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Current Issue of SCIENCE


Contents | Science 374, 6575
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COVER Artist's rendering of the path from a positive COVID-19 test to a potential drug treatment. Researchers have developed a drug to target SARS-CoV-2, the virus that causes COVID-19. The molecule, known as PF-07321332, blocks the virus’s main protease, an enzyme critical to its replication. The molecule can be delivered in pill form, which may lead to a COVID-19 treatment that can be used outside of a hospital setting. See page 1586.

Illustration: Jason Solo/The Jacky Winter Group

Science

  • Volume 374|
  • Issue 6575|
  • 24 Dec 2021

COVER Artist's rendering of the path from a positive COVID-19 test to a potential drug treatment. Researchers have developed a drug to target SARS-CoV-2, the virus that causes COVID-19. The molecule, known as PF-07321332, blocks the virus’s main protease, an enzyme critical to its replication. The molecule can be delivered in pill form, which may lead to a COVID-19 treatment that can be used outside of a hospital setting. See page 1586.

Illustration: Jason Solo/The Jacky Winter Group

Editorial

    BY
    • H. Holden Thorp
  • : 1537-1537
  • FULL ACCESS

News

In Brief
    BY
    • Jeffrey Brainard
  • : 1540-1542
  • FULL ACCESS
In Depth
    BY
    • Gretchen Vogel
    • Kai Kupferschmidt
  • : 1543-1544
  • FULL ACCESS
Some data hint the new variant may be milder—but most scientists reserve judgment
    BY
    • Jon Cohen
  • : 1544-1545
  • FULL ACCESS
Current boosters, variant-specific shots, and universal coronavirus vaccines all have fans
    BY
    • Jon Cohen
  • : 1546-1546
  • FULL ACCESS
Novavax vaccine authorization bolsters COVAX’s optimistic new supply forecast
    BY
    • Jocelyn Kaiser
  • : 1547-1547
  • FULL ACCESS
Geneticist’s 12-year tenure marked by funding increases, new initiatives, and battling the COVID-19 pandemic
    BY
    • Daniel Clery
  • : 1548-1548
  • FULL ACCESS
Study 16 years in the making shows how gravity distorts orbits and slows down photons
    BY
    • Ann Gibbons
  • : 1549-1549
  • FULL ACCESS
Ancient DNA reveals 3000-year-old influx of people from France to Britain
Feature
    BY
    • Sofia Moutinho
  • : 1550-1553
  • FULL ACCESS
A rainforest expedition brings COVID-19 vaccines to some of Brazil’s most remote and vulnerable groups

Insights

Perspectives
    BY
    • Lene Liebe Delsett
    • Nicholas D. Pyenson
  • : 1554-1555
  • FULL ACCESS
A whale-sized ichthyosaur shows how fast these reptiles evolved
    BY
    • Dominik M. Juraschek
    • Prineha Narang
  • : 1555-1556
  • FULL ACCESS
Strong magnon-phonon coupling may help develop superfast optical drives
    BY
    • Bryan A. Johnson
    • Vineet D. Menachery
  • : 1557-1558
  • FULL ACCESS
Virus-like particles offer a new way to investigate genetic variation in SARS-CoV-2
    BY
    • Yang Zhang
    • Paweł Dydio
  • : 1558-1559
  • FULL ACCESS
Cytochromes P450 were engineered to conduct abiotic, stereoselective radical reactions
    BY
    • Tommaso Vicanolo
    • Andrés Hidalgo
  • : 1559-1560
  • FULL ACCESS
Fibrin deposits in the oral mucosa trigger neutrophil activation and bone destruction
    BY
    • Ravindra K. Gupta
    • Eric J. Topol
  • : 1561-1562
  • FULL ACCESS
Vaccine efficacy wanes over time but can be fully restored with a booster dose
Policy Forum
    BY
    • Bradley W. Biggs
    • Hal S. Alper
    • Brian F. Pfleger
    • Keith E. J. Tyo
    • Christine N. S. Santos
    • Parayil Kumaran Ajikumar
    • Gregory Stephanopoulos
  • : 1563-1565
  • FULL ACCESS
Commercial-scale research translation has been muted
Books et al.
    BY
    • Riley Black
  • : 1566-1566
  • FULL ACCESS
An otherwise solid dinosaur primer does little to convey the changing face of the field
    BY
    • Robert S. Krauss
  • : 1567-1567
  • FULL ACCESS
A new film documents the fraught first days of the COVID-19 pandemic in New York City
  • : 1567-1567
  • FULL ACCESS
Letters
    BY
    • Pablo I. Plaza
    • Sergio. A. Lambertucci
  • : 1568-1568
  • FULL ACCESS
    BY
    • Miriam Miyagi
    • Eartha Mae Guthman
    • Simón(e) Dow-Kuang Sun
  • : 1568-1569
  • FULL ACCESS
    BY
    • Lucas Ferrante
    • Philip M. Fearnside
  • : 1569-1569
  • FULL ACCESS

Research

In Science Journals
    BY
    • Di Jiang
    • Phil Szuromi
    • John F. Foley
    • Valda Vinson
    • Jake Yeston
    • Priscilla N. Kelly
    • Catherine A. Charneski
    • Gemma Alderton
    • Seth Thomas Scanlon
    • Sacha Vignieri
    • Pamela J. Hines
    • Ian S. Osborne
    • Michael A. Funk
    • Hannah M. Isles
  • : 1572-1574
  • FULL ACCESS
Highlights from the Science family of journals
In Other Journals
    BY
    • Andrew M. Sugden
    • Seth Thomas Scanlon
    • Beverly A. Purnell
    • Gemma Alderton
    • Phil Szuromi
    • Yury Suleymanov
    • Yuen Yiu
  • : 1573-1574
  • FULL ACCESS
Editors’ selections from the current scientific literature
Research Articles
    BY
    • Pawel Roszak
    • Jung-ok Heo
    • Bernhard Blob
    • Koichi Toyokura
    • Yuki Sugiyama
    • Maria Angels de Luis Balaguer
    • Winnie W. Y. Lau
    • Fiona Hamey
    • Jacopo Cirrone
    • Ewelina Madej
    • Alida M. Bouatta
    • Xin Wang
    • Marjorie Guichard
    • Robertas Ursache
    • Hugo Tavares
    • Kevin Verstaen
    • Jos Wendrich
    • Charles W. Melnyk
    • Yoshihisa Oda
    • Dennis Shasha
    • Sebastian E. Ahnert
    • Yvan Saeys
    • Bert De Rybel
    • Renze Heidstra
    • Ben Scheres
    • Guido Grossmann
    • Ari Pekka Mähönen
    • Philipp Denninger
    • Berthold Göttgens
    • Rosangela Sozzani
    • Kenneth D. Birnbaum
    • Yrjö Helariutta
  • FULL ACCESS
Single-cell analysis shows how the generalized root meristem builds a range of specialized tissues.
    BY
    • Thomas S. Kraft
    • Vivek V. Venkataraman
    • Ian J. Wallace
    • Alyssa N. Crittenden
    • Nicholas B. Holowka
    • Jonathan Stieglitz
    • Jacob Harris
    • David A. Raichlen
    • Brian Wood
    • Michael Gurven
    • Herman Pontzer
  • FULL ACCESS
Human hunter-gatherers and subsistence farmers spend more energy but less time on subsistence than other great apes.
    BY
    • P. Martin Sander
    • Eva Maria Griebeler
    • Nicole Klein
    • Jorge Velez Juarbe
    • Tanja Wintrich
    • Liam J. Revell
    • Lars Schmitz
  • FULL ACCESS
A 244-million-year-old fossil of a massive ichthyosaur suggests that there was a burst of gigantism in the group after the Permian extinction.
    BY
    • Lakmali M. Silva
    • Andrew D. Doyle
    • Teresa Greenwell-Wild
    • Nicolas Dutzan
    • Collin L. Tran
    • Loreto Abusleme
    • Lih Jiin Juang
    • Jerry Leung
    • Elizabeth M. Chun
    • Andrew G. Lum
    • Cary S. Agler
    • Carlos E. Zuazo
    • Megan Sibree
    • Priyam Jani
    • Vardit Kram
    • Daniel Martin
    • Kevin Moss
    • Michail S. Lionakis
    • Francis J. Castellino
    • Christian J. Kastrup
    • Matthew J. Flick
    • Kimon Divaris
    • Thomas H. Bugge
    • Niki M. Moutsopoulos
  • FULL ACCESS
Fibrin can activate neutrophils in the oral mucosa and promote periodontal disease.
    BY
    • Kun Huang
    • Xiao-Xian Wu
    • Cheng-Li Fang
    • Zhou-Geng Xu
    • Hong-Wei Zhang
    • Jian Gao
    • Chuan-Miao Zhou
    • Lin-Lin You
    • Zhan-Xi Gu
    • Wen-Hui Mu
    • Yu Feng
    • Jia-Wei Wang
    • Yu Zhang
  • : 1579-1586
  • FULL ACCESS
RNA polymerase catalyzes double-stranded RNA synthesis.
    BY
    • Dafydd R. Owen
    • Charlotte M. N. Allerton
    • Annaliesa S. Anderson
    • Lisa Aschenbrenner
    • Melissa Avery
    • Simon Berritt
    • Britton Boras
    • Rhonda D. Cardin
    • Anthony Carlo
    • Karen J. Coffman
    • Alyssa Dantonio
    • Li Di
    • Heather Eng
    • RoseAnn Ferre
    • Ketan S. Gajiwala
    • Scott A. Gibson
    • Samantha E. Greasley
    • Brett L. Hurst
    • Eugene P. Kadar
    • Amit S. Kalgutkar
    • Jack C. Lee
    • Jisun Lee
    • Wei Liu
    • Stephen W. Mason
    • Stephen Noell
    • Jonathan J. Novak
    • R. Scott Obach
    • Kevin Ogilvie
    • Nandini C. Patel
    • Martin Pettersson
    • Devendra K. Rai
    • Matthew R. Reese
    • Matthew F. Sammons
    • Jean G. Sathish
    • Ravi Shankar P. Singh
    • Claire M. Steppan
    • Al E. Stewart
    • Jamison B. Tuttle
    • Lawrence Updyke
    • Patrick R. Verhoest
    • Liuqing Wei
    • Qingyi Yang
    • Yuao Zhu
  • : 1586-1593
  • Open Access
PF-07321332 is an orally active, small-molecule inhibitor of the SARS-CoV-2 main protease that is in clinical trials for the treatment of COVID-19.
    BY
    • Katja Li
    • Suzanne Z. Andersen
    • Michael J. Statt
    • Mattia Saccoccio
    • Vanessa J. Bukas
    • Kevin Krempl
    • Rokas Sažinas
    • Jakob B. Pedersen
    • Vahid Shadravan
    • Yuanyuan Zhou
    • Debasish Chakraborty
    • Jakob Kibsgaard
    • Peter C. K. Vesborg
    • Jens K. Nørskov
    • Ib Chorkendorff
  • : 1593-1597
  • FULL ACCESS
Small quantities of oxygen counterintuitively improve the efficiency of a prospective electrochemical ammonia synthesis.
Reports
    BY
    • Tiarnan A. S. Doherty
    • Satyawan Nagane
    • Dominik J. Kubicki
    • Young-Kwang Jung
    • Duncan N. Johnstone
    • Affan N. Iqbal
    • Dengyang Guo
    • Kyle Frohna
    • Mohsen Danaie
    • Elizabeth M. Tennyson
    • Stuart Macpherson
    • Anna Abfalterer
    • Miguel Anaya
    • Yu-Hsien Chiang
    • Phillip Crout
    • Francesco Simone Ruggeri
    • Sean M. Collins
    • Clare P. Grey
    • Aron Walsh
    • Paul A. Midgley
    • Samuel D. Stranks
  • : 1598-1605
  • FULL ACCESS
Octahedral tilting stabilizes formamidinium-based photoactive perovskites and prevents the formation of local charge-trap sites.
    BY
    • Qing-Fang Lin
    • Zihao Rei Gao
    • Cong Lin
    • Siyao Zhang
    • Junfeng Chen
    • Zhiqiang Li
    • Xiaolong Liu
    • Wei Fan
    • Jian Li
    • Xiaobo Chen
    • Miguel A. Camblor
    • Fei-Jian Chen
  • : 1605-1608
  • FULL ACCESS
A thermally stable aluminosilicate with extra-large multidimensional pores and interconnecting supercages was synthesized.
    BY
    • Evgeny A. Mashkovich
    • Kirill A. Grishunin
    • Roman M. Dubrovin
    • Anatoly K. Zvezdin
    • Roman V. Pisarev
    • Alexey V. Kimel
  • : 1608-1611
  • FULL ACCESS
Terahertz light pulses were used to coherently couple antiferromagnetic spins to the lattice.
    BY
    • Qi Zhou
    • Michael Chin
    • Yue Fu
    • Peng Liu
    • Yang Yang
  • : 1612-1616
  • FULL ACCESS
P-450 enzymes are engineered to enable enantio- and diastereoselective radical cyclization reactions.
    BY
    • Dai-Ming Tang
    • Sergey V. Erohin
    • Dmitry G. Kvashnin
    • Victor A. Demin
    • Ovidiu Cretu
    • Song Jiang
    • Lili Zhang
    • Peng-Xiang Hou
    • Guohai Chen
    • Don N. Futaba
    • Yongjia Zheng
    • Rong Xiang
    • Xin Zhou
    • Feng-Chun Hsia
    • Naoyuki Kawamoto
    • Masanori Mitome
    • Yoshihiro Nemoto
    • Fumihiko Uesugi
    • Masaki Takeguchi
    • Shigeo Maruyama
    • Hui-Ming Cheng
    • Yoshio Bando
    • Chang Liu
    • Pavel B. Sorokin
    • Dmitri Golberg
  • : 1616-1620
  • FULL ACCESS
Strain and heating of carbon nanotubes in a transmission electron microscope created internal metal-semiconductor junctions.
    BY
    • Matthew McCallum
    • Alexandra C. Walls
    • Kaitlin R. Sprouse
    • John E. Bowen
    • Laura E. Rosen
    • Ha V. Dang
    • Anna De Marco
    • Nicholas Franko
    • Sasha W. Tilles
    • Jennifer Logue
    • Marcos C. Miranda
    • Margaret Ahlrichs
    • Lauren Carter
    • Gyorgy Snell
    • Matteo Samuele Pizzuto
    • Helen Y. Chu
    • Wesley C. Van Voorhis
    • Davide Corti
    • David Veesler
  • : 1621-1626
  • Open Access
Changes to the SARS-CoV-2 viral spike protein allow it to evade neutralizing antibodies but do not increase binding to the host receptor.
    BY
    • Abdullah M. Syed
    • Taha Y. Taha
    • Takako Tabata
    • Irene P. Chen
    • Alison Ciling
    • Mir M. Khalid
    • Bharath Sreekumar
    • Pei-Yi Chen
    • Jennifer M. Hayashi
    • Katarzyna M. Soczek
    • Melanie Ott
    • Jennifer A. Doudna
  • : 1626-1632
  • Open Access
SARS-CoV-2–like particles enable rapid and safe analysis of viral variants.
    BY
    • Christine N. Spencer
    • Jennifer L. McQuade
    • Vancheswaran Gopalakrishnan
    • John A. McCulloch
    • Marie Vetizou
    • Alexandria P. Cogdill
    • Md A. Wadud Khan
    • Xiaotao Zhang
    • Michael G. White
    • Christine B. Peterson
    • Matthew C. Wong
    • Golnaz Morad
    • Theresa Rodgers
    • Jonathan H. Badger
    • Beth A. Helmink
    • Miles C. Andrews
    • Richard R. Rodrigues
    • Andrey Morgun
    • Young S. Kim
    • Jason Roszik
    • Kristi L. Hoffman
    • Jiali Zheng
    • Yifan Zhou
    • Yusra B. Medik
    • Laura M. Kahn
    • Sarah Johnson
    • Courtney W. Hudgens
    • Khalida Wani
    • Pierre-Olivier Gaudreau
    • Angela L. Harris
    • Mohamed A. Jamal
    • Erez N. Baruch
    • Eva Perez-Guijarro
    • Chi-Ping Day
    • Glenn Merlino
    • Barbara Pazdrak
    • Brooke S. Lochmann
    • Robert A. Szczepaniak-Sloane
    • Reetakshi Arora
    • Jaime Anderson
    • Chrystia M. Zobniw
    • Eliza Posada
    • Elizabeth Sirmans
    • Julie Simon
    • Lauren E. Haydu
    • Elizabeth M. Burton
    • Linghua Wang
    • Minghao Dang
    • Karen Clise-Dwyer
    • Sarah Schneider
    • Thomas Chapman
    • Nana-Ama A. S. Anang
    • Sheila Duncan
    • Joseph Toker
    • Jared C. Malke
    • Isabella C. Glitza
    • Rodabe N. Amaria
    • Hussein A. Tawbi
    • Adi Diab
    • Michael K. Wong
    • Sapna P. Patel
    • Scott E. Woodman
    • Michael A. Davies
    • Merrick I. Ross
    • Jeffrey E. Gershenwald
    • Jeffrey E. Lee
    • Patrick Hwu
    • Vanessa Jensen
    • Yardena Samuels
    • Ravid Straussman
    • Nadim J. Ajami
    • Kelly C. Nelson
    • Luigi Nezi
    • Joseph F. Petrosino
    • P. Andrew Futreal
    • Alexander J. Lazar
    • Jianhua Hu
    • Robert R. Jenq
    • Michael T. Tetzlaff
    • Yan Yan
    • Wendy S. Garrett
    • Curtis Huttenhower
    • Padmanee Sharma
    • Stephanie S. Watowich
    • James P. Allison
    • Lorenzo Cohen
    • Giorgio Trinchieri
    • Carrie R. Daniel
    • Jennifer A. Wargo
  • : 1632-1640
  • FULL ACCESS
Higher dietary fiber intake and avoiding probiotics improves immunotherapy responses in melanoma patients and mouse models.

Careers

Working Life
    BY
    • Jennifer Lanni
  • : 1642-1642
  • FULL ACCESS

Association Affairs

    BY
    • Earl Lane
    • Emily Hughes
  • : 1570-1571
  • FULL ACCESS
Reports from the ongoing pandemic highlighted the entries

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