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Volume 220, Issue 1
January 2022
EISSN 1943-2631

Volume 220, Issue 1, January 2022

Perspectives

Genetics, Volume 220, Issue 1, January 2022, iyab185, https://doi.org/10.1093/genetics/iyab185

Review

Genetics, Volume 220, Issue 1, January 2022, iyab134, https://doi.org/10.1093/genetics/iyab134

Wormbook

Evolution and Ecology

Genetics, Volume 220, Issue 1, January 2022, iyab156, https://doi.org/10.1093/genetics/iyab156

Communications

Genetics, Volume 220, Issue 1, January 2022, iyab184, https://doi.org/10.1093/genetics/iyab184

Investigation

Cellular Genetics

Genetics, Volume 220, Issue 1, January 2022, iyab153, https://doi.org/10.1093/genetics/iyab153
Genetics, Volume 220, Issue 1, January 2022, iyab152, https://doi.org/10.1093/genetics/iyab152
Genetics, Volume 220, Issue 1, January 2022, iyab155, https://doi.org/10.1093/genetics/iyab155
Genetics, Volume 220, Issue 1, January 2022, iyab171, https://doi.org/10.1093/genetics/iyab171
Genetics, Volume 220, Issue 1, January 2022, iyab164, https://doi.org/10.1093/genetics/iyab164
Genetics, Volume 220, Issue 1, January 2022, iyab183, https://doi.org/10.1093/genetics/iyab183
Genetics, Volume 220, Issue 1, January 2022, iyab188, https://doi.org/10.1093/genetics/iyab188

Experimental Technologies and Resources

Genetics, Volume 220, Issue 1, January 2022, iyab179, https://doi.org/10.1093/genetics/iyab179

In eukaryotes, small RNA silencing pathways play fundamental roles in transposon control, which is of critical importance for genome stability. Drosophila is a leading study system for small RNA-guided transposon defense. Here, ElMaghraby, Tirian et al. present a set of genetic tools centered on transgenic RNA interference that will allow the dissection of the Piwi/piRNA pathway in the developing Drosophila ovary. This toolkit is particularly suited to study the intersection of piRNA biology and essential cellular processes.

Genetics, Volume 220, Issue 1, January 2022, iyab180, https://doi.org/10.1093/genetics/iyab180
Genetics, Volume 220, Issue 1, January 2022, iyab199, https://doi.org/10.1093/genetics/iyab199

Gene Expression

Genetics, Volume 220, Issue 1, January 2022, iyab176, https://doi.org/10.1093/genetics/iyab176

In eukaryotic protein synthesis, a preinitiation complex comprising the 40S ribosomal subunit, initiation factors, and initiator tRNAi scans the mRNA leader for an AUG codon in favorable context. The 40S protein uS5 (yeast Rps2) resides in the entry channel, but its role in start codon selection was unknown. Hinnebusch and Dong find that substituting uS5 residues near the entry channel increases discrimination against non-AUG codons and/or poor sequence context, both features of suboptimal start sites, implicating uS5/Rps2 in initiation accuracy.

Genetics of Complex Traits

Genetics, Volume 220, Issue 1, January 2022, iyab157, https://doi.org/10.1093/genetics/iyab157
Genetics, Volume 220, Issue 1, January 2022, iyab192, https://doi.org/10.1093/genetics/iyab192
Genetics, Volume 220, Issue 1, January 2022, iyab208, https://doi.org/10.1093/genetics/iyab208

Genome and Systems Biology

Genetics, Volume 220, Issue 1, January 2022, iyab196, https://doi.org/10.1093/genetics/iyab196

The expanding Cas universe continues to provide new tools for manipulating genomes in animals. Takasugi, Wang, Truong et al. evaluate and report on a panel of orthogonal CRISPR and anti-CRISPR systems in zebrafish embryos. These tools will enable sophisticated genetic screens and improve other CRISPR tools, including lineage tracing.

Genome Integrity and Transmission

Genetics, Volume 220, Issue 1, January 2022, iyab169, https://doi.org/10.1093/genetics/iyab169
Genetics, Volume 220, Issue 1, January 2022, iyab190, https://doi.org/10.1093/genetics/iyab190
Genetics, Volume 220, Issue 1, January 2022, iyab203, https://doi.org/10.1093/genetics/iyab203

Molecular Genetics of Development

Genetics, Volume 220, Issue 1, January 2022, iyab170, https://doi.org/10.1093/genetics/iyab170

Entomopathogenic nematodes (EPNs) seek and invade insect hosts and release the mutually symbiotic pathogenic bacteria they carry. Together they kill the insect, and the bacteria act as a food source for the nematode. Cao, Schwartz, Tan, and Sternberg report development of the EPN Steinernema hermaphroditum, which is consistently hermaphroditic through self-fertilization, as an experimental genetic system for the study of symbiosis and parasitism. They describe the sex determination of this species and present efficient methods for in vitro culture, cryopreservation, and mutagenesis.

Genetics, Volume 220, Issue 1, January 2022, iyab177, https://doi.org/10.1093/genetics/iyab177

Degradation of the Smaug RNA-binding protein is essential for an orderly maternal-to-zygotic transition (MZT) and requires zygotic transcription. Cao et al. show that the F-box protein Bard is expressed in a narrow time window at the end of the MZT. Upon Bard expression, an SCF E3 ubiquitin ligase complex binds to Smaug, and Smaug is degraded. Loss of Bard results in failure to degrade Smaug, meaning Bard serves as a zygotic timer for Smaug clearance and an orderly MZT.

Genetics, Volume 220, Issue 1, January 2022, iyab191, https://doi.org/10.1093/genetics/iyab191
Genetics, Volume 220, Issue 1, January 2022, iyab202, https://doi.org/10.1093/genetics/iyab202
Genetics, Volume 220, Issue 1, January 2022, iyab209, https://doi.org/10.1093/genetics/iyab209

Neurogenetics & Behavior

Genetics, Volume 220, Issue 1, January 2022, iyab175, https://doi.org/10.1093/genetics/iyab175
Genetics, Volume 220, Issue 1, January 2022, iyab186, https://doi.org/10.1093/genetics/iyab186
Genetics, Volume 220, Issue 1, January 2022, iyab198, https://doi.org/10.1093/genetics/iyab198

Population and Evolutionary Genetics

Genetics, Volume 220, Issue 1, January 2022, iyab142, https://doi.org/10.1093/genetics/iyab142
Genetics, Volume 220, Issue 1, January 2022, iyab166, https://doi.org/10.1093/genetics/iyab166
Genetics, Volume 220, Issue 1, January 2022, iyab189, https://doi.org/10.1093/genetics/iyab189

Brown and Kelly perform a genome-wide association study on the transcriptome of yellow monkeyflower using previously sequenced inbred lines. They find a striking difference in the minor allele frequency spectrum of SNPs affecting gene expression in cis vs. in trans. The authors show that gene co-expression modules can predict fitness-related life-history phenotypes that experience fitness tradeoffs in field studies.

Genetics, Volume 220, Issue 1, January 2022, iyab204, https://doi.org/10.1093/genetics/iyab204
Genetics, Volume 220, Issue 1, January 2022, iyab205, https://doi.org/10.1093/genetics/iyab205
Genetics, Volume 220, Issue 1, January 2022, iyab207, https://doi.org/10.1093/genetics/iyab207

Statistical Genetics and Genomics

Genetics, Volume 220, Issue 1, January 2022, iyab090, https://doi.org/10.1093/genetics/iyab090
Genetics, Volume 220, Issue 1, January 2022, iyab141, https://doi.org/10.1093/genetics/iyab141

Bijma, Hulst, and De Jong develop a quantitative genetic theory of the host population for both R0 and the prevalence of infectious diseases, showing that most of the heritable variation for endemic prevalence is hidden due to Indirect Genetic Effects resulting from transmission dynamics of the infection. Consequently, genetic variation in the host population and response to selection for the prevalence are large and increase strongly when prevalence decreases. In contrast to classical theory, genetic selection can eradicate infectious diseases.

Corrigendum

Genetics, Volume 220, Issue 1, January 2022, iyab181, https://doi.org/10.1093/genetics/iyab181

Erratum

Genetics, Volume 220, Issue 1, January 2022, iyab128, https://doi.org/10.1093/genetics/iyab128
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