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New Articles in PLOS Genetics

PUBLISHED: June 01, 2022 to June 30, 2022

Research Articles

Enhanced transcriptional heterogeneity mediated by NF-kappa B super-enhancers

Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice

Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae

Generation and characterization of Ccdc28b mutant mice links the Bardet-Biedl associated gene with mild social behavioral phenotypes

An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency

Dynamics of Salmonella enterica and antimicrobial resistance in the Brazilian poultry industry and global impacts on public health

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program

Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex

Using genetic variation to disentangle the complex relationship between food intake and health outcomes

Single strand gap repair: The presynaptic phase plays a pivotal role in modulating lesion tolerance pathways

Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region

The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline

Regulation of HLA class I expression by non-coding gene variations

Widespread phages of endosymbionts: Phage WO genomics and the proposed taxonomic classification of Symbioviridae

Empirical estimates of the mutation rate for an alphabaculovirus

A role for the mitotic proteins Bub3 and BuGZ in transcriptional regulation of catalase-3 expression

The phospho-docking protein 14-3-3 regulates microtubule-associated proteins in oocytes including the chromosomal passenger Borealin

Tissue-specific inhibition of protein sumoylation uncovers diverse SUMO functions during C. elegans vulval development

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila

Network assisted analysis of de novo variants using protein-protein interaction information identified 46 candidate genes for congenital heart disease

OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans

Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model

Single cell transcriptomics reveals dysregulated cellular and molecular networks in a fragile X syndrome model

Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss

Sex-specific variation in R-loop formation in Drosophila melanogaster

Krüppel-like factor 15 integrated autophagy and gluconeogenesis to maintain glucose homeostasis under 20-hydroxyecdysone regulation

Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM

Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice

High sorbic acid resistance of Penicillium roqueforti is mediated by the SORBUS gene cluster

The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution

Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells

Combined analyses of RNA-sequence and Hi-C along with GWAS loci'A novel approach to dissect keloid disorder genetic mechanism

Genetic epidemiology of blood type, disease and trait variants, and genome-wide genetic diversity in over 11,000 domestic cats

Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells

EPIC: Inferring relevant cell types for complex traits by integrating genome-wide association studies and single-cell RNA sequencing

Repeated truncation of a modular antimicrobial peptide gene for neural context

Intragenomic variation in non-adaptive nucleotide biases causes underestimation of selection on synonymous codon usage

Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency

The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1

P450 gene duplication and divergence led to the evolution of dual novel functions and insecticide cross-resistance in the brown planthopper Nilaparvata lugens

Comprehensive analysis of cis- and trans-acting factors affecting ectopic Break-Induced Replication

Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence

A MademoiseLLE domain binding platform links the key RNA transporter to endosomes

Control of nitrogen fixation and ammonia excretion in Azorhizobium caulinodans

A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations

Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes

Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2

Old genes in new places: A taxon-rich analysis of interdomain lateral gene transfer events

Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals

Selective role of the DNA helicase Mcm5 in BMP retrograde signaling during Drosophila neuronal differentiation

Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery

Divergent signaling requirements of dSARM in injury-induced degeneration and developmental glial phagocytosis

Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity

Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth

The AalNix3&4 isoform is required and sufficient to convert Aedes albopictus females into males

Juvenile hormone promotes paracellular transport of yolk proteins via remodeling zonula adherens at tricellular junctions in the follicular epithelium

Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice

A bistable prokaryotic differentiation system underlying development of conjugative transfer competence

Two duplicated gsdf homeologs cooperatively regulate male differentiation by inhibiting cyp19a1a transcription in a hexaploid fish

The essential Rhodobacter sphaeroides CenKR two-component system regulates cell division and envelope biosynthesis

PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy

Integration of multidimensional splicing data and GWAS summary statistics for risk gene discovery


Correction: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components

Correction: MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity


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