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Volume 219, Issue 3
November 2021
EISSN 1943-2631

Volume 219, Issue 3, November 2021

Investigation

Experimental Technologies and Resources

Genetics, Volume 219, Issue 3, November 2021, iyab146, https://doi.org/10.1093/genetics/iyab146

Chen, Luo, Gurav et al. present the DREaMR (Drug-on, REporter, Mutant, Rescue) system for combining a mutation, a rescue transgene, and to assess gene expression using a single insertion in the endogenous gene. They demonstrate the effectiveness of the DREaMR system using the Drosophila white and Aedes kh genes. The authors suggest that the DREaMR system can be used in other organisms in which it is possible to employ CRISPR/Cas9.

Gene Expression

Genetics, Volume 219, Issue 3, November 2021, iyab145, https://doi.org/10.1093/genetics/iyab145
Genetics, Volume 219, Issue 3, November 2021, iyab149, https://doi.org/10.1093/genetics/iyab149

Genetics of Complex Traits

Genetics, Volume 219, Issue 3, November 2021, iyab115, https://doi.org/10.1093/genetics/iyab115
Genetics, Volume 219, Issue 3, November 2021, iyab143, https://doi.org/10.1093/genetics/iyab143

Genome and Systems Biology

Genetics, Volume 219, Issue 3, November 2021, iyab140, https://doi.org/10.1093/genetics/iyab140

Genome Integrity and Transmission

Genetics, Volume 219, Issue 3, November 2021, iyab137, https://doi.org/10.1093/genetics/iyab137
Genetics, Volume 219, Issue 3, November 2021, iyab147, https://doi.org/10.1093/genetics/iyab147

In polyploid cells, copy number is not uniform throughout the genome. Underreplication causes pericentric heterochromatin and defined regions of euchromatin to have reduced copy number relative to overall ploidy. SUUR and Rif1 are key regulators of underreplication, and Rif1 is a known regulator of replication timing (RT). Das et al. take a computational approach to measure replication timing in polyploid cells. Their results demonstrate that, while Rif1 and SUUR both promote underreplication, they differentially affect RT.

Molecular Genetics of Development

Genetics, Volume 219, Issue 3, November 2021, iyab127, https://doi.org/10.1093/genetics/iyab127
Genetics, Volume 219, Issue 3, November 2021, iyab132, https://doi.org/10.1093/genetics/iyab132
Genetics, Volume 219, Issue 3, November 2021, iyab144, https://doi.org/10.1093/genetics/iyab144

Neurogenetics

Neurogenetics & Behavior

Genetics, Volume 219, Issue 3, November 2021, iyab139, https://doi.org/10.1093/genetics/iyab139

Investigation

Population and Evolutionary Genetics

Genetics, Volume 219, Issue 3, November 2021, iyab094, https://doi.org/10.1093/genetics/iyab094

Johri, Charlesworth et al. re-visit an under-appreciated result from Maruyama & Kimura (1974) pertaining to deleterious fixations resulting in selective sweep-like patterns. The authors extend theory and perform simulations to examine this phenomenon, interpreting it in the contexts of single-population polymorphism-based and between-population Fst-based scans for selection. They demonstrate that, while the effect is probably too localized to be meaningfully misleading in the former, it may be a significant source of error and false-positives in the latter

Multiparental Populations

Population and Evolutionary Genetics

Genetics, Volume 219, Issue 3, November 2021, iyab136, https://doi.org/10.1093/genetics/iyab136

Investigation

Population and Evolutionary Genetics

Genetics, Volume 219, Issue 3, November 2021, iyab148, https://doi.org/10.1093/genetics/iyab148

Genomic Prediction

Statistical Genetics and Genomics

Genetics, Volume 219, Issue 3, November 2021, iyab122, https://doi.org/10.1093/genetics/iyab122

Multiparental Populations

Statistical Genetics and Genomics

Genetics, Volume 219, Issue 3, November 2021, iyab124, https://doi.org/10.1093/genetics/iyab124
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