I would like to invite you to *ESEB 2025*, which will take place in *Barcelona from 17 to 22 August 2025*. The registration and abstract submission have been opened and the interest is already high, with many colleagues already registering at a fast pace, actively submitting abstracts, and reaching out for information. With *51 symposia*, excellent keynote and invited speakers, and an outstanding programme, we hope to bring together most of our scientific community. After three years since the last ESEB congress in Prague, this is a long-awaited opportunity to reconnect. In addition to the scientific sessions, we are* preparing engaging activities* to make the most of the city's culture and atmosphere. It will be a great opportunity to exchange ideas, meet colleagues and enjoy a stimulating week. The *congress venue, CCIB*, is a modern space facing the sea, providing a fantastic setting for discussions and networking. To make the most of this unique location, we are organising a welcome cocktail on a beautiful terrace overlooking the Mediterranean and a memorable closing dinner at the Museu Marítim of Barcelona, a venue full of history and character. We also suggest considering *extending your stay to enjoy Barcelona* before or after the congress, whether on your own or with family and friends. With its stunning beaches, excellent cuisine, lively cultural scene, and easy access to other parts of Catalonia, it is an ideal place for a short holiday. If you have not yet registered, we encourage you to do so soon* and benefit from a reduced early-bird registration fee*. We look forward to welcoming as many of you as possible to make this an exceptional event. For full details and registration, please visit: https://eseb2025.com/ We look forward to seeing you in Barcelona. Best regards, *Toni Gabaldón* Chair, ESEB 2025 Organising Committee Toni Gabaldón (to subscribe/unsubscribe the EvolDir send mail to golding@mcmaster.ca)