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Current Issue of SCIENCE


Contents | Science 374, 6574
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COVER Artificial intelligence algorithms can now churn out predictions for the three-dimensional shapes of proteins, key to their function, with a precision matching that of painstaking laboratory techniques. The programs, and the blizzard of protein structures they have revealed, are Science’s 2021 Breakthrough of the Year.

Illustration: V. Altounian/Science; Data: I. R. Humphreys et al., Science 374, eabm4805 (2021); DOI: 10.1126/science.abm4805

Science

  • Volume 374|
  • Issue 6574|
  • 17 Dec 2021

COVER Artificial intelligence algorithms can now churn out predictions for the three-dimensional shapes of proteins, key to their function, with a precision matching that of painstaking laboratory techniques. The programs, and the blizzard of protein structures they have revealed, are Science’s 2021 Breakthrough of the Year.

Illustration: V. Altounian/Science; Data: I. R. Humphreys et al., Science 374, eabm4805 (2021); DOI: 10.1126/science.abm4805

Special issue

2021 Breakthrough of the Year

News

    BY
    • Robert F. Service
  • : 1426-1427
  • FULL ACCESS
AI-powered predictions reveal the shapes of proteins by the thousands
    BY
    • Elizabeth Pennisi
    • Daniel Clery
    • Jennifer Couzin-Frankel
    • Kelly Servick
    • Jon Cohen
    • Paul Voosen
    • Adrian Cho
    • Jocelyn Kaiser
    • Mitch Leslie
  • : 1428-1433
  • FULL ACCESS
    BY
    • Kai Kupferschmidt
  • : 1434-1435
  • FULL ACCESS
By total doses delivered, the COVID-19 vaccine rollout was a spectacular success. By other measures, it went tragically awry
    BY
    • Paul Voosen
    • Kelly Servick
    • Cathleen O’Grady
  • : 1436-1436
  • FULL ACCESS
What went wrong in the world of science

Editorial

    BY
    • H. Holden Thorp
  • : 1415-1415
  • FULL ACCESS

In Brief

    BY
    • : 1418-1419
    • FULL ACCESS
      BY
      • Paul Voosen
    • : 1420-1421
    • FULL ACCESS
    Breakup of shelf holding back Thwaites Glacier will ramp up sea level rise
      BY
      • Kai Kupferschmidt
    • : 1421-1422
    • FULL ACCESS
    Another major pandemic wave seems inevitable. The big question is how much severe disease it will bring
      BY
      • Fred Pearce
    • : 1422-1423
    • FULL ACCESS
    Sterilization, contraceptives push fertility rate down to two children per woman
      BY
      • Warren Cornwall
    • : 1424-1424
    • FULL ACCESS
    Panel urges large tests of iron-triggered plankton blooms
      BY
      • Mitch Leslie
    • : 1425-1425
    • FULL ACCESS
    Unexpected protection may result from wayward blood cells that enter brain

      BY
      • Angela Hessler
    • : 1526-1526
    • FULL ACCESS

    Letters

      BY
      • Lesley Scott
      • Nei-yuan Hsiao
      • Sikhuline Moyo
      • Lavanya Singh
      • Houriiyah Tegally
      • Graeme Dor
      • Piet Maes
      • Oliver G. Pybus
      • Moritz U. G. Kraemer
      • Elizaveta Semenova
      • Samir Bhatt
      • Seth Flaxman
      • Nuno R. Faria
      • Tulio de Oliveira
    • : 1454-1455
    • Open Access
      BY
      • Tanya J. Gallegos
    • : 1455-1455
    • FULL ACCESS
      BY
      • Janet G. Hering
      • Roberta Croce
      • Beate I. Escher
      • Anne E. Magurran
      • Beatriz Noheda
    • : 1455-1456
    • FULL ACCESS
      BY
      • : 1456-1456
      • FULL ACCESS

      Books et al.

        BY
        • Ashley Huderson
      • : 1451-1451
      • FULL ACCESS
      Inconsistent and agenda-driven K–12 curricula leave US citizens ill-equipped to confront environmental problems
        BY
        • Daniel D. Richter
      • : 1452-1452
      • FULL ACCESS
      Could a controversial carbon storage plan help restore degraded lands?
      • : 1452-1452
      • FULL ACCESS

      Policy Forum

        BY
        • Tania Cernuschi
        • Stefano Malvolti
        • Matthew Downham
        • Dominique Maugeais
        • David Robinson
        • Alejandro Cravioto
      • : 1438-1441
      • FULL ACCESS
      Vaccine production is quadrupling rapidly, creating supply chain challenges

      Perspectives

        BY
        • Nico Eisenhauer
        • Alexandra Weigelt
      • : 1442-1443
      • FULL ACCESS
      A large-scale experimental facility reveals tropical rainforest responses to drought
        BY
        • Filip Bošković
        • Ulrich F. Keyser
      • : 1443-1444
      • FULL ACCESS
      Nanopore rereading of single proteins opens a pathway to next-generation proteomics
        BY
        • Xia Hong
      • : 1445-1446
      • FULL ACCESS
      An oxygen-free polar perovskite offers several advantages over perovskite oxides
        BY
        • Anne M. van der Leun
        • Ton N. Schumacher
      • : 1446-1447
      • FULL ACCESS
      Intratumoral T cell composition is relevant for disease outcome across tumor types
        BY
        • P. J. Hore
      • : 1447-1448
      • FULL ACCESS
      Laser spectroscopy reveals spin quantum beats in electron transfer reactions
        BY
        • Erik Keimpema
        • Vincenzo Di Marzo
        • Tibor Harkany
      • : 1449-1450
      • FULL ACCESS
      Mechanistic insights into cannabinoid signaling could improve therapeutic applications

      expression of concern

        BY
        • : 1454-1454
        • FULL ACCESS

        In Other Journals

          BY
          • Stella M. Hurtley
          • Caroline Ash
          • Sacha Vignieri
          • Andrew M. Sugden
          • Keith T. Smith
          • Marc S. Lavine
          • Melissa McCartney
        • : 1459-1460
        • FULL ACCESS
        Editors’ selections from the current scientific literature

        In Science Journals

          BY
          • Brent Grocholski
          • Peter Stern
          • Jelena Stajic
          • Sacha Vignieri
          • Thomas P. Burris
          • Ian S. Osborne
          • Ifor Williams
          • Yury Suleymanov
          • Andrew M. Sugden
          • Di Jiang
          • Phil Szuromi
          • Catherine A. Charneski
          • Wei Wong
          • Gemma Alderton
          • Laura M. Zahn
          • Caroline Ash
        • : 1458-1460
        • FULL ACCESS
        Highlights from the Science family of journals

        Reports

          BY
          • J. Randall
          • C. E. Bradley
          • F. V. van der Gronden
          • A. Galicia
          • M. H. Abobeih
          • M. Markham
          • D. J. Twitchen
          • F. Machado
          • N. Y. Yao
          • T. H. Taminiau
        • : 1474-1478
        • FULL ACCESS
        A programmable, spin-based quantum simulator was used to realize a many-body-localized discrete time crystal.
          BY
          • Xiao Mi
          • Pedram Roushan
          • Chris Quintana
          • Salvatore Mandrà
          • Jeffrey Marshall
          • Charles Neill
          • Frank Arute
          • Kunal Arya
          • Juan Atalaya
          • Ryan Babbush
          • Joseph C. Bardin
          • Rami Barends
          • Joao Basso
          • Andreas Bengtsson
          • Sergio Boixo
          • Alexandre Bourassa
          • Michael Broughton
          • Bob B. Buckley
          • David A. Buell
          • Brian Burkett
          • Nicholas Bushnell
          • Zijun Chen
          • Benjamin Chiaro
          • Roberto Collins
          • William Courtney
          • Sean Demura
          • Alan R. Derk
          • Andrew Dunsworth
          • Daniel Eppens
          • Catherine Erickson
          • Edward Farhi
          • Austin G. Fowler
          • Brooks Foxen
          • Craig Gidney
          • Marissa Giustina
          • Jonathan A. Gross
          • Matthew P. Harrigan
          • Sean D. Harrington
          • Jeremy Hilton
          • Alan Ho
          • Sabrina Hong
          • Trent Huang
          • William J. Huggins
          • L. B. Ioffe
          • Sergei V. Isakov
          • Evan Jeffrey
          • Zhang Jiang
          • Cody Jones
          • Dvir Kafri
          • Julian Kelly
          • Seon Kim
          • Alexei Kitaev
          • Paul V. Klimov
          • Alexander N. Korotkov
          • Fedor Kostritsa
          • David Landhuis
          • Pavel Laptev
          • Erik Lucero
          • Orion Martin
          • Jarrod R. McClean
          • Trevor McCourt
          • Matt McEwen
          • Anthony Megrant
          • Kevin C. Miao
          • Masoud Mohseni
          • Shirin Montazeri
          • Wojciech Mruczkiewicz
          • Josh Mutus
          • Ofer Naaman
          • Matthew Neeley
          • Michael Newman
          • Murphy Yuezhen Niu
          • Thomas E. O’Brien
          • Alex Opremcak
          • Eric Ostby
          • Balint Pato
          • Andre Petukhov
          • Nicholas Redd
          • Nicholas C. Rubin
          • Daniel Sank
          • Kevin J. Satzinger
          • Vladimir Shvarts
          • Doug Strain
          • Marco Szalay
          • Matthew D. Trevithick
          • Benjamin Villalonga
          • Theodore White
          • Z. Jamie Yao
          • Ping Yeh
          • Adam Zalcman
          • Hartmut Neven
          • Igor Aleiner
          • Kostyantyn Kechedzhi
          • Vadim Smelyanskiy
          • Yu Chen
        • : 1479-1483
        • FULL ACCESS
        Operator spreading and entanglement were studied in a 53-qubit quantum processor.
          BY
          • Jacob Repicky
          • Po-Kuan Wu
          • Tao Liu
          • Joseph P. Corbett
          • Tiancong Zhu
          • Shuyu Cheng
          • Adam S. Ahmed
          • N. Takeuchi
          • J. Guerrero-Sanchez
          • Mohit Randeria
          • Roland K. Kawakami
          • Jay A. Gupta
        • : 1484-1487
        • FULL ACCESS
        Spin-polarized scanning tunneling microscopy was used to reveal topological magnetic patterns in a thin film.
          BY
          • Kevin R. Talley
          • Craig L. Perkins
          • David R. Diercks
          • Geoff L. Brennecka
          • Andriy Zakutayev
        • : 1488-1491
        • FULL ACCESS
        A lanthanum tungsten nitride perovskite has piezoelectric properties attractive for a variety of applications.
          BY
          • Jordan S. Farrell
          • Matthew Lovett-Barron
          • Peter M. Klein
          • Fraser T. Sparks
          • Tilo Gschwind
          • Anna L. Ortiz
          • Biafra Ahanonu
          • Susanna Bradbury
          • Satoshi Terada
          • Mikko Oijala
          • Ernie Hwaun
          • Barna Dudok
          • Gergely Szabo
          • Mark J. Schnitzer
          • Karl Deisseroth
          • Attila Losonczy
          • Ivan Soltesz
        • : 1492-1496
        • FULL ACCESS
        The activity of neurons in the supramamillary nucleus of the rodent hypothalamus is highly correlated with the speed of movement.
          BY
          • Shane C. Campbell-Staton
          • Reena H. Walker
          • Savannah A. Rogers
          • Jason De León
          • Hannah Landecker
          • Warren Porter
          • Paul D. Mathewson
          • Ryan A. Long
        • : 1496-1500
        • FULL ACCESS
        Stresses linked to dehydration explain patterns of mortality among human migrants in the Sonoran Desert.
          BY
          • Shancheng Wang
          • Tengyao Jiang
          • Yun Meng
          • Ronggui Yang
          • Gang Tan
          • Yi Long
        • : 1501-1504
        • FULL ACCESS
        Tungsten-doped vanadium dioxide allows fabrications of windows that might be cooler in the summer and warmer in the winter.
          BY
          • Kechao Tang
          • Kaichen Dong
          • Jiachen Li
          • Madeleine P. Gordon
          • Finnegan G. Reichertz
          • Hyungjin Kim
          • Yoonsoo Rho
          • Qingjun Wang
          • Chang-Yu Lin
          • Costas P. Grigoropoulos
          • Ali Javey
          • Jeffrey J. Urban
          • Jie Yao
          • Ronnen Levinson
          • Junqiao Wu
        • : 1504-1509
        • FULL ACCESS
        A smart radiative coating automatically switches thermal radiation power in response to ambient temperature.
          BY
          • Henry Brinkerhoff
          • Albert S. W. Kang
          • Jingqian Liu
          • Aleksei Aksimentiev
          • Cees Dekker
        • : 1509-1513
        • FULL ACCESS
        A nanopore-based approach was developed for reading individual peptides with sensitivity to single-amino-acid substitutions.
          BY
          • Christiane Werner
          • Laura K. Meredith
          • S. Nemiah Ladd
          • Johannes Ingrisch
          • Angelika Kübert
          • Joost van Haren
          • Michael Bahn
          • Kinzie Bailey
          • Ines Bamberger
          • Matthias Beyer
          • Daniel Blomdahl
          • Joseph Byron
          • Erik Daber
          • Jason Deleeuw
          • Michaela A. Dippold
          • Jane Fudyma
          • Juliana Gil-Loaiza
          • Linnea K. Honeker
          • Jia Hu
          • Jianbei Huang
          • Thomas Klüpfel
          • Jordan Krechmer
          • Jürgen Kreuzwieser
          • Kathrin Kühnhammer
          • Marco M. Lehmann
          • Kathiravan Meeran
          • Pawel K. Misztal
          • Wei-Ren Ng
          • Eva Pfannerstill
          • Giovanni Pugliese
          • Gemma Purser
          • Joseph Roscioli
          • Lingling Shi
          • Malak Tfaily
          • Jonathan Williams
        • : 1514-1518
        • FULL ACCESS
        Plant functional adaptations, water use strategies, and soil interactions determine drought impact and recovery in forests.

        Research Articles

          BY
          • Liangtao Zheng
          • Shishang Qin
          • Wen Si
          • Anqiang Wang
          • Baocai Xing
          • Ranran Gao
          • Xianwen Ren
          • Li Wang
          • Xiaojiang Wu
          • Ji Zhang
          • Nan Wu
          • Ning Zhang
          • Hong Zheng
          • Hanqiang Ouyang
          • Keyuan Chen
          • Zhaode Bu
          • Xueda Hu
          • Jiafu Ji
          • Zemin Zhang
        • FULL ACCESS
        Single-cell RNA sequencing of cancer-associated T cells elucidates links between immune cell types and tumor characteristics.
          BY
          • Jouni Sirén
          • Jean Monlong
          • Xian Chang
          • Adam M. Novak
          • Jordan M. Eizenga
          • Charles Markello
          • Jonas A. Sibbesen
          • Glenn Hickey
          • Pi-Chuan Chang
          • Andrew Carroll
          • Namrata Gupta
          • Stacey Gabriel
          • Thomas W. Blackwell
          • Aakrosh Ratan
          • Kent D. Taylor
          • Stephen S. Rich
          • Jerome I. Rotter
          • David Haussler
          • Erik Garrison
          • Benedict Paten
        • FULL ACCESS
        A mapping algorithm named Giraffe has been developed to allow mapping of short-read sequences for thousands of genomes.
          BY
          • Paul Elliott
          • David Haw
          • Haowei Wang
          • Oliver Eales
          • Caroline E. Walters
          • Kylie E. C. Ainslie
          • Christina Atchison
          • Claudio Fronterre
          • Peter J. Diggle
          • Andrew J. Page
          • Alexander J. Trotter
          • Sophie J. Prosolek
          • The COVID-19 Genomics UK (COG-UK) Consortium
          • Deborah Ashby
          • Christl A. Donnelly
          • Wendy Barclay
          • Graham Taylor
          • Graham Cooke
          • Helen Ward
          • Ara Darzi
          • Steven Riley
        • Open Access
        The SARS-CoV-2 Delta variant increased exponentially in the United Kingdom driven by infection in the young, not yet vaccinated, population.
          BY
          • Jian-Bin Lin
          • Tai T. T. Nguyen
          • Ramanathan Vaidhyanathan
          • Jake Burner
          • Jared M. Taylor
          • Hana Durekova
          • Farid Akhtar
          • Roger K. Mah
          • Omid Ghaffari-Nik
          • Stefan Marx
          • Nicholas Fylstra
          • Simon S. Iremonger
          • Karl W. Dawson
          • Partha Sarkar
          • Pierre Hovington
          • Arvind Rajendran
          • Tom K. Woo
          • George K. H. Shimizu
        • : 1464-1469
        • FULL ACCESS
        A metal-organic framework captures CO2 with high capacity and selectivity over steam with only a modest regeneration penalty.
          BY
          • David Mims
          • Jonathan Herpich
          • Nikita N. Lukzen
          • Ulrich E. Steiner
          • Christoph Lambert
        • : 1470-1474
        • FULL ACCESS
        Spin interconversion quantum beats (oscillations) in a photo-induced radical pair are monitored by an all-optical method.

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