Working for the Department of Biology you will be responsible for carrying out research for a Gordon & Betty Moore Foundation grant with aim of understanding the pathways that control a nascent endosymbiotic interaction between a protist and green algae. The project will involve single cell transcriptome, hyper-LOPIT 3D subcellular proteomics data combined with RNAi approaches to identify how a host cell can manipulate the fate of its endosymbiotic partner cells. Using these datasets, we will then apply phylogenomic methods to understand how host control mechanisms evolve in endosymbiotic interactions. You will have the opportunity to use a number of established datasets and so must be confident in a range of bioinformatic approaches. As such the post could be largely a bioinformatic post or one that combines an equal share of bioinformatic analyses and laboratory work. More information about the job can be found here: https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form More information about the research group can be found here: https://protists.co.uk Thomas Richards ----- You will join the Richards molecular microbiology group with responsibility for carrying out research for a Leverhulme Trust project with aim of characterising the structural biology of unique fungal organelles associated with rhodopsin function and phototaxis (a putative subcellular eye). The project will focus on using cutting edge structural microscopy (FIB-SEM and CryoET) to characterise prominent uniform structures found in these organelles (working between the departments of Biology and Biochemistry). You must be capable of working independently and will be responsible for developing new protocols for isolation of sub cellular fractions and performing CryoET, FIB-SEM, subtomogram analysis and model building. The successful candidate must also take these data through to protein structural bioinformatic analyses. More information about the job can be found here: https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form More information about the research group can be found here: https://protists.co.uk Thomas Richards Thomas Richards (to subscribe/unsubscribe the EvolDir send mail to golding@mcmaster.ca)