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Volume 219, Issue 4
December 2021
EISSN 1943-2631

Volume 219, Issue 4, December 2021

Perspectives

Genetics, Volume 219, Issue 4, December 2021, iyab162, https://doi.org/10.1093/genetics/iyab162

Lysenkoism hugely damaged biology in the USSR and served as an important example of a number of similar processes in other areas of science. New evidence has recently become available about its history. Here, Ptushenko describes the remarkable efforts of mathematicians, physicists, and chemists to reanimate and rehabilitate genetics and ‘non-Michurinist’ biology as a whole.

Investigation

Experimental Technologies and Resources

Genetics, Volume 219, Issue 4, December 2021, iyab163, https://doi.org/10.1093/genetics/iyab163
Genetics, Volume 219, Issue 4, December 2021, iyab154, https://doi.org/10.1093/genetics/iyab154

Gene Expression

Genetics, Volume 219, Issue 4, December 2021, iyab168, https://doi.org/10.1093/genetics/iyab168

Horvath, Hawe et al. examine regulators of Cdk8-dependent Gal4 activity in a screen for defects in the LTA response of gal3 yeast. They identify TORC1 components tor1 and tco89 and the downstream PP2A/Cdc55 phosphatase as regulators of Gal4. Additionally, genetic analysis indicates that mutations in hom3, which encodes aspartate kinase, produce defects in TOR signaling. These results demonstrate that regulation of Gal4 by phosphorylation is modulated by the TOR nutritional signaling pathway through the activity of PP2A/Cdc55.

Genetics, Volume 219, Issue 4, December 2021, iyab138, https://doi.org/10.1093/genetics/iyab138

In presence of functional non-additive gene action, substitution effects at quantitative trait loci change across genetic backgrounds. This is relevant for genomic prediction and assessing the role of epistasis in evolution. Legarra et al. analytically derive differences of substitution effects across two populations, showing that these differences are functions of: the magnitude of additive, dominance and additive by additive variance; the genetic distance of the populations; and their heterozygosity. They illustrate these differences with simulation and real-life examples from literature.

Genetics of Complex Traits

Genetics, Volume 219, Issue 4, December 2021, iyab150, https://doi.org/10.1093/genetics/iyab150
Genetics, Volume 219, Issue 4, December 2021, iyab160, https://doi.org/10.1093/genetics/iyab160
Genetics, Volume 219, Issue 4, December 2021, iyab165, https://doi.org/10.1093/genetics/iyab165
Genetics, Volume 219, Issue 4, December 2021, iyab151, https://doi.org/10.1093/genetics/iyab151

Molecular Genetics of Development

Genetics, Volume 219, Issue 4, December 2021, iyab172, https://doi.org/10.1093/genetics/iyab172
Genetics, Volume 219, Issue 4, December 2021, iyab135, https://doi.org/10.1093/genetics/iyab135

Population and Evolutionary Genetics

Genetics, Volume 219, Issue 4, December 2021, iyab161, https://doi.org/10.1093/genetics/iyab161
Genetics, Volume 219, Issue 4, December 2021, iyab159, https://doi.org/10.1093/genetics/iyab159

Corrigenda

Genetics, Volume 219, Issue 4, December 2021, iyab167, https://doi.org/10.1093/genetics/iyab167
Genetics, Volume 219, Issue 4, December 2021, iyab158, https://doi.org/10.1093/genetics/iyab158

Reviewer Index

Genetics, Volume 219, Issue 4, December 2021, iyab200, https://doi.org/10.1093/genetics/iyab200
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