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Current Issue of SCIENCE


Contents | Science 375, 6576
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COVER Lipid nanoparticles (spheres) use antibodies against the CD5 protein (antibodies, blue; CD5, red) to specifically target T cells while inside the bloodstream and tissues. The nanoparticles deliver mRNA to T cells, reprogramming them in vivo to transiently express chimeric antigen receptors (gold) that target pathogenic cardiac fibroblasts. In vivo–engineered T cells mitigate cardiac fibrosis and improve heart function in a mouse model. See pages 23 and 91.

Illustration: C. Bickel/Science

Science

  • Volume 375|
  • Issue 6576|
  • 7 Jan 2022

COVER Lipid nanoparticles (spheres) use antibodies against the CD5 protein (antibodies, blue; CD5, red) to specifically target T cells while inside the bloodstream and tissues. The nanoparticles deliver mRNA to T cells, reprogramming them in vivo to transiently express chimeric antigen receptors (gold) that target pathogenic cardiac fibroblasts. In vivo–engineered T cells mitigate cardiac fibrosis and improve heart function in a mouse model. See pages 23 and 91.

Illustration: C. Bickel/Science

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