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Brought to you by Science & SciLifeLab Prize for Young Scientists  VOLUME 392 | ISSUE 6796 | 23 APR 2026 A push to expand mines that use fluids to extract uranium from aquifers is raising concerns about groundwater pollution: read this week’s News Feature.  Editorial Editorial Resolving the radiation risk debate By Emily A. Caffrey, Brant A. Ulsh Read more News In Depth  |  Materials Science Experts find holes in Donut battery boasts By Mark Peplow Whistleblower alleges Finnish startup’s vaunted solid-state battery isn’t what it claims Read more In Depth  |  Geoengineering Sea ice artificially thickened, but concept may not scale By Hannah Richter First Arctic trials of climate fix show pumped seawater adds and brightens ice, but gains did not last Read more In Depth  |  Research Integrity Study finds thousands of ads promising effortless authorship By Jeffrey Brainard New investigation of ads for paper mills puts numbers to shady practice Read more In Depth  |  Infectious Diseases Malaria may cause long-term brain deficits, study shows By Gretchen Vogel Ugandan children who survived a severe infection do worse on cognitive tests many years later Read more In Depth  |  Genomics First genome loaded on a quantum computer By Catherine Offord Researchers encode the tiny hepatitis D virus in an early step toward “quantum genomics” Read more In Depth  |  Paleontology Truck-size octopuses stalked Cretaceous seas By Phie Jacobs These giants may have rivaled marine reptiles as apex predators Read more Feature Deep unease By Quentin Septer A push to expand mines that use fluids to extract uranium from aquifers is raising concerns about groundwater pollution Read more Commentary Expert Voices The impact of epigenetics on health and disability By Jackie Leach Scully Read more Perspective  |  Atmospheric Science Clouds moderate Amazon deforestation’s climate effect By Gunnar Myhre An unexpected increase in cloud cover partially reduces warming caused by carbon dioxide release Read more Perspective  |  Cancer The heart puts pressure on cancer growth By Wyatt G. Paltzer, James F. Martin Mechanical forces in the heart prevent tumor expansion in mice Read more Perspective  |  Neurodevelopment Early dynamics of the genome in Down syndrome By Tarik Haydar, Zhen Li Cell type–specific early hallmarks of Down syndrome are uncovered Read more Perspective  |  Chemistry A silver rush in organic chemistry By Radim Hrdina A silver complex catalyzes formation of carbon-nitrogen bonds in compounds of industrial interest Read more Books et al.  |  Marine Science Dark discoveries By Laura Trethewey A marine microbiologist shares the joy and dangers of exploring the deep sea Read more Books et al.  |  Science and Society Writing the rainbow By Kai Kupferschmidt Color resists simple description—that has not stopped dictionary lexicographers from trying Read more Letter The EU’s cryosphere biodiversity blind spot By Mauro Gobbi, Barbara Valle, et al. Read more Letter South Korea’s wind energy threatens flyway By Hyung-Kyu Nam, Yu-Seong Choi, et al. Read more Letter France must protect pollinators over pesticides By Bertrand Schatz, Lucas Aubouin, et al. Read more Analysis Policy Article  |  Climate Policy New demand goals for energy and climate resilience By N. Bento, A. Grubler, et al. Current climate goals, largely focused on energy supply, should be complemented by targeting demand Read more Reviews Review  |  DRUG DISCOVERY Reimagining human-centric drug development with new approach methodologies By Xuekun Wu, Matthew A. Wu, et al. Read more Research Research Highlights In Science Journals By Marc S. Lavine, L. Bryan Ray, et al. Highlights from the Science family of journals Read more Research Highlights In Other Journals By Cheri Sirois, Sarah H. Ross, et al. Editors’ selections from the current scientific literature Read more Research Article  |  CARDIOLOGY Mechanical load inhibits cancer growth in mouse and human hearts By Giulio Ciucci, Daniela Lorizio, et al. Read more Research Article  |  NEUROSCIENCE Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq By Liansheng Zhang, Qi Ma, et al. Read more Research Article  |  STRATOSPHERIC AEROSOLS An unrecognized mode of small particles in the lower stratosphere By Ming Lyu, Adam T. Ahern, et al. Read more Research Article  |  NEUROSCIENCE A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex By Celine K. Vuong, Alexis Weber, et al. Read more Research Article  |  NEUROSCIENCE Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex By Ryan D. Risgaard, Kalpana Hanthanan Arachchilage, et al. Read more Research Article  |  ENERGY STORAGE Molecular solar thermal energy storage in Dewar pyrimidone beyond 1.6 megajoules per kilogram By Han P. Q. Nguyen, Alexander J. Maertens, et al. Read more Research Article  |  PHYSIOLOGY A cell-nonautonomous heme acquisition pathway enables erythroid hemoglobinization under stress By Audrey Belot, Andrew Rock, et al. Read more Research Article  |  CARBON NANOTUBES Intercalated carbon nanotube fibers with high specific electrical conductivity By A. I. de Isidro-Gómez, V. Vassilev-Galindo, et al. Read more Research Article  |  ACTUATORS Programming touch-me-not knot topologies for rapid and diverse leaping and flying motions By Yaoye Hong, Weixuan Liu, et al. Read more Research Article  |  PALEONTOLOGY Earliest octopuses were giant top predators in Cretaceous oceans By Shin Ikegami, Jörg Mutterlose, et al. Read more Research Article  |  INORGANIC CHEMISTRY [Os(η5-B5H10)2]: A carbon-free analog of ferrocene By Stutee Mohapatra, Suvam Saha, et al. Read more Research Article  |  EVOLUTION Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load By Shreyas V. Pai, Parris T. Humphrey, et al. Read more Research Article  |  ORGANIC CHEMISTRY Chiral S(VI) platform unifies selective C–H amination of complex molecules and alkane feedstocks By Tuan Anh Trinh, Derek B. Hu, et al. Read more Research Article  |  DEFORESTATION Amazon forest loss: An all-sky biophysical top-of-atmosphere cooling feedback By Tom Dror, Graham Feingold Read more Careers Working Life When ties unravel By Jiang Yang Read more FIRST RELEASE Read accepted papers posted online ahead of journal publication View all First Release Sign up for ScienceAdviser Science’s free daily newsletter delivers exclusive reporting and analysis as well as the latest science news, commentary, and research. Sign up to delve deeper into what matters most in Science and science. 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