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Volume 221, Issue 4
August 2022
EISSN 1943-2631

Volume 221, Issue 4, August 2022

Wormbook

Genetics, Volume 221, Issue 4, August 2022, iyac068, https://doi.org/10.1093/genetics/iyac068

Investigation

Cellular Genetics

Genetics, Volume 221, Issue 4, August 2022, iyac086, https://doi.org/10.1093/genetics/iyac086
Genetics, Volume 221, Issue 4, August 2022, iyac090, https://doi.org/10.1093/genetics/iyac090
Genetics, Volume 221, Issue 4, August 2022, iyac093, https://doi.org/10.1093/genetics/iyac093

Computational Resources, Software, & Databases

Genetics, Volume 221, Issue 4, August 2022, iyac088, https://doi.org/10.1093/genetics/iyac088
Genetics, Volume 221, Issue 4, August 2022, iyac085, https://doi.org/10.1093/genetics/iyac085

Gene Expression

Genetics, Volume 221, Issue 4, August 2022, iyac080, https://doi.org/10.1093/genetics/iyac080
Genetics, Volume 221, Issue 4, August 2022, iyac094, https://doi.org/10.1093/genetics/iyac094

Mutations in FMR1, which encodes RNA binding protein FMRP, lead to fragile X syndrome: the most common cause of autism spectrum disorder. Flanagan, Baradaran-Hervari et al. previously found that FMRP promotes translation initiation of large proteins in Drosophila oocytes—in contrast to its previously ascribed function as a repressor of translation elongation. By comparing ribosome profiling data and measuring steady state levels of FMRP targets, they now show that FMRP-dependent large protein translation is highly conserved in the mammalian cortex.

Genetics of Complex Traits

Genetics, Volume 221, Issue 4, August 2022, iyac091, https://doi.org/10.1093/genetics/iyac091

Genome Integrity and Transmission

Genetics, Volume 221, Issue 4, August 2022, iyac067, https://doi.org/10.1093/genetics/iyac067

Wang et al. explore 10 independent Ac::MTn transposition events, observing similar patterns of transposition activity as compared to standard Ac transposition. They identify a case of a likely MTn in the endogenous maize B73 genome and in 5 NAM founder lines, suggesting a historic occurrence of MTn transposition. They show MTn is capable of mobilizing segments of DNA long enough to include a typical full-length plant gene and could theoretically erode gene co-linearity in syntenic regions during plant genome evolution.

Genetics, Volume 221, Issue 4, August 2022, iyac092, https://doi.org/10.1093/genetics/iyac092

Neurogenetics & Behavior

Genetics, Volume 221, Issue 4, August 2022, iyac096, https://doi.org/10.1093/genetics/iyac096

Population and Evolutionary Genetics

Genetics, Volume 221, Issue 4, August 2022, iyac053, https://doi.org/10.1093/genetics/iyac053

In rapidly evolving populations, multiple beneficial and deleterious mutations are often present simultaneously in a variety of linked combinations, and natural selection cannot act on each locus individually. Thus, classical population genetic theory, which treats each mutation independently, cannot be applied. Here, Melissa et al. present a general framework for calculating statistics of genetic diversity and divergence in these rapidly evolving populations. Their work expands on previous theory, connecting disparate parameter regimes from earlier studies into a more general analysis.

Genetics, Volume 221, Issue 4, August 2022, iyac087, https://doi.org/10.1093/genetics/iyac087
Genetics, Volume 221, Issue 4, August 2022, iyac089, https://doi.org/10.1093/genetics/iyac089

Present in many taxa, gamete killers are genetic loci where one allele—the killer—enhances its transmission by destroying gametes that do not carry it. Here, Simon et al. decipher a pollen killer found in numerous crosses between Arabidopsis thaliana natural variants. They show this pollen killer acts as a poison-antidote system, where killer alleles have particularly complex and variable structures with multiple copies of the antidote gene—which evolved within the species and encodes a chimeric mitochondrial protein.

Genetics, Volume 221, Issue 4, August 2022, iyac097, https://doi.org/10.1093/genetics/iyac097

Statistical Genetics and Genomics

Genetics, Volume 221, Issue 4, August 2022, iyac095, https://doi.org/10.1093/genetics/iyac095
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