Dear EvolDir colleagues, We would like to briefly share the publication of a new Quest for Orthologs special issue in the Journal of Molecular Evolution: https://link.springer.com/collections/hcifbfjbhe The issue comprises 12 articles covering recent methodological, conceptual, and applied developments in orthology, including topics such as functional divergence, hierarchical orthologous groups, protein domains and synteny, AI-based approaches, and community tools and resources. The collection was inspired by discussions in the broader orthology community and may be of interest to researchers working in evolutionary biology, comparative genomics, and functional annotation. We hope you will take a look and that you will enjoy the content. With best wishes, Natasha Glover and David Liberles Natasha Glover (to subscribe/unsubscribe the EvolDir send mail to golding@mcmaster.ca)