U.S. research agency moves to restrict foreign scientists By Robert F. Service Proposed rule at National Institute of Standards and Technology would limit lab access to a few years Read more In Depth  |  Scientific Community Why three scientists said no to Epstein By Jeffrey Mervis The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude” Read more In Depth  |  Publishing Chinese institution rejects pricey open-access fees By Jeffrey Brainard Move comes amid effort to grow the country’s own journals Read more In Depth  |  Global Health Community health project slashes new HIV infections By Jon Cohen Large study shows simplifying delivery of prevention medication and improving connections to clinics is key Read more Feature Investing in hope By Jennie Erin Smith A wealthy family fighting its own disease boosted research on a little-studied brain protein, progranulin. Can it spur new dementia treatments? Read more Commentary Expert Voices Global majority countries must embed critical minerals into AI governance By Chinasa T. Okolo Read more Perspective  |  Microbiology Soaking up destructive signals By Iana Fedorova, Joseph Bondy-Denomy A structure-based approach identifies bacteriophage proteins that block bacterial immunity Read more Perspective  |  Health and Medicine Protein therapy with self-amplifying RNA By Lien Ervijn, Niek N. Sanders Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs Read more Perspective  |  Plant Science Bound by a handshake By Moritz T. Meyer, Howard Griffiths A linker moiety built into the enzyme Rubisco in an early land plant boosts carbon assimilation Read more Perspective  |  Neurodegeneration Astrocytes engineered to fight Alzheimer’s plaques By Jake Boles, David Gate Genetically altered astrocytes reduce a cardinal pathological feature of Alzheimer’s disease Read more Perspective  |  Climatology Thirty-six solutions to stabilize Earth’s climate By Haewon McJeon, Yang Ou An updated visual assessment tool can bridge the gap between climate research and political action Read more Policy Forum  |  Data Policy Governing real-world health data as a public utility By Melissa A. Haendel, Ryan Ahern, et al. The utility model offers a framework for ethical stewardship, patient empowerment, and distributed innovation Read more Books et al.  |  Review RoundUp Science stories for young readers By Lauren Kmec, Jennie Erin Smith, et al. Read more Letter Support communities to conserve the Third Pole By Yao Fu, Xuefei Yang, et al. Read more Letter Poland: No country for PhD researchers By Alan Żukowski, Martyna Stępień Read more Letter Ease the struggle of young researchers By Vitaliy Atamaniuk Read more Research Research Highlights In Science Journals By Corinne Simonti, Phil Szuromi, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Sarah H. Ross, Cheri Sirois, et al. Editors’ selections from the current scientific literature Read more Research Article  |  CLIMATE Democratizing climate change mitigation pathways using modernized stabilization wedges By Nathan Johnson, Iain Staffell Read more Research Article  |  NEUROIMMUNOLOGY Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy By Yun Chen, Yizhou Liu, et al. Read more Research Article  |  CARDIOLOGY Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction By Kaiyue Zhang, Hongyan Tao, et al. Read more Research Article  |  PLANT DEVELOPMENT A negative feedback loop between TERMINAL FLOWER1 and LEAFY protects inflorescence indeterminacy By Tian Huang, Charles Hodgens, et al. Read more Research Article  |  SIGNAL TRANSDUCTION Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2 By Martin S. Taylor, Maggie Chen, et al. Read more Research Article  |  FOREST ECOLOGY Climate change will increase forest disturbances in Europe throughout the 21st century By Marc Grünig, Werner Rammer, et al. Read more Research Article  |  MICROBIOLOGY Structural modeling reveals phage proteins that manipulate bacterial immune signaling By Nitzan Tal, Romi Hadary, et al. Read more Research Article  |  CONSERVATION GENETICS Escaping bottlenecks: The demographic path to genetic recovery in koalas (Phascolarctos cinereus) By Collin W. Ahrens, Adam D. Miller, et al. Read more Research Article  |  ADAPTATION Multiple chromosomal inversions modulate continuous local adaptation along a steep thermal cline By Maria Akopyan, Arne Jacobs, et al. Read more Research Article  |  ORIGIN OF LIFE A small polymerase ribozyme that can synthesize itself and its complementary strand By Edoardo Gianni, Samantha L. Y. Kwok, et al. Read more Research Article  |  NEUROSCIENCE Task learning increases information redundancy of neural responses in macaque visual cortex By Shizhao Liu, Anton Pletenev, et al. Read more Research Article  |  PLANT SYMBIOSIS Nanodomain-localized formin gates symbiotic microbial entry in legume and solanaceous plants By Lijin Qiao, Heng Sun, et al. Read more Research Article  |  EVOLUTION Repeated convergent evolution of bradykinin mimics as defensive toxins By Naiqi Shi, Axel Touchard, et al. Read more Research Article  |  PHYSIOLOGY Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration By Mamta Singla, Yu Xin Wang, et al. Read more Research Article  |  THERMOELECTRICS Irregular hierarchical-porous polymer for high-performance soft thermoelectrics By Xiao Zhang, Dongyang Wang, et al. Read more Research Article  |  PHOTOSYNTHESIS An unconventional Rubisco small subunit underpins the CO2-concentrating organelle in land plants By Tanner A. Robison, Yuwei Mao, et al. Read more Careers Working Life Planting a seed By Gilberto Lopez Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. 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